📢 Welcome to issue 4 of RSC Chemical Biology!
🦠 This issue features articles on the roles of lipid droplets in metabolic signalling, siRNA chemical modification strategies, TRK fusion-positive cancer targeting PROTACs and more!
➡️ Read it here pubs.rsc.org/en/Jour...
#RSCChemBio
We are also grateful for funding from the NIH, NSF, and the Hartwell Innovation Fund - Swim Across America.
Congrats team!!
It was especially meaningful to work with long-time friends and colleagues. Many thanks to @sauravk05.bsky.social, Jiewei Jiang, @miadonaldpaladino.bsky.social, Joy Chen, Andrea Gutierrez, @afederation.bsky.social, Frank Szuzlewsky, Eric Holland, and @fleurmferguson.bsky.social for the hard work.
Importantly, our lead degrader shows improved specificity over existing molecules, and our biological studies highlight where degraders can offer advantages in TRK fusion-driven cancers.
Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
When broken strands of DNA get repaired improperly, they can stitch together in new “Frankengene” fusions that can cause cancer. Fred Hutch researchers are working to better understand how a fusion called ZFTA-RELA drives rare brain tumors in children. https://bit.ly/4bc8WgG
Here is our updated database of grants for early careers researchers in all fields.
It goes way beyond traditional NIH and NSF funding opportunities. We list 428 types of grants.
Download it here: research.jhu.edu/rdt/funding-...
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Are you an undergrad looking for a summer internship? Application season is underway! Check out these internship opportunities at Fred Hutch.
Apply now: linktr.ee/fredhutch
#datascience #statistics #labexperience
So many phenomenal pumpkins at this year’s carving contest!
Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!
When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti...
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!!
www.nature.com/articles/s41...
The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.
The cover picture depicts a firefly (BSJ-04-146) luring a moth (FAK) to the carnivorous plant (proteasome) and was designed by DrawImpacts.
We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋
👩🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt
🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
Postdoc positions available! Please re-post!
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org
Plug: @sauravk05.bsky.social is hitting the faculty job market, aiming to launch the Kumar lab in 2026. He’s truly exceptional and is building a cutting-edge induced proximity research program. Reach out!
This study was a fantastic collaboration with @fleurmferguson.bsky.social, @afederation.bsky.social, Andrea Gutierrez, Mia Donald-Paladino, Joy Chen, Frank Szuzlewsky, and Eric Holland. We are all grateful for funding from the NIH, NSF, and the Hartwell Innovation Fund - Swim Across America.
🚨 New preprint!
Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
Friday Afternoon Seminar (FAS), this Friday 5/16 at 4pm in Pelton. Rina Hirano, Tsukiyama Lab Elucidating 3D chromatin structure and its regulatory mechanism of rDNA in quiescence Christina Kuismi, Nabet Lab Targeted degradation of non-receptor tyrosine kinases PYK2 and FAK
Two great talks lined up for the final Friday Afternoon Seminars of the season!
For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.
