Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain.

Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain. www.nytimes.com/2026/04/04/b...

CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology!
#lipidbiology #cellbiology #biorxiv #sphingolipids

Why it matters 🧠
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?

Our work uncovers a new molecular player: CNPY4.

CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.

CNPY4 is a Lipid-Binding Regulator of Sphingolipid Homeostasis Sphingolipids function both as signaling molecules and as organizers of cell membranes, and their dysregulation has been linked to cancer, metabolic disorders, and neurodegeneration. A central node in...

Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1

Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.

3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference | Fusion Conferences Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

🔔SAVE THE DATE!🔔

Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.

More info➡️ bit.ly/474De1E

New Cedars-Sinai Study Aims to Improve Oral Tissue Grafts A new study at Cedars-Sinai Guerin Children’s, funded by a $5.7 million NIH grant, is exploring the use of stem cells to enhance oral tissue grafting.

www.cedars-sinai.org/newsroom/ced...

YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago!

It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.

Visit FundResearch.org to tell Congress to keep funding research

#SaveOurCures #PhoneForGood #FundNIH

🎉 INTRODUCING #SaveOurCures🎉

Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.

93% of cancer treatments started with American government-funded research.
🧵:

1/8

Trump Is Shutting Down the War On Cancer

Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...

Opinion | We Are Watching a Scientific Superpower Destroy Itself

www.nytimes.com/2025/09/08/o...

Director, Reproductive Sciences Program at CEDARS-SINAI Learn more about applying for Director, Reproductive Sciences Program at CEDARS-SINAI

We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...

🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...

The Great Unbalding Draws Nearer Decades of science have not found a way to regrow lost hair. Until, maybe, now.

UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪

Preclinical Study Unlocks a Mystery of Rapid Mouth Healing Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ...

The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body."
www.cedars-sinai.org/newsroom/pre...

Preclinical Study Unlocks a Mystery of Rapid Mouth Healing Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ...

"Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A new study has discovered one secret of this disappearing act.

Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa.

Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:

Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea...
Looking forward to seeing you there!

Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa
www.science.org/doi/10.1126/...
@ophirklein.bsky.social

Here Is All the Science at Risk in Trump’s Clash With Harvard More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.

Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...

Help Save the NIH As the second largest recipient of NIH funding in the nation, UCSF depends on NIH funding to support our researchers in advancing health worldwide. Unfortunately, the White House's budget request pr...

Help Save the NIH www.congressweb.com/UCSF/9?frame...

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.

“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”

Read the article here. No subscription required:

www.nytimes.com/2025/06/03/u...

Sorry to read this and glad you are on the mend!

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

www.nytimes.com/2025/06/03/u...

Opinion | In the Future, China Will Be Dominant. The U.S. Will Be Irrelevant.

www.nytimes.com/2025/05/19/o...

Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

→ europa.eu/!TTbWbJ

Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF Earlier today on May 2, the Trump Administration proposed sweeping cuts across the U.S. Department of Health and Human Services (HHS), including a nearly 40% cut to the National Institutes of Health (...

Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF www.congressweb.com/ASHG/32?fram...

Opinion | What Is Actually the Point of Treating the N.I.H. Like This? Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why?

This is something I keep asking myself: www.nytimes.com/2025/04/11/o...

It was an honor to speak at the Shanthi Sitaraman Symposium at Emory yesterday, and to hear about Shanthi from her colleagues, friends and family. She was a remarkable physician, scientist and teacher.