Check out this super cool #lipidtime imaging story from @nadlerlab.bsky.social!!

The team is ready to departure to Freiburg meeting @sfb1381.bsky.social and the spirit is top 🤩 Followed by Mosbach colloquium @gbmev.bsky.social #lipidtime, and even more membranes at icmr.hhu.de symposium @hhu.de Busy days, and so many great people to meet!

Whoa, thank you for doing this for the #lipidtime community and beyond! 🙏

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

Interesting talk by Jürgen Seibel at #Biochemistry2026. He talked about "Enzyme and Substrate Engineering for novel CAZymes activities".

#Biochemistry #ChemSky #ChemBio #Glycotime #Lipidtime

Thank you so much for this perspective, Elise...it's exciting to see lipids getting a little time in the spotlight!! 🤩 #lipidtime @elisecutts.bsky.social

#lipidtime

This is a nice one! #lipidtime

Thank you to @ibudin.bsky.social for highlighting our recent membrane editing–proximity labeling #lipidtime story with a News & Views in @natchembio.nature.com!

We hope this will be useful to anyone looking to identify ligands (substrates and inhibitors) of #lipid transporters. Thanks to @jeremybaskin.bsky.social for the invitation to write this! #lipidtime (2/2)

Master Projects DANGELOLAB

We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime
www.epfl.ch/labs/dangelo...

#lipidtime !

I want to highlight a new #lipidtime article from our lab on disease-associated 1-deoxysphingolipids, which is nicely featured on the cover of this month's issue of Cell Chem Bio @cp-cellchembiol.bsky.social www.cell.com/cell-chemica...

Graphical abstract showing prewetting at membranes

Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime

www.nature.com/articles/s41...

Membrane asymmetry as promising anti fungal target!! Cool!!
#lipidtime

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

The cell biologist’s guide to detecting and modulating membrane phospholipids | Journal of Cell Biology | Rockefeller University Press Worcester et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study lipids.

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime:

rupress.org/jcb/article/...

Dynamic network regulating phosphatidic acid homeostasis revealed using membrane editing coupled to proximity labeling Cellular lipid metabolism is subject to strong homeostatic regulation, but players involved in and mechanisms underlying these pathways remain mostly uncharacterized. Here, we develop and exploit a “F...

Stay tuned for a #lipidtime consequence of this finding from our lab, for mapping how membrane proteomes change when targeted edits are made to their lipidomes — final version coming out in Nat Chem Biol a week from tomorrow and preprint available here: www.biorxiv.org/content/10.1...)

Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).

📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026

Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime

Great #lipidtime methods article from Dazhi and Justin from the Reinisch lab on in vitro methods for reconstituting lipid scrambling and transfer!

Great talk by Floor Stevens from the group of @mvdstelt.bsky.social of our @led3hub.bsky.social at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry - Nature Communications Mixtures of peptides and nucleic acids tend to demix and form coacervate droplets. Here, the authors show that even short peptides and oligonucleotides form droplets. DNA and RNA impart different prop...

She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. (2/2) www.nature.com/articles/s41...

#ChemSky #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

Really great work, James!! Wonderful dose of #lipidtime!

An Integrative View on Multiple “Lipid Divide” Events as Hallmarks of Distinct Evolutionary Transitions Lipids are fundamental to life, serving not only as membrane components but also as key players in signaling, energy storage, and cellular identity. While the well-known “lipid divide” between Bacteri...

Do #lipids carry the signatures of #evolution?🤔

In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea

feedback/critiques all welcome 🙌 #lipidtime

pubs.acs.org/doi/10.1021/...

Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.

#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime

That is a seriously cool story. The last couple of years are have been epic for #lipidtime.

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A link...

amazing #lipidtime story from Tontonoz lab! Lipid scrambling and cholesterol accessibility IN T-CELLS regulates nutrient uptake in small intestine 🤯🤯

Physiology is so weird!
www.science.org/doi/10.1126/...

This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today

Lipid Landscape of human cells Eukaryotic cells synthesise thousands of lipid species, yet the principles that organise them across compartments remain unclear. Here we introduce PAP-SL, parallel (immuno)affinity purification coupl...

#lipidtime alert!
This preprint by Kenji Maeda (cannot find him here) & colleagues is mandatory reading by everybody with even a cursory interest in lipid biology:
www.biorxiv.org/content/10.1...

A landmark and postcard moment indeed for the #lipidtime and #chembio communities!!