NPC remodeling drives #osteoclastogenesis by reshaping #chromatin architecture and epigenetic accessibility, with Nup133, Dnmt3a, and Ezh2 emerging as key regulators of #osteoclast differentiation and promising therapeutic targets for #BoneDiseases.

Read: doi.org/10.1016/j.ge...

Researchers identify NFIA as a key regulator of #BoneHomeostasis, and its loss in mesenchymal progenitors disrupts bone balance by enhancing resorption over formation, linking NFIA deficiency to age-related #osteoporosis. #osteoclastogenesis

#OpenAccess: doi.org/10.1016/j.ge...

Spotlight @jcb.org: Zeyad & Abu-Amer @washumedicine.bsky.social highlight work by Dufrancais @chrisverollet.bsky.social et al. (rupress.org/jcb/article/...) revealing a role of tunneling nanotubes in moesin-mediated #osteoclast fusion & regulation of #osteoclastogenesis. rupress.org/jcb/article/...

Spotlight: Zeyad and Abu-Amer @washumedicine.bsky.social highlight work from Dufrancais @chrisverollet.bsky.social et al. (rupress.org/jcb/article/...) revealing a role of tunneling nanotubes in moesin-mediated #osteoclast fusion and regulation of #osteoclastogenesis. rupress.org/jcb/article/...

Dufrançais, Raynaud-Messina, @chrisverollet.bsky.social et al. show that moesin, a member of the ERM proteins, plays a negative regulatory role in #osteoclastogenesis. rupress.org/jcb/article/...

#Physiology #Cytoskeleton #Actin

In @jcb.org, Dufrançais, Raynaud-Messina, @chrisverollet.bsky.social et al. show that moesin, a member of the ERM proteins, plays a negative regulatory role in #osteoclastogenesis. rupress.org/jcb/article/...

#Physiology #Cytoskeleton #Actin

This study shows that miR-378 boosts #Osteoclastogenesis via the NF-κB pathway, leading to TGFβ-impaired #Osteogenesis post-#Ovariectomy, suggesting that miR-378 inhibitors could be a promising tool for # Osteoporosis diagnostics & therapy. #medsky
#OpenAccess:
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