SPINA-DI: Fasting-Based Disposition Index For Diabetes Diagnosis - Medical News Observer A recent study in the Journal of Diabetes introduced a novel method for diabetes diagnosis: the fasting-based disposition index (SPINA-DI).

medicalnewsobserver.com/2024/01/22/s...

Bolies Modell der Insulin-Glukose-Homöostase auf dem Analogrechner THE ANALOG THING. Im Hintergrund ein Oszilloskop zur Ausgabe der Daten und ein MacBook Air, das für die Simulation nicht notwendig ist, aber erklärende Informationen zeigt (aus meiner Vorlesung "Metabolische Kybernetik und Systemendokrinologie"). Model of insulin-glucose homeostasis by Victor W. Bolie (1960 and 1961) simulated on a modern analog computer (anabrid THE ANALOG THING). In the background an oscilloscope by PeakTech and a MacBook Air M2 illustrating supporting information.

Hier ein Beispiel für eine berühmte Simulation mit einem #Analogrechner: Das Modell der #Insulin-Glukose-Homöostase von Bolie (1960). Dieses Modell hatte einen enormen Einfluss auf unser Verständnis des #Diabetes mellitus und lässt sich mit modernen Analogrechnern jetzt wieder direkt reproduzieren.

Screenshot of SimulAdren 2.0 (Rubycon) on macOS 13.7 (Ventura).

Screenshot of SimulAdren 2.0 (Rubycon) on Windows 11

Screenshot of SimulAdren 2.0 (Rubycon) on Fedora Linux 38

#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation.

simuladren.sourceforge.io
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Two bar plots from the paper: Yearly numbers of publications in PubMed from 1965 to 2025 on mathematical modelling in endocrinology and diabetes with (left) and without (right) machine learning. Search terms were “(“mathematical modelling” OR “computer simulation” OR “machine learning”) AND (endocrinology OR endocrine OR hormone OR hormonal OR diabetes)” for the left plot and “(“mathematical modelling” OR “computer simulation”) AND (endocrinology OR endocrine OR hormone OR hormonal OR diabetes)” for the right plot. The left chart shows a dramatic increase, peaking sharply in the year 2025 at nearly 3000 publications. The right chart shows moderate growth with peaks around four hundred around the year 2025.

Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy.

pubmed.ncbi.nlm.nih.gov/41852474/
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SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 (left) and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7 (right)

30 years of #SimThyr in #Marchintosh 2026: #SimThyr 2.0 on a Mac SE with Mac OS Antares 6.0.7 and SimThyr 4.0.6 on a MacBook Air with macOS Ventura 13.7.

Thanks to the fact that the code was based on the #Pascal programming language, the software is highly portable, but runs with full native speed.

Screenshot of Trndi on Fedora Linux, showing a glucose concentration of 10.8 mmol/l

#Trndi is a #glucose monitoring application written in #Object_Pascal. It fetches interstitial sugar readings from continuous glucose monitors (CGM) via different APIs and shows them on the desktop. It also presents a trend over time, colouring, and JavaScript extensions.

trndi.app

Figures from the defining paper showing the hyperbolic relationship between insulin sensitivity and pancreatic beta-cell function, based on computer simulations in Object Pascal and statistical evaluation of big datasets.

The theory underlying this advanced method was developed based on computer simulations written in #Object_Pascal.

pubmed.ncbi.nlm.nih.gov/38169110/
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www.livivo.de/doc/M38169110

#Pascal #programming

New calculation offers simple and reliable early prediction of diabetes Diabetes often remains undetected until it has already damaged organs or nerves. This is partly due to the fact that diagnosis at an early stage is time-consuming and difficult.

Diagnosis of #diabetes mellitus and #prediabetes: A simple calculation may be better than a complex test.

🧪 🩺 #MedSky @medsky.social #Endosky #Endocrinology

medicalxpress.com/news/2024-01...

CyberUnits Bricks: Screenshot of a demo app for a feedback loop with a dead-time element.

CyberUnits Bricks: Screenshot of unit tests for the solver unit.

#CyberUnits Bricks has been released in version 2.1.0.

This version introduces a proportional-integral (PI) block, scaling for systems diagrams, a solver for algebraic equations, extended ASIA elements, additional demo programs, and bug fixes.

cyberunits.sf.net
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Wirkungsgefüge eines Regelkreis-Modells der Insulin-Glukose-Homöstase

Metabolische Phänotypisierung durch mathematische Modellierung der #Insulin-Glukose-Homöostase

Mathematische Modelle und Simulationen der Insulin-Glukose-Homöostase sind nützlich, da sie physiologische Erkenntnisse liefern und klinische Entscheidungen unterstützen.

www.doccheck.com/de/detail/ar...

Previsione precoce semplice e affidabile del diabete. Il diabete spesso rimane inosservato finché non ha già danneggiato organi o nervi. Ciò è in parte dovuto al fatto che la diagnosi in fase precoce è difficile e dispendiosa in termini di tempo. Un t…

Previsione precoce semplice e affidabile del diabete

blogpinali.wordpress.com/2024/01/23/p...

