In triple-negative breast cancer, sensory neurons activate cancer-associated fibroblasts to secrete collagen, thus stimulating a dense extracellular matrix that drives immune exclusion @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
I am incredibly grateful for this collaboration with the brilliant and fabulous Dr. Samantha Yee. Her perseverance and leadership made this work possible, and it is exactly the kind of science-driven teamwork we need right now.
If you are interested in new ways for targeting chemoresistant ER+ breast cancer, the unexpected and powerful role of tumor microenvironment, and the effects of combinatorial treatment with docetaxel and FDA-approved tocilizumab, I highly recommend this as your weekend reading.
What happens when two postdocs connected through an amazing #NCI #F99K00 grant program, really like working together? You get a paper we are truly proud of - now live on bioRxiv!
#BreastCancerResearch #CancerBiology #TranslationalResearch #NCI #IL6 #Tocilizumab #Docetaxel #Organoids #UVA #UVABME
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Excited to share one of the first papers to link #lncRNA #structure to its function in #cancer!
We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function.
www.sciencedirect.com/science/arti...
It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
Congratulations, Paweł! Great and impactful story.
🎉 Incredibly proud to share my first-author paper in
@nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️
🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬
👉Read the story: bit.ly/3XYvQkI
#Nature #mRNA
Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it.
Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Congratulations to all authors, especially Natalia! Great work!
#ninetails #nanopore #polyA #mRNA #vaccines
This is crazy shit. Here is early work on a very promising mRNA vaccine against pancreatic cancer.
Is cancer treatment anti-American now?
🧪
www.nature.com/articles/s41...
Have you wondered what the @elife.bsky.social peer-review process looks like? Feel free to see our responses to the reviewer comments on our manuscript "DNA replication in primary hepatocytes without the six-subunit #ORC". I enjoyed the process and highly recommend it!
One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”
This is an exciting piece of research that brings us closer to an informed choice of therapy for individual patients. I am grateful to my PI and all collaborators for letting me learn how to start a translational project and how far it can reach. Thanks to UVA Engineering for highlighting our work!
Submitting in June and so happy to see the extension!
One of my favorites! :)
#Rstats trick: use case_when(). I use it almost every week. No more nested if else
gist.github.com/crazyhottom...
Believe me, I was shocked 😆
Thank you, Will! Excited to see you soon :)
Thank you! All the best to you!
Thank you, Mariusz! :)
We have not tested it in this model but you may be interested in another preprint from our lab.
In short, MCM2-7 is still loaded at comparable rates in G1 phase to license reserve origins and in the same S phase to permit re-replication in human cancer cell lines lacking ORC.
These findings open new avenues for understanding DNA replication and cellular adaptation, with potential implications for cancer research and regenerative medicine. Grateful to my co-authors and collaborators for their invaluable contributions. Excited to see where this leads! (4/4)
