Join us on April 15, 2026 (online, 10:00–11:30) for an exciting talk by:
Prof L. Ashley Cowart (Virginia Commonwealth University & Richmond Veterans' Affairs Medical Center).
Topic: Sphingolipids in health and disease
Register: ucdavis.zoom.us/meeting/regi... #Sphingolipids #Metabolomics #Research
Synergistic role of GhGCS1 in cotton root development and verticillium wilt resistance
Qiaoling Wang, Xingying Yan ... Ming Luo, Fan Xu
link.springer.com/article/10.1...
#Cotton #Sphingolipids #RootDev #PlantImmunity
Sphingolipids Market Projection: Growth to $1,145.6 Million by 2035 #None #Ceramides #Sphingolipids #Liposome_Drug_Delivery
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology!
#lipidbiology #cellbiology #biorxiv #sphingolipids
Grand Rounds presentation by Dr. Ben Lidgard, "Friend or Foe? #Sphingolipids in Patients Treated with #Hemodialysis."
#dialysis #nephsky @uwmedicine.bsky.social
youtu.be/Zafp8H8ntUw
RICTOR-UGCG Axis: A Molecular Control Panel for Cancer Proliferation. This cartoon visually metaphorizes the intricate molecular mechanisms driving cancer cell proliferation, specifically highlighting a critical fault in metabolic circuitry. The artwork depicts the RICTOR–UGCG signaling axis as a sophisticated control panel, analogous to an electrical switchboard where UGCG is transcriptionally regulated by the transcription factor ZFX. At the heart of this "circuitry" is RICTOR (Rapamycin-Insensitive Companion of mTOR), presented as a master switch, which when activated (switched "ON"), initiates a cascade of signals leading to the deregulation of key epigenetic regulators, DNMT1 and KDM5A. This epigenetic dysregulation, represented by the complex wiring above the RICTOR switch, subsequently enhances the activity of UGCG (UDP-glucose ceramide glucosyltransferase). The heightened UGCG activity results in a significant imbalance in the levels of GD3 and GM1 gangliosides, specifically leading to elevated GD3 levels, which is visually represented on the bioincubator. The elevated GD3 levels activate EGFR (Epidermal Growth Factor Receptor) signaling. EGFR dimerization becomes the driver of uncontrolled cell proliferation, symbolized by the rapidly multiplying cancer cells within the bioincubator glass dome. This interconnected circuitry metaphor illustrates how mTORC2-driven lipid rewiring (via RICTOR and ganglioside metabolism) and epigenetic regulation converge synergistically to promote and sustain tumor progression. Image Credit: Animesh Kar & Mohammad Nafees Ansari (using Procreate).
We know that the mTORC2 complex regulates lipid synthesis in #cancer, but how? This study shows that RICTOR (reg subunit of mTORC2) regulates synthesis of #sphingolipids & #gangliosides by modulating expression of the UGCG enzyme, so promoting #BreastCancer growth @plosbiology.org 🧪 plos.io/42q1Hg4
RICTOR-UGCG Axis: A Molecular Control Panel for Cancer Proliferation. This cartoon visually metaphorizes the intricate molecular mechanisms driving cancer cell proliferation, specifically highlighting a critical fault in metabolic circuitry. The artwork depicts the RICTOR–UGCG signaling axis as a sophisticated control panel, analogous to an electrical switchboard where UGCG is transcriptionally regulated by the transcription factor ZFX. At the heart of this "circuitry" is RICTOR (Rapamycin-Insensitive Companion of mTOR), presented as a master switch, which when activated (switched "ON"), initiates a cascade of signals leading to the deregulation of key epigenetic regulators, DNMT1 and KDM5A. This epigenetic dysregulation, represented by the complex wiring above the RICTOR switch, subsequently enhances the activity of UGCG (UDP-glucose ceramide glucosyltransferase). The heightened UGCG activity results in a significant imbalance in the levels of GD3 and GM1 gangliosides, specifically leading to elevated GD3 levels, which is visually represented on the bioincubator. The elevated GD3 levels activate EGFR (Epidermal Growth Factor Receptor) signaling. EGFR dimerization becomes the driver of uncontrolled cell proliferation, symbolized by the rapidly multiplying cancer cells within the bioincubator glass dome. This interconnected circuitry metaphor illustrates how mTORC2-driven lipid rewiring (via RICTOR and ganglioside metabolism) and epigenetic regulation converge synergistically to promote and sustain tumor progression. Image Credit: Animesh Kar & Mohammad Nafees Ansari (using Procreate).
