Ascorbate is its ionised (deprotonated) form, which predominates in the body at physiological pH. Ascorbate is the focus of new Vitamin C research #ccrdownunder

The preparation is important- Mark Plummer nicely outlining the importance of understanding what is studied in Vit C trials
Ascorbic acid is the acidic, protonated form of Vit C (used in many trials and may explain the harm 1/2 #ccrdownunder #VITACCtrial

Hi Jack :)

Next up VITaCC results session (Early high-dose vitamin C in post-cardiac arrest syndrome) up next at #CCRdownunder #VITACCtrial

Congratulations to the RSI trial team #CCRdownunder

Next up RSI results session (Etomidate vs Ketamine for intubation) up next at #CCRdownunder #RSItrial

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting #### Summary points

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

Respiratory support with standard low-flow oxygen therapy, high-flow oxygen therapy or continuous positive airway pressure in adults with acute hypoxaemic respiratory failure in a resource-limited setting: protocol for a randomised, open-label, clinical trial – the Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) study Acute hypoxaemic respiratory failure (AHRF) is associated with high mortality in sub-Saharan Africa. This is at least in part due to critical care-related resource constraints including limited access to invasive mechanical ventilation and/or highly ...

And here is the protocol publication for #ARISEAFRICAtrial: pmc.ncbi.nlm.nih.gov/articles/PMC... #ccrdownunder

Not as yet but hopefully soon!

First up on Day 2 of #CCRdownunder is #ARISEAFRICAtrial. Post your questions using the hash tags and follow the live stream here: criticalcarereviews.com
@criticalcarereviews.com

JAMA Research Summary: Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults. Closed-loop ventilation: 16.7 days. Conventional ventilation: 16.3 days.

Research Summary: Early use of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation. #CCRdownunder ja.ma/48AgJCj

Last session of the day- ACTiVE Trial #ACTIVEtrial #ccrdownunder

JAMA article titled 'Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding'. Key points: cryopreserved platelets may be less effective/safe than liquid-stored for cardiac surgery bleeding; didn't meet noninferiority criterion.

Among adults undergoing cardiac surgery at high risk of bleeding and platelet transfusion, cryopreserved platelets did not meet noninferiority for controlling postoperative bleeding and were less effective than liquid-stored platelets. #CCRdownunder ja.ma/4rEC06z

Next up #ccrdownunder - #CLIPIItrial
Post your questions at #ccrdownunder and #CLIPIItrial or at the livestream: criticalcarereviews.com @criticalcarereviews.com

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-blind clinical and cost-effectiveness trial The consequences of critical illness can be substantial and multifactorial, encompassing physical deconditioning, mental health impairments, fatigue, and declines in health-related quality of life. We hypothesise that for people discharged after ...

A wonderful example of extensive PPIE in a trial, including trying to address aspects of diversity and ensure wide engagement in a complex intervention- look forward to the primary results publication

pmc.ncbi.nlm.nih.gov/articles/PMC...

#irehabtrial #CCRDownUnder

Second at #ccrdownunder - #IREHABtrial
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com

ImmunoSep uses a double-dummy design.
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder

JAMA graph titled 'Figure 2. Primary End Point'. 'Change from the baseline SOFA score' is plotted for precision immunotherapy (orange) and placebo (blue). SOFA scores range from 0 to 20; x-axis is 1 to 145.

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

Up first at #ccrdownunder - #IMMUNOSEPtrial
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com

Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!

Very proud to be here as part of the TARGET PROTEIN study team and support Lee-anne Chapple, Matt Summers and Adam Deane (with Sandy Peake)

#CCR25

jamanetwork.com/journals/jam...

Always a good conference to follow for innovative trial designs in the context of critical care 👇🏻 #CCR25

Congratulations to all the sites of TARGET PROTEIN, the ANZICS CTG and all members of the management committee

#CCR25

🍎 Our international practice varies so much- this is why initiatives such as #FRANC24 are so important. More to come- we are not finished yet!!!

🍎 Prof Mette Berger, international expert in ICU metabolism and nutrition, reminds us to GO BACK TO PHYSIOLOGY- don't discount early physiology studies.
🍎Have you read the 1981 WHO report on energy and protein requirements that summarises metabolism? iris.who.int/bitstream/ha...

Dynamic assessment of prealbumin for nutrition support effectiveness in critically ill patients Serum prealbumin is considered to be a sensitive predictor of clinical outcomes and a quality marker for nutrition support. However, its susceptibility to inflammation restricts its usage in criticall...

Prehab principles from oncology/surgery could be applied in the post ICU period??
🍎 An interesting study by Emmanuel Prado which may serve as an indication of ability to feed patients: clinicalnutritionjournal.com/article/S026...

Thank you to Fresenius Kabi for a fabulous #FRANCASIA25 in beautiful Taiwan. It was my privilege to be part of the speaking team and share knowledge.

The combined program of ICU, oncology and surgery provides the opportunity to learn from each field

Some key takeaways 1/

Dynamic assessment of prealbumin for nutrition support effectiveness in critically ill patients Serum prealbumin is considered to be a sensitive predictor of clinical outcomes and a quality marker for nutrition support. However, its susceptibility to inflammation restricts its usage in criticall...

🍎 Prehab principles from oncology/surgery could be applied in the post ICU period??
🍎 An interesting study by Emmanuel Prado which may serve as an indication of ability to feed patients: clinicalnutritionjournal.com/article/S026...

Critical care, climate health and stronger health services to be the focus of Investigator Grant successes Improvements to acute and critical care medicine, tackling the health impacts of climate change, and driving more equitable, sustainable health services will be a major focus for researchers in our Sc...

I am thrilled to receive an #NHMRC EL2 fellowship. I aim to use novel trial design to investigate nutrition interventions in critical illness. I also wish to acknowledge the many deserving applicants who missed out @monashuniversity.bsky.social

www.monash.edu/medicine/new...

Hi all!! I have recently come across from X (@ICUnutrition)- I am an A/Prof and Critical Care Dietitian- you can see more about my work here:
www.monash.edu/medicine/sph...

Follow along if you want to receive my updates!