Insights on #geroscience pre-clinical and clinical #trials to promote healthy #aging from the Intrinsic Capacity, #Frailty and Sarcopenia #Research Task Force 2025
#Ageing #IntrinsicCapacity #Sarcopenia #Science #Biology #Health
www.sciencedirect.com/science/arti...
Multi-trajectories of intrinsic capacity and their impact on incident #disability in community-dwelling older adults in Japan
#Geriatrics #Frailty #IntrinsicCapacity #Ageing #Aging #Health #Care
www.sciencedirect.com/science/arti...
Stanford-led THRIVE coalition secures up to $34.5m from ARPA-H to build FDA-grade intrinsic capacity score predicting 20-year outcomes.
vist.ly/4t6s8
#longevity #intrinsiccapacity #healthspan #preventivemedicine #biomarkers #ARPAH #FDA #agingpolicy
Want to dive a bit deeper yourself? In the US we tend to use the #4M framework: assess mind, mobility, medications, and what matters most to the patient.
The #WHO #IntrinsicCapacity framework of vision, hearing, vitality (nutrition), mobility, cognition, and mental health is another great tool.
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A #genome -wide association study identified 10 novel genomic loci associated with #IntrinsicCapacity.
👉Genetic architecture of #IC, laying the foundation for future #research on healthy #aging
#Geriatrics #Genes #Ageing #Health #Genetics
Full-text available here👇
academic.oup.com/biomedgeront...
si la gente se muestra cautelosa hasta el punto de inventar una capacidad intrínseca con el argumento de que la fragilidad está demasiado mal definida y es conceptualmente confusa, esperaría un mayor alboroto (o, más probablemente, una mueca de desprecio)
#IntrinsicCapacity
youtu.be/8eFOygUO7_Q?...
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I’m reframing my practice with the WHO “intrinsic capacity” lens—mobility, cognition, psychological well-being, vitality, sensory—layered onto disease-directed therapy + #intrinsiccapacity
www.nature.com/articles/s41...
A blood-based #epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and #lifestyle factors
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty
www.nature.com/articles/s43...
Excellent output from an #EAMA project to support the teaching and dissemination of #IntrinsicCapacity to medical students.
#Geriatrics #Ageing #Aging #Health #Care #WHO #PHC #PrimaryCare #MedSky
Please use and share the brochure below (English version):
www.eama.eu/Uploads/Inte...
🚨Paper alert
Very happy to share our last work on #IntrinsicCapacity (IC) in dementia with Lewy bodies #DLB (n=154), compared AD (n=644)
👉DLB patients showed lower IC in all domains (locomotion, vitality, psychology, audition), requiring personalized interventions !
🔓 shorturl.at/EfrCX
Do bone and muscle density/mass and function play essential roles in the #IntrinsicCapacity (IC) domains? What happens with IC when #osteosarcopenia occurs in older persons? New call for papers from the J of #Gerontology Medical Sciences: academic.oup.com/biomedgeront... @geronsociety
Our symposium on the role of the #musculoskeletal system as the main determinant of #IntrinsicCapacity @ICFSRcongress was a total success. Presentations from @tilda_tcd, Toledo (@IvanBaltasar) & Geelong as part of the @CIHR_IRSC funded #ThriveProject led by @RIMUHC1 @McGill_DOM
Great presentation on #IntrinsicCapacity by our geriatrician and research fellow Wayne Lok @ICFSRcongress in Toulouse. First report from our international Thrive Project led by our team at @RIMUHC1. Much more to come!
Very nice paper. Congratulations!
To me, a critical issue in #frailty (and #IntrinsicCapacity) is understanding the limited importance of tools in capturing the condition of interest.
We need to contextualise and be pragmatic. One (tool) will never fit all (globally)
#Geriatrics #Health #Care
