NPC remodeling drives #osteoclastogenesis by reshaping #chromatin architecture and epigenetic accessibility, with Nup133, Dnmt3a, and Ezh2 emerging as key regulators of #osteoclast differentiation and promising therapeutic targets for #BoneDiseases.
Read: doi.org/10.1016/j.ge...
#SingleCellTranscriptomics of #bonemarrow in #Type2Diabetes reveals impaired #cytokinesignaling, reduced #osteoclast activity, and diminished Cd36+ precursor differentiation, driven by dysregulated AP-1 transcription factor activity.
#OpenAccess: doi.org/10.1016/j.ge...
#Piezo1‑mediated Ca²⁺ signaling in PDLCs under heavy force reduces mitochondrial Ca²⁺ influx, suppresses cGAS‑STING activation and #osteoclast differentiation, slowing #OrthodonticToothMovement, highlighting Piezo1/STING as therapeutic targets.
#OpenAccess: doi.org/10.1016/j.ge...
#Phosphatidylserine exposure and #annexin A5 weaken the #actin cortex in #osteoclast fusion, say Evgenia Leikina, Michael Kozlov, Leonid Chernomordik and colleagues (National Institutes of Health): rupress.org/jcb/article/...
#Membrane #lipid #CellSignaling #Biophysics
Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid #CellSignaling
In @jcb.org, Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid
This study highlights mechanical force-induced Piezo1 in PDLCs as a key regulator of #Osteoclast activity and bone remodeling during OTM, offering a potential therapeutic avenue to accelerate tooth movement. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Read the latest article in JHC: "Alendronate Alters the Release of EVs by Raw 264.7 Osteoclasts."
Click to read: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
Moesin strikes an "Actin"g G-balance to regulate #osteoclast fusion and activity. Marwa Zeyad and Yousef Abu-Amer @washumedicine.bsky.social highlight new work from the @chrisverollet.bsky.social group (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
Moesin controls cell–cell fusion and #osteoclast function, say Ophélie Dufrançais, Brigitte Raynaud-Messina, Christel Vérollet (@chrisverollet.bsky.social) and colleagues @ipbstoulouse.bsky.social: rupress.org/jcb/article/...
#Physiology #Cytoskeleton #Actin
Spotlight @jcb.org: Zeyad & Abu-Amer @washumedicine.bsky.social highlight work by Dufrancais @chrisverollet.bsky.social et al. (rupress.org/jcb/article/...) revealing a role of tunneling nanotubes in moesin-mediated #osteoclast fusion & regulation of #osteoclastogenesis. rupress.org/jcb/article/...
Spotlight: Zeyad and Abu-Amer @washumedicine.bsky.social highlight work from Dufrancais @chrisverollet.bsky.social et al. (rupress.org/jcb/article/...) revealing a role of tunneling nanotubes in moesin-mediated #osteoclast fusion and regulation of #osteoclastogenesis. rupress.org/jcb/article/...
Read the latest article in JHC: "Alendronate Alters the Release of EVs by Raw 264.7 Osteoclasts."
Click to read: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
Hitora et al. (2024) - AI in drug screening
🧪🤖 Our work in J Nat Prod applies machine learning to screen osteoclast differentiation inhibitors from natural products! AI accelerates drug discovery for bone-related diseases. 🦴🔬
🔗 doi.org/10.1021/acs....
#DrugDiscovery #MachineLearning #Osteoclast
If you are interested in the impact of long non-coding RNA and uRNA on #human #osteoclast differentiation and #bone resorption, you may be interested in our paper published late last year - Open Access
www.nature.com/articles/s41...
