UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism - preLights UFMylation, discovered for the first time in mitochondrial proteins, is found to keep pyruvate dehydrogenase activity and downstream glucose oxidation in check.

UFMylation, discovered for the first time in mitochondrial proteins, is found to keep pyruvate dehydrogenase activity and downstream glucose oxidation in check.

Hannah Pletcher (@nieminm.bsky.social lab) highlights work from @rjdlab.bsky.social

#preLight ⬇️
prelights.biologists.com/highlights/u...

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Last 2 weeks of research on #Mitochondria in #Health and #Disease! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

Among highlights 👇
www.nature.com/articles/s41...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

1,1-Diethoxyethane enhances aerobic respiration in human mitochondria via activation of AMP-activated protein kinase - Communications Biology 1,1-Diethoxyethane, a flavoring component of wine, was revealed to regulate energy homeostasis by activation of AMPK and enhancement of aerobic respiration. 1,1-DEE is potentially beneficial for human...

🍷🫀In this new Communications Biology article, 1,1-Diethoxyethane, a flavoring component of wine, was revealed to regulate energy homeostasis by activation of AMPK and enhancement of aerobic respiration. 1,1-DEE is potentially beneficial for human health and disease. doi.org/10.1038/s420...

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A new weekly selection of #anticancer #therapy and #metabolic #reprogramming! Enjoy the reading 🐣

biomed.news/bims-meract/...

🙏 @biomednews.bsky.social

Really nice to see this work published!!
Huge congrats to @jellevda.bsky.social and all the team!! 🥳👏

Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!

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Happy Easter! Don't miss the latest publications on computational and analytical methods for #metabolomics and #lipidomics

biomed.news/bims-metlip/...

Pre-sorted by @biomednews.bsky.social

Happy Easter eggficionados!! Celebrate it with the a fantastic issue of #cebooc here!

biomed.news/bims-cebooc/...

Cytoplasmic lattices are on fire these days, here another great structural insight: pubmed.ncbi.nlm.nih.gov/41917274/

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#Autophagy and #mTOR papers from last week, enjoy with a chocolate egg or two 🐣

biomed.news/bims-auttor/...

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Easter edition of #Mitochondria in #Health and #Disease!
🐰🐣
biomed.news/bims-mitdis/...

@gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social

Perling drives mtDNA nucleoid distribution
www.science.org/doi/10.1126/...

Programmable soft matter: Shaping function Living organisms adapt through dynamic shape changes driven by integrated sensing and feedback. This review outlines advances in polymer-based shape-morphing materials programmed to autonomously respo...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...
via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: programmable soft matter, de novo-designed protein biomaterials, gradient multinozzle 3D Printing, bioelectronic interfaces, & more 🧪

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology Mitochondrial DNA (mtDNA) is not static but undergoes a regulated ‘life cycle’ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...

A bit late to the party, but delighted to share our mini-review on the mitochondrial (mt)DNA life cycle, highlighting emerging mechanisms of mtDNA degradation!

Always a pleasure to work with the fantastic @lctabara.bsky.social !!!

Have a look 👇
www.nature.com/articles/s41...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting new 'immunometabolism' method:

Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

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Weekly summary of the latest and greatest computational and analytical methods for metabolomics and lipidomics. Check it out!

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

https://www.nature.com/articles/s42255-026-01476-1

Latest published research on #Mitochondria in #Health and #Disease! 📚 #week13
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis

It was a great experience to be in the final of the #FameLab for the northwest region. I tried to squeeze why I’m in a mitochondriac into 3 minutes. Thanks to the organisers, judges, audience and other contenders. I feel like we’re a little family now #mitochondria

Mitochondrial control of glycerolipid synthesis by a PEP shuttle https://www.cell.com/cell/abstract/S0092-8674(26)00224-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867426002242%3Fshowall%3Dtrue

#Mitochondria in #Health and #Disease - last 2 weeks of published research 📚:
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito control of glycerolipid synthesis by a PEP shuttle
www.cell.com/cell/abstrac...

Mitochondrial control of glycerolipid synthesis by a PEP shuttle SLC25A35 is revealed as the mitochondrial PEP exporter that licenses glycerolipid synthesis in lipogenic cells, linking mitochondrial energetics to lipid production. Mitochondrial PEP flux drives glyc...

Mitochondrial control of glycerolipid synthesis by a PEP shuttle: Cell www.cell.com/cell/fulltex...

MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

Last 2 weeks of literature on #Mitochondria in #Health & #Disease! 🤍 💚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Vit B2 and B3 nutrigenomics reveals a therapy for NAXD disease
www.cell.com/cell/fulltex...

Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...

Our story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look!

www.cell.com/molecular-ce...

Figure 9: Anti-influenza mechanism of action of cis-aco. DOI: 10.1038/s44321-026-00379-8.

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...

A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species - Nature Metabolism Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

Most recent collection of papers on #Mitochondria in #Health and #Disease!
#week7 #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...

Sub-second volumetric 3D printing by synthesis of holographic light fields - Nature A new method is described that uses a periscope to generate high-speed, high-resolution projections of light fields, enabling sub-second volumetric 3D printing of millimetre-scale objects without rota...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: sub-second volumetric 3D printing, fluorescently labeled gradient hydrogels, learning nature's assembly language with polymers & more 🧪

Good morning! this week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation www.science.org/doi/10.1126/...

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"For everything you do, there will be a last time that you do it."-William B. Irvine

Mechanisms and disease relevance of mitochondrial translation in humans Nature Reviews Molecular Cell Biology, Published online: 13 February 2026; doi:10.1038/s41580-026-00948-2This Review discusses new insights into the intricate regulation of mitochondrial protein synthesis, the pathological consequences of its dysfunction in cancer and immunity, and the complexity of therapeutic targeting of mitochondrial translation.

New Online! Mechanisms and disease relevance of mitochondrial translation in humans