Happy to have been part of this work with Karen Hastings and team at the Univ of Arizona quantifying the impact of structure on neoAg immunogenicity. Kudos to @chadbrambley.bsky.social and the others for their awesome work. Look for modeling to improve neoAg prediction!
jitc.bmj.com/content/13/1...
Photograph of Phillip Dettmer's "Immune", taken with an airport jet bridge in the background.
Let's go home
I had a blast presenting our work on T cell mimotope discovery! A huge thank you to @epivax.bsky.social for hosting such a great meeting and inviting us to speak. I don't want to leave Rhode Island!
It was a cold and snowy one, but today we stood up for science! The fight is just beginning though, don't let them dismantle OUR research.
Ok, I've GOT to share this one. Genius might be a tad strong, but who am I to refute my boss haha
PDB viewer integration in obsidian to look at PDB structures within a markdown file Source: https://www.linkedin.com/posts/leonardo-castorina_protein-activity-7285934811066593280-vdBd
PDB viewer integration into Obsidian - I need this yesterday (source in alt text)
In a world of Kid Rocks and Carrie Underwoods, be a Woody Guthrie.
Can NOT believe we pulled it off in regulation! #GoIrish #NotreDame
Marcus Freeman might just be the smartest coach in the game. This was a fun one!
#goirish 🍀
#immunosky Anyone else wake up to good news from grant Santa? This one's an F32 fellowship, to help take on TCR cross reactivity. Honored and excited to be working on this and grateful for the support!
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Oh no argument here. Truly just pointing out that other molecules are technically supported. Excited to see how it develops in the future. Definitely a lot of potential!
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Student: I want to master #Linux, but I can’t grow a beard.
Master Foo: Once you master linux you become the beard.
Upon hearing this, the student was enlightened.
The really cool part is that it's currently the worst it's ever going to be. It will only get better from here!
This is incorrect. While proteins are the focus and the star of the show, Alphafold does accept DNA, RNA, and even small molecule ligands as inputs. It even outperforms SOTA alternatives on RNA structures according to some metrics. Not as effective on those, to be sure, but it is not 'protein only.'
Great thread. It seems like there's a lack of awareness of the sheer breadth of AI applications among the general public. Image generators and chatbots = AI = bad. But in reality it's a conversation that needs nuance, and condemning "AI" unilaterally may do far more harm than good.
Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1101/2024.11....
Protein LMs, genomic LMs, and chemical LMs, to name only a few. Incredible potential to transform medicine (already are), and they're based on the same tech as any language model. And all are technically subsets of machine learning. So, not completely different, to be fair.
Will save more time that asking ChatGPT!
🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social
I called both Wilson and Rutherford counties home during grad school. Not exactly surprised by my former neighbors, but I am both ashamed and embarrassed for them.
I think this will do nicely for my inaugural skeet. Thanks boss for the shout out! Eagerly (and cautiously) excited to get this thing funded. We have work to do!
#immunosky