#Piezo1‑mediated Ca²⁺ signaling in PDLCs under heavy force reduces mitochondrial Ca²⁺ influx, suppresses cGAS‑STING activation and #osteoclast differentiation, slowing #OrthodonticToothMovement, highlighting Piezo1/STING as therapeutic targets.

#OpenAccess: doi.org/10.1016/j.ge...

New research on orthodontic tooth movement!

This new study underscores the pivotal role of Piezo1 in modulating [Ca2+]m levels under #mechanicalforce (MF) stress, providing new insights into the mechanisms involved in accelerating #Orthodontictoothmovement (OTM). #medsky

buff.ly/OupucVL

Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation

This new study underscores the pivotal role of Piezo1 in modulating [Ca2+]m levels under #mechanicalforce (MF) stress, providing new insights into the mechanisms involved in accelerating #Orthodontictoothmovement (OTM). #medsky

#OpenAccess: www.sciencedirect.co...