Screenshot of the web site of the Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" in Frontiers in Systems Endocrinology

Are you researching #endocrine #feedback control systems?

Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission.

www.frontiersin.org/research-top...

#endocrinology #cybernetics

#SimulaBeta and #SimThyr provide the theoretical foundations for this revolutionary approach.

Screenshot of SPINA Carb 5.1.0 Cycline on macOS 15.5 Sequoia, showing two Windows (entry and results).

SPINA Carb 5.1.0 Cyclone has been released in its final version.

#SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes

sourceforge.net/projects/spi...

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Screenshot of release candidate 3 of SPINA Carb 5.1 Cyclone on mac OS 15.5 Sequoia

Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux.

sourceforge.net/projects/spi...

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#SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA

Screenshot of SPINA Carb 5.1.0 (Cyclone) RC2 on macOS Ventura 13.7.5.

Release candidate 2 of #SPINA_Carb is available for testing.

sourceforge.net/projects/spi...

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Screenshot of SPINA Carb Release Candidate 1 for macOS

After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing.

sourceforge.net/projects/spi...

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Table showing endotypes of insulin-glucose homeostasis in patients with hidradenitis suppurative (HS or acne inversa) and different expressions of haptoglobin concentration. In persons with HS and a high haptoglobin concentration, insulin sensitivity (SPINA-GR) and beta-cell function (SPINA-GBeta) are similar but combine to provide a reduced disposition index (SPINA-DI).

Plot of SPINA-GBeta versus SPINA-GR in patients with HS and controls: The majority of patients with HS and diabetes are faced with rather low insulin sensitivity and a lack of dynamic compensation via pancreatic beta-cell function, resulting in a reduced disposition index.

#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin.

pubmed.ncbi.nlm.nih.gov/40217596/

Graphical Abstract: This novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or due to primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.

Sample title page of the Journal of Diabetes

I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes.

onlinelibrary.wiley.com/doi/toc/10.1...

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Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der Insulintherapie bei Typ 1-Diabetes

Sind Sie eine Person mit Typ 1 Diabetes und interessiert daran, die Auswirkungen von verschiedenen Insulinpräparaten auf Ihren Blutzucker nach den Mahlzeiten zu erforschen? Haben Sie eventuell sogar Probleme mit Blutzuckerschwankungen nach der Mahlzeit? Wenn ja, könnten Sie der Schlüssel zu einer Personalisierung der Insulintherapie bei Menschen mit Typ 1 Diabetes sein. Sprechen Sie uns an! Kontaktieren Sie uns unter: insulinstudie@klinikum-bochum.de oder 0234-509-57813

Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1.

www.klinikum-bochum.de/fachbereiche...

In an unselected population sample (NHANES 2009/2010), persons with low thyroid's secretory capacity (SPINA-GT) and total step-up deiodinase activity (SPINA-GD) face significantly worse survival over 10 years.

In an unselected population sample (NHANES 2009/2010), persons with low beta-cell function (SPINA-GBeta) and static disposition index (SPINA-DI) are faced with significantly shorter survival over 10 years.

The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality.

doi.org/10.53201/LEI...

Graphical abstract: The novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.

The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺

pubmed.ncbi.nlm.nih.gov/38169110/
doi.org/10.1111/1753...

Simulation speed with implementations in different programming languages. Shown is the time needed to simulate a first-order linear feedback loop (A) and a zeroth-order MiMe-NoCoDI loop (B) dependent on the number of iterations (proportional to simulated time, abscissa) based on implementations of the simulation program and the CyberUnits Bricks library in S, Python, Swift, C++ and Object Pascal. The ordinate is logarithmically scaled and represents the mean of 10 replications of each number of iteration steps.

Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++. 🧪🩺

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Urkunde über den Heinz von Foerster-Preis der Deutschen Gesellschaft für Kybernetik, Informations- und Systemtheorie e. V. an Johannes W. Dietrich

Die Deutsche Gesellschaft für #Kybernetik, Informations- und #Systemtheorie hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen.
Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.

Gratulation an @drjwdietrich.bsky.social für den Heinz-von-Foerster Preis für Organisationskybernetik!

Simple and Reliable Early Prediction of Diabetes A simple blood test could perform better than a complex test thanks to mathematical modeling.

A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal.

Today, this innovative approach is covered by all major press agencies and news channels all over the globe.

news.rub.de/english/pres...

4 Plots showing the hyperbolic relation between SPINA-GBeta (a measure for beta cell function) and SPINA-GR (reconstructed insulin receptor gain as a measure for insulin sensitivity). (A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI. The ability of dynamical beta cell compensation is partly lost in prediabetes.

Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...

Screenshot of SimulaBeta 3.1.2 on macOS Ventura 13.4.1

#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0.

simulabeta.sourceforge.io
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