We know that the mTORC2 complex regulates lipid synthesis in #cancer, but how? This study shows that RICTOR (reg subunit of mTORC2) regulates synthesis of #sphingolipids & #gangliosides by modulating expression of the UGCG enzyme, so promoting #BreastCancer growth @plosbiology.org 🧪 plos.io/42q1Hg4
RICTOR-UGCG Axis: A Molecular Control Panel for Cancer Proliferation. This cartoon visually metaphorizes the intricate molecular mechanisms driving cancer cell proliferation, specifically highlighting a critical fault in metabolic circuitry. The artwork depicts the RICTOR–UGCG signaling axis as a sophisticated control panel, analogous to an electrical switchboard where UGCG is transcriptionally regulated by the transcription factor ZFX. At the heart of this "circuitry" is RICTOR (Rapamycin-Insensitive Companion of mTOR), presented as a master switch, which when activated (switched "ON"), initiates a cascade of signals leading to the deregulation of key epigenetic regulators, DNMT1 and KDM5A. This epigenetic dysregulation, represented by the complex wiring above the RICTOR switch, subsequently enhances the activity of UGCG (UDP-glucose ceramide glucosyltransferase). The heightened UGCG activity results in a significant imbalance in the levels of GD3 and GM1 gangliosides, specifically leading to elevated GD3 levels, which is visually represented on the bioincubator. The elevated GD3 levels activate EGFR (Epidermal Growth Factor Receptor) signaling. EGFR dimerization becomes the driver of uncontrolled cell proliferation, symbolized by the rapidly multiplying cancer cells within the bioincubator glass dome. This interconnected circuitry metaphor illustrates how mTORC2-driven lipid rewiring (via RICTOR and ganglioside metabolism) and epigenetic regulation converge synergistically to promote and sustain tumor progression. Image Credit: Animesh Kar & Mohammad Nafees Ansari (using Procreate).
We know that the mTORC2 complex regulates lipid synthesis in #cancer, but how? This study shows that RICTOR (reg subunit of mTORC2) regulates synthesis of #sphingolipids & #gangliosides by modulating expression of the UGCG enzyme, so promoting #BreastCancer growth @plosbiology.org 🧪 plos.io/42q1Hg4
Intestinal #bacterium allows #microbiome-mediated protection against #pathogens ...
| #microbes | #bacteria | #Caenorhabditis | #nematode | #Pseudomonas | #sphingolipids | Via @sciencex.bsky.social
Los esfingolípidos son unos lípidos de membrana muy especiales y con funciones indispensables para la reproducción masculina. Si quieres saber más, un revisión actualizada:
link.springer.com/article/10.1...
#bianorbiotech #MaleReproduction #Sphingolipids #spermatogenesis #fertility
The enzyme SMPDL3b in podocytes decouples proteinuria from #chronickidneydisease progression in experimental #Alport Syndrome
doi.org/10.1016/j.kint.2025.04.024
#MedSky #NephSky #OpenAccess #CKD #glomerulardisease #sphingolipids #podocyte
Particle Metrix booth with the ZetaView Evolution at FEBS2025 Special Meeting.
Good morning from @febsopenbio.bsky.social x @slbiology.bsky.social in Varna 🇧🇬!
Bertrand DAMART presents the new ZetaView® Evolution + f-NTA EV Kits.
🗓 May 26 | 🕙 10:20 | 📍“Your EV Solution”
Visit the @particle-metrix.bsky.social booth!
#EVs #NTA #nanoparticles #Sphingolipids #ZetaViewEvolution
We're excited to join the 2025 @febsopenbio.bsky.social Meeting on @slbiology.bsky.social & the 13th Ceramide Conference!
🔬 Visit us at the @particle-metrix.bsky.social booth!
🎤 Don’t miss Bertrand Damart’s talk!
#FEBS2025 #Sphingolipids #Ceramide #LifeScience #ParticleMetrix #NTA #ZetaViewEvolution
Can bacteria help design better drug delivery systems? Joshua Chamberlain shows how a novel lipid from Caulobacter may unlock new potential for lipid nanoparticles in vaccines and therapies. Learn more here: wix.to/80ZubKQ #Microbiology #DrugDelivery #LipidNanoparticles #Sphingolipids #Rutgers
Development of an iPSC-derived immunocompetent skin model for identification of skin sensitizing substances - May 6, 2025
@journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#stemcells #immunology #tissueengineering #sphingolipids #openaccess
Using #massspecimaging we show #lipid #metabolism is dysregulated spatially in #liverfibrosis. By integrating MSI and IMC, we linked #sphingolipids with non-parenchymal cells. Targeting sphingolipid metabolic pathway in HSCs and hPCLSs showed anti-fibrotic effect.
At least I'm finishing this year on a high!
Feel free to reach out to me directly if you would like to know more about this and other PhD research opportunities in our group.
#LipidSky #metabolomics #lipidomics #obesity #sphingolipids #ceramides
#Cholesterol may #Not be the #Only #Lipid involved in #Trans #Fat-driven #Cardiovascular #Disease
New research from Salk Institute describes another class of lipids, #sphingolipids, contributes to arterial plaques & atherosclerotic cardiovascular disease scitechupdates.com/cholesterol-...
Very happy to share our recent publication with you.
We show that glycosylation of one of the main ceramide syntheses (CerS6) is required for its activity.
#Lipidtime #Ceramide #Sphingolipids
www.jlr.org/article/S002...
#sphingolipids I am very pleased about this wonderful piece work which was a joint effort with the Roessner group. Please enjoy reading:
link.springer.com/article/10.1...
