Together, we propose a unified model for BREX and BR systems, defining BREX-based prokaryotic immunity as a multi-layered sensing–modifying–restricting defense architecture. #RMlikedefensesystems #Evolution #BREXdefense

We further unexpectedly uncover a highly sporadic/hidden composite anti-invader system that integrates BREX with HerA/FtsK and Dpd modules. #BREXarchitecture #Comparativegenomics

Beyond core components, we identify for the first time an extensive, diverse repertoire of auxiliary and backup effectors--consistently associated with BREX and BR systems--reinforcing restriction and countering phage anti-defense strategies #RMlike #antiphage #armsrace

Expanding the landscape of BREX diversity: uncovering multi-layered functional frameworks and identification of novel BREX-related defense systems Abstract. Despite extensive scrutiny of BREX systems, several overarching questions persist regarding the functional modalities of individual components an

Happy to share our article On BREX @narjournal.bsky.social We here redefine the core of BREX, uncover hidden functional domains, and identify 3 new BREX-related(BR) RM-like defense systems, expanding the BREX landscape. @rakesh-raj21.bsky.social #Phagedefense #BREX #prokaryoticimmunity

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