The paper describing our sensitive poly-ADPr antibodies and a few other things is now out in Nature Communications. Congrats to all the authors!!
www.nature.com/articles/s41...

AI badly needs a dose of skepticism Some scientists are too eager to believe their own claims

AI is powerful, but hype gives it pseudoscience vibes.

When claims are unfalsifiable, detached from reality, or driven by tools looking for problems, we risk undermining real progress.

Overselling AI does not accelerate science: It erode trust.

stevensalzberg.substack.com/p/ai-is-star...

Very cool! Congrats Aaron and all 🎉

Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇

Double kudos 🥳

A very exciting day-our work on the mechanism of AMD1 stalling is also out today, a great collaboration with the Baranov and Yordanova labs at UCC! Huge congratulations to Emir, first author on both papers! www.science.org/doi/10.1126/...

Kudos to @nadinelaguette.bsky.social team and all co-authors on this nice paper where our lab had a modest contribution! @viroscope.bsky.social 🔥

Congrats Kelley and all 🎉 what a tour de force 💪

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

Big congrats Ahmad and all! 🎉

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

Amen 🙏🏻 🤲🏻
A wise person once told me "all antibodies are non-specific until proven otherwise" I was just telling this to my students today 🤯

Excited to share our preprint exploring the structural, biochemical and in vivo properties of DRT7/UG10 reverse transcriptases which produce dsDNA using their primase and polymerase activities and provide broad-spectrum antiphage defense! www.biorxiv.org/content/10.6...

very unusual - a tRNA regulated anion channel

Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD NAC enables cotranslational N-terminal processing of histones H2A and H4 by recruiting MetAP1 and NatD at the ribosomal tunnel.

Last X-Mas, the ribosome gave you methionine,
but the very next day, MetAP took it away.
This year, to save histones from tears,
NatD gives you an acetyl group. ⭐️

Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu!

www.science.org/doi/10.1126/...

Chromatin buffers torsional stress during transcription During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...

@science.org Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...

The dark proteome: translation from noncanonical open reading frames

1⃣5'-UTR 2⃣3'-UTR small ORF/sORF
3⃣out-of-frame 4⃣In-frame overlapping ORF

Translating micropeptide <100aa, proteins distinct from canonical ORFs, or isoforms

#TrendsCellBio 2022
www.sciencedirect.com/science/arti...

✨New preprint!

🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬

🔗👇

The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin Accumulating evidence has connected the chemically unstable, DNA-damaging gut bacterial natural product colibactin to colorectal cancer, including the identification of mutational signatures that are ...

Colibactin-DNA interstrand crosslinks structure reveals DNA-damaging acitivity of colibactin that is linked to colorectal cancer #MicroSky www.science.org/doi/10.1126/...

❄️ RNA Modifications Newsletter – December 2025 issue no. 6

❄️ December RNA Modifications Newsletter is out! ❄️
rnamodifupdates.substack.com/p/rna-modifi...
❄️🔥RNA modifs = winter’s hottest adaptation toolkit. 🦠
#Ribosome #RNAbiology

From @kylecottrell.bsky.social lab

rnajournal.cshlp.org/content/31/1...

So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!

A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes | PNAS Natural genetic transformation is a conserved mechanism of bacterial horizontal gene transfer, which is directed entirely by the recipient cell and...

Congrats to @chgjohnston.bsky.social , Andreani, Radicella et al.!
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.

Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

New work from the Green and Beckmann labs on how ZAK recognizes collided ribosomes.

www.nature.com/articles/s41...

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.

To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...

Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/