Read in Nature: nature.com/articles/s41586-025-09899-8

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8

Excited to share our new publication introducing NoLMseq, a method based on laser microdissection of individual nucleoli that enables single-cell mapping of genome-nucleolus interactions across development and under cellular stress.

www.nature.com/articles/s41...

Finally out! We introduce NoLMseq, a #nucleolus laser microdissection method to capture single-cell genome-nucleolus interactions in normal and stressed nucleoli, revealing novel insights into genome organization & function. www.nature.com/articles/s41...

Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26!

Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico.

Speakers, details & registration➡️ bit.ly/46JQbze

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states Online now:

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

Predicting gene expression from DNA sequence using deep learning models Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....

Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

The EMBL conference '#Chromatin & #Epigenetics' opens today!
Organized by
🌟Asifa Akhtar @mpi-ie.bsky.social
🌟Amanda Fisher @ox.ac.uk
🌟Bing Ren @ucsandiego.bsky.social
🌟Dirk Schübeler @fmiscience.bsky.social

Looking forward to an exciting meeting!

@events.embl.org #EMBLChromatin

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

Very excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social
www.biorxiv.org/content/10.1...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates Without surveillance, errors in ribosome assembly can lead to the buildup of defective intermediates that impair protein production. Akers et al. developed a system to model faulty ribosomes in human cells and discovered that the protein ZNF574 targets these intermediates for degradation. Loss of quality control results in defective ribosome buildup that jeopardizes cellular homeostasis and organismal health.

Online Now: ZNF574 is a quality control factor for defective ribosome biogenesis intermediates Online now:

Exciting PhD project available in our lab (time sensitive)! 👇