I have something I’d like to trade in for that

Getting there.. #everydayimwaffling

Ready for some heavy lifting 🪡

It’s one of the reasons why I’m terrified of putting an out of office message

3dem madness 😅

Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism.

Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk

Every day I’m wafflin’ 🎶

Carboxylases are the best 🥰

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

What is the weight of an EM grid? 🤔

High-pressure freezer. Vitrifies samples that are too thick for standard plunge-freezing 👌

New toy installed 💥🧊

Amazing, I wonder how many people are now sprinting back to some of their old data sets of small particles that they could never successfully process.. err, i have to go 🏃‍♂️💨

Yes great, new grid boxes that have no space to write on. With lids that no standard tool can open. 👍

Checked with Thermo, the plan 4 does take standard cassettes from standard nanocabs. The only thing that is (obviously) not compatible is the optional vacuum nanocab and the plan 3 autoloader (but it can be upgraded). The tomogrids are compatible with both autoloaders

“Existing instruments
equipped with an Autoloader can be retrofitted to be
compatible with both standard capsules and the
Vacuum Capsule.” This implies a system can take both types of capsules

Yeah that’s if you want to use the new vacuum nanocab on the older systems.. but what about using the normal nanocab on the new autoloader?

Unless i misunderstand this somewhat hazy documentation, which is entirely possible 😅

I don’t think the plan 3 and plan 4 autoloaders are per se not compatible.. the plan 4 does still take the normal cassettes, right? You’re only referring to the new TomoGrids for which you need the plan 4

Fair enough, but I normally have other plans in the night 🤔💤

Received program for amazing cryo-EM symposium 👍 It’s on a Saturday, 9-5 🤦🏻‍♂️

Dinner for One - The Original YouTube video by Photography and Me

Indulged in the popular German New Years Eve tradition of watching Dinner for One - you may wish to indulge, or not

youtu.be/2pbJlHMpUlU?...

Exciting! Can you let us know here 🦋 how install and benchmarking is going?

Woohoo congrats!

No raw micrograph or processing figure?? Could you please add this during peer review ?@micharapelab.bsky.social

My UBR4, despite being very active, always looked like garbage on the grids. Need to dig in here to find the secret sauce! Congrats to @micharapelab.bsky.social lab et al

Nice 🥳

Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1 Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 lig...

New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky.
www.biorxiv.org/content/10.1...

A Brave New World

When are there too many starter packs? 🤔