My main PhD paper is finally out! ๐
After ~5 years, itโs published today in ๐๐ข๐ต๐ถ๐ณ๐ฆ ๐๐ฎ๐ฎ๐ถ๐ฏ๐ฐ๐ญ๐ฐ๐จ๐บ.
@natimmunol.nature.com
It all started with an unexpected observation ๐:
๐ Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier โฉ and more frequently ๐ than wild-type mice.
1/11 ๐งต
๐งช thanks for sharing! here's the paper without paywall if anyone's interested: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
๐งช the landscape of cell death is online! Spent half a year in Seattle, WA in @drewoberst.bsky.social `s lab, where we came up with a new way to conceptualize cell death commitment, similar to Waddington's famous landscape of lineage commitment! Thanks TJ and Andrew! #celldeath (free access๐)
WHERE ARE ALL THE DARK PROTEINS? There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway. They can be upstream or downstream of a conventional gene, or they can overlap with it to varying degrees. Many are found within long non-coding RNAs, which weren't thought to encode proteins. Some of these peptides seem to regulate the activity of nearby genes, but for most, their purpose is unclear.
#Medsky๐งช#microsky #immunosky Finding the โdark proteinsโ .There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway.
โThis year, in our #CellDeath focus:
Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis
๐https://rdcu.be/d46gt
www.nature.com/articles/s41...
hello fellow whovian
agarose gel with a happy face
sadistic smile only to mock me before I found out the PCR didn't work ๐.. #scienceisfun