🚨 Publication
Our letter to the editor is published in Alzheimer's and Dementia DADM @alzdemjournals.bsky.social
A French qualitative study on GPs' perceptives on AD BBM !
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Thank you so much for highlighting our recent work on #Parkinson synuclein SAA, DAT and MRI scans!
Very excited our paper was published back to back with a truly stellar and thorough companion paper by Brooker et al
doi.org/10.1002/mds....
And a humongous thank you all my coauthors and mentors @upenn.edu including Drs Andrew Siderowf, Dave Wolk and Ilya Nasrallah
This DAT/MRI mismatch in PD is associated with worse cognitive and olfactory impairment.
Participants with synuclein SAA- PD may have higher tau pathology biomarkers seen with Alzheimer copathology.
Honored to share our work on #Parkinsons in the journal Movement Disorders!
In sporadic and genetic PD, patients with synuclein SAA+ PD have more striatal DAT deficit relative to atrophy while those with synuclein SAA- PD have more striatal atrophy relative to DAT deficit.
doi.org/10.1002/mds....
Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neuropathology patterns www.biorxiv.org/content/10.64898/2025.12...
Congratulations Dr. Lasya Sreepada!
Official release 4.4.0 announced today 😌
Download: www.itksnap.org/download
Graphical overview: www.itksnap.org/new440
Happy segmenting!
Hello Bluesky! Welcome to the official Penn ADRD Trajectories, Copathology, and Heterogeneity (PATCH) Lab account for the labs of Drs. Paul Yushkevich, Sandhitsu Das, and David Wolk at the University of Pennsylvania. Stay tuned for updates about our presentations at AAIC25!
youtu.be/gpQ19OPUm34
New integration with nnInteractive (github.com/MIC-DKFZ/nnI...) in ITK-SNAP 4.4.0-alpha2 (itksnap.org) lets you turn scribbles into 3D segmentations in seconds. All thanks to an amazing new model from Fabian Isensee and colleagues at @helmholtzimaging.bsky.social!
Thrilled to see our team's work on the AInSights platform featured! Two years since we went live, and more exciting apps on the way. #AIinHealthcare #ClinicalDecisionSupport #HealthTech #AInSights #AIinHealthcare #ClinicalDecisionSupport #HealthTech
www.hcinnovationgroup.com/imaging/arti...
🚨Paper alert
Very happy to share our last work on #IntrinsicCapacity (IC) in dementia with Lewy bodies #DLB (n=154), compared AD (n=644)
👉DLB patients showed lower IC in all domains (locomotion, vitality, psychology, audition), requiring personalized interventions !
🔓 shorturl.at/EfrCX
SUPER BOWL CHAMPIONS!
THIS ONE’S FOR YOU PHILLY!
The mimicker of Alzheimer’s disease.
Progressive amnestic syndrome with:
1) Hippocampal atrophy
2) Older age ~ 80+
3) Negative AD biomarkers
• Caution with amyloid positivity common with aging
• Tau PET ideal but not covered
• FDG-PET medial > lateral Temporal hypometabolism = supportive
Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE)
alz-journals.onlinelibrary.wiley.com/doi/full/10....
#dementia #neuroscience #NeuroSky #MedSky #neurology
i think so! specific patterns on FDG PET and mismatch help predict a-synuclein and TDP-43 copathology in mixed AD+
Thank you!
Hi Monica, I’m a neuroimaging scientist and resident. Could you add me to the science feed? duongmdphd@bsky.social
scholar.google.com/citations?hl...
Thank you for the highlight and example case! With #LewyBody disease, posterior hypometabolism is often more prominent than atrophy. This could be related to changes in neuronal integrity of posterior networks by a-synuclein.
academic.oup.com/brain/advance-article/doi/10.1093/brain/awae352/7906681
Thank you!