BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Thanks also to YIsrael Rappaport who started this project, and Hanna Achache ,who pulled us out of the bog.
Also, a huge shoutout to the editor and staff of
@natcomms.nature.com, who were patient, helpful, and accessible. The most amazing professionals I had the good fortune to work with.
How do they do it? We are finding out…
This work has been almost completely done by the amazing student Roni Falk. I am sorry to see her leave for a postdoc, but I know it is she could become an independent scientist who will contribute a lot to the field of #Fertility.
In line with the role of lncRNA in promoting meiosis, their level increases as the cells move towards meiosis, and the number of FBF-2 condensates decreases. Thus, the lncRNAs promote meiosis by binding FBF-2 and deactivating it by promoting its condensation.
Indeed, in the triple lncRNA mutant, transcripts that are repressed by FBF-2 were over-repressed. At least one of the lncRNAs colocalizes with FBF-2 in peri-nuclear condensates and P granules. Deletion of the lncRNAs reduced FBF-2 condensates, and it stayed in the cytoplasm.
We deleted the genes encoding these three lncRNAs and identified a severe reduction of proliferating germ cells and progeny. This phenotype is similar to overexpression of FBF-2, suggesting that the lncRNAs repress FBF-2.
LncRNAs are highly expressed in the gonads, but KO of single genes usually results in no obvious phenotype. 3 lncRNAs bind the protein FBF-2 that tilts the balance of germ cells towards stem cell proliferation, and delays meiosis.
So excited about our recent 📜in @natcomms.nature.com
In short, we found 3 lncRNAs that ensure oocyte differentiation by condensing FBF-2, a protein that prevents meiosis entry. And yes, a homologous mechanism probably exists in mammals.
#fertility #lncRNA #meiosis
nature.com/articles/s41...
One of the best collaborations we ever had.
Brainstorming with @ethanewe.bsky.social whenever a new result came up, was so uplifting and we felt like we boldly go where no one has gone before.
Top tier research institutions: grab him while you can!
WOoo! Hot pre-print alert! 🔥 Check out our new story - We describe evidence that "neuronal oversight" of germline small RNAs prevents sterility and allows lab-domesticated C. elegans to reproduce when temperatures go up (1/2)
www.biorxiv.org/content/10.1...
So proud we could take part in this amazing project!
Germline/meiosis crowd, you must check this out. A whole new dimension of non-cell autonomous control on gametogenesis.
Also, triple shoutout for @ethanewe.bsky.social . A great PI on the way
#meiosis #germline #ncRNA
After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...
We go to so many meetings and conferences that most just blend into our memory.
But rare ones stand out and truly change the way we think and do science.
👇This was one of those that will stay a part of me.
A kind invitation by the Cell Biology Department of @charlesuni.cuni.cz brought Israeli scientist stranded in Prague after the #TCTeAC to do what we love best - participate in exciting scientific discussions!
@barakrotblat.bsky.social : "close you eyes and think about being alive". Me: "is it worth living in glucose starvation?" #TCTeAC
@tzurlab.bsky.social Yonathan Tzur at Woodstock Night Science conference #TCTEAC
Balance as a key in life and our biological question. Yonatan Tzur #TCTeAC
And now Ahmed Elewa with a beautiful development biology talk
And here it starts:
@woodstocknightsci.bsky.social
#TCTeAC
#theconferencetoendallconferences
Another great example of the pivotal role of MAPK in reproduction
With @gazitroi.bsky.social on our way to
#theconferencetoendallconferences
In this conference we couldn't care less where you published your story because 1. we only care if it's interesting and good and 2. participants will discuss unpublished work
With more research in this direction the former may not be so certain!
GIF where you're from
🔊
We are recruiting PhD students and Postdocs!
We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.
1/5
The deadline to apply to our Ph.D. program is two weeks away. Apply by December 1st!
💕 6 tools for illustrating your scientific works! (FREE)
👉Read my Article on Medium here: medium.com/@vespinozag/...
#genomic #chemistry #Academic #DataVisualization #postdoc #MachineLearning #DataScience #Bioinformatics #PhD #health #Python #Statistics #Programing #neuroscience #biology #science
People of Bluesky, let’s get to know each other better: What is one of your favorite movies?
Quote share your answer in a gif! 🎥
@tzurlab.bsky.social
