A new study shows how different regulatory genetic elements coordinate the activity of a key developmental gene. The findings could explain subtle differences seen in patients with congenital limb malformations, for which the underlying disease mechanisms often remain unknown.
Read more: ⬇️
@nataliabenetti.bsky.social @stemundi.bsky.social @lilaallou.bsky.social @molgen.mpg.de
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@mrc-lms.bsky.social
A new study shows how different regulatory genetic elements control when a key developmental gene is active in the body.
The findings could explain subtle differences seen in patients with congenital limb malformations, for which the underlying disease mechanisms often remain unknown.
New research in Nature Communications identifies an overworked cog in the cellular machinery of tumour cells that could be targeted by new treatment options for an aggressive class of cancers caused by mutations in Ras genes.
@mrc-lms.bsky.social @imperialmed.bsky.social @cancerresearchuk.org
If you are a graduate student or postdoc working in redox biology, metabolism, mitochondrial signaling, oxidative stress or related fields, follow the link below and find out more!
#RedoxBiology #GRS #GordonResearchSeminars #OxidativeStress #Metabolism #ScientificCommunity #EarlyCareerResearchers
The GRS is immediately followed by the larger Gordon Research Conference (GRC) organised by @elizabethveal.bsky.social and @giedroclab.bsky.social
It’s a great opportunity to engage with the wider redox biology community.
This trainee-focused meeting will feature short talks, poster sessions, interactive discussions, and a career panel – offering a fantastic opportunity to connect with peers and senior scientists in the field. Discussion leaders include @hozumim.bsky.social, Tobias Dansen, and Christine Chio.
Great opportunity for early career researchers in redox biology!
The Gordon Research Seminar (GRS) on Thiol-Based Redox Regulation and Signaling, organised by our own @claudialennicke.bsky.social (MRC LMS) and Taylor Covington (Harvard Medical School), is happening in Barcelona on the 11-12 July.
Register to The PALS Summer School in TranscriptOMICS
👉 Before April 15
And learn to
Integrate Chromatin Accessibility w 3D Genomics
w hands-on session by Luminita Ruje from @mrc-lms.bsky.social
@scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social
www.trippus.net/summerschool...
This Summer the LMS will be hosting 2 medical students as part of our Undergraduate Summer Programme!
These are fully-funded opportunities for medical students to gain hands-on lab experience and start their careers as Clinician Scientists.
To apply follow the link below:
Applications for our Undergraduate Summer Programme are now open!
We have 5 fully-funded research projects running from 06 July to 28 August.
To apply follow the link below:
lms.mrc.ac.uk/work-and-stu...
It was great to organise this retreat with a topical theme. Would recommend!
At the retreat the students explored how to navigate communication breakdowns, better articulate research at the policy level and build lasting credibility within the wider scientific community.
The day was a massive success, thanks again to the organisers for a fantastic day!
A huge thank you to the speakers for making the day such a success:
• Dr Jon Roozenbeek @cam.ac.uk
• Tracey Brown OBE @senseaboutsci.bsky.social
• Dr Nita Pillai @senseaboutsci.bsky.social
• Dr Praveen Paul @pintofscience.uk
• Sir David Spiegelhalter @cam.ac.uk
The retreat's theme was “Science (Mis)communication – Facts, Fiction, and the Stories In-between” and focused on how information is communicated, interpreted and sometimes distorted.
People enjoying themselves at the LMS PhD Student Retreat
The organisers and speakers of the event
The MRC LMS PhD Cohort
Congratulations @johnbergqvist.bsky.social, @klaudiastanik.bsky.social and Shamin Tahasildar for organising this year's PhD Student Retreat!
🧬 It’s not just #DNA code that matters – it’s the shape.
Scientists from @imperialinfect.bsky.social, @mrc-lms.bsky.social & @sheffielduni.bsky.social show that twisting DNA can trigger #CRISPR errors, opening the door to safer #GeneEditing.
Read more 👇 www.imperial.ac.uk/news/article... #Genomics
Research from Imperial, @mrc-lms.bsky.social, &
@sheffielduni.bsky.social reveals that the twisting of DNA could play a role in correcting CRISPR errors. 🧬
The team captured interactions between CRISPR and DNA, providing insights that could help eradicate errors.
www.imperial.ac.uk/news/article...
And that’s a wrap! From all of us @bsdb.bsky.social - thank you everyone for making this a very special meeting, from Molecules to Morphogenesis
Excited to share our story published today @nature.com!
🔗 www.nature.com/articles/s41...
Read about how we uncover the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets!
Have a quick read of some of the key events in the thread below🧵:
@qmsmith.bsky.social @nature.com @imperialcollegeldn.bsky.social @imperialmed.bsky.social @sheffielduni.bsky.social
New research in Nature shows that the physical twisting of DNA plays an important role in DNA editing mistakes made by CRISPR.
Using nanometer-sized circles of DNA, scientists captured never-before-seen interactions between CRISPR & DNA, providing insights that could eradicate errors altogether.
Why do some #cancer cells develop treatment #resistance? The answer may lie in hidden “storage hubs” inside #tumour cells, which create uneven drug exposure across tumours, according to new #research led by @louisefets.bsky.social from 🇬🇧 @mrc-lms.bsky.social.
Our latest paper in Nature Communications reveals self-luminescent plants that light up in response to pests and pathogens — no chemicals or specialist imaging needed.
Using hormone-responsive bioluminescence, we can watch plant immunity unfold in real time with an ordinary camera.
Research led by Academy of Medical Sciences Professorship awardee Juanma Vaquerizas on the front cover of Nature Genetics – great to see this work gaining global attention
The professorship scheme is funded by the Department for Science, Innovation and Technology.
@mrc-lms.bsky.social @imperialcollegeldn.bsky.social @imperialmdr.bsky.social @imperialmed.bsky.social @cancerresearchuk.org @louisefets.bsky.social
New research shows cancer drugs can accumulate in hidden “storage hubs” inside tumour cells, creating uneven drug exposure across tumours.
This could help explain why some patients respond better to treatment than others & may open avenues towards more personalised therapy approaches in the future.
A nice thing happened.. We got the cover of Nature Genetics! 😊🎉
The spheres trace nuclear stages through early embryogenesis, with color bursts capturing the diverse events that shape genome architecture.
Art done by my friend and very talented artist @christophewirtz.bsky.social 🎨
@imperialcollegeldn.bsky.social @imperialmed.bsky.social @acmedsci.bsky.social @natgenet.nature.com @ukri.org