Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis Abstract. Cathepsin K inhibitors are well known for their inhibitory activity against bone resorption but were also reported to preserve bone formation in

New paper out in JBMRPlus !
Using a time-lapse co-culture approach with #osteoclasts and reversal cells, we show that reversal cells prefer pits over trenches, but that intermediate #CatK inhibition boosts their attraction and maturation into #osteoblasts.
track.smtpsendmail.com/9032119/c?p=...

@osteoporosis-nl.bsky.social

Do we make the best of the synergistic potential between basic and clinical scientists? This is the topic we as members of the Basic and Clincal Science Action Groups of @ectssociety.bsky.social (ECTS) and ECTS Academy discuss in this paper!
rdcu.be/d9WxL
@asbmr.bsky.social @ifmrs.bsky.social

It is "osteoclast appreciation day" every day in my lab 😁

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Stage-specific modulation of multinucleation, fusion, and resorption by the long non-coding RNA DLEU1 and miR-16 in human primary osteoclasts - Cell Death & Disease Cell Death & Disease - Stage-specific modulation of multinucleation, fusion, and resorption by the long non-coding RNA DLEU1 and miR-16 in human primary osteoclasts

If you are interested in the impact of long non-coding RNA and uRNA on #human #osteoclast differentiation and #bone resorption, you may be interested in our paper published late last year - Open Access
www.nature.com/articles/s41...