Super Meat Boy 3D is the best possible execution of a fundamentally bad idea Super Meat Boy 3D does about as good of a job as possible translating the precision platformer to the imprecision of a 3D platformer.

A 3D Super Meat Boy game is a pretty bad idea, but Super Meat Boy 3D pulls it off about as well as possible.

This is figure 1, which shows immune cellular dynamics through the lifespan differ between male and female donors.

An analysis in Nature Aging identifies sex-specific changes in inflammation, autoimmunity and disease risk over the adult lifespan, with more widespread age-related immune remodeling in females. go.nature.com/4mwYVyJ #medsky 🧪

PrismML released Ternary Bonsai: 1.58 bit LLM (open-weight)

Using ternary weights {-1, 0, +1}, they built a family of models that are 9x smaller than their 16-bit counterparts while outperforming most models in their respective parameter classes on standard benchmarks.

The authors included RRIDs in their in bioRxiv paper! Thanks for making your methods matter! #methodsmatter #RRID #OpenScience

Dequantizing Short-Path Quantum Algorithms The short-path quantum algorithm introduced by Hastings (Quantum 2018, 2019) is a variant of adiabatic quantum algorithms that enables an easier worst-case analysis by avoiding the need to control the...

"On the positive side, our results provide a new ``quantum-inspired'' approach to designing classical algorithms for important classes of constraint satisfaction problems."
arxiv.org/abs/2604.12131

Positive to whom?

Why bother with recommendation letters when you get a like from Peter Shor?

With max thinking Opus 4.7 is quite impressive, with a real sense of style

In two prompts: "implement the Tower of Babel, in 3D, in as sophisticated and visually interesting a way as possible. It should be interactive" and then "make it better."

Play: tower-of-babel-1776392618.netlify.app

How the AI oligarchy devoured America How the AI oligarchy devoured America.

Two years ago, we devoted an entire issue to the rise of a new American oligarchy. Since then, this system has only become more entrenched, ever concentrated around a crew of tech titans going all in on AI.

Our newest cover story investigates these new AI overlords and their consolidation of power.

@biorxivpreprint.bsky.social Simulated spaceflight disrupts the immune-gut-brain axis and drives sex-dependent neuroinflammation, axonal injury, and behavioral deficits
www.biorxiv.org/content/10.6...

China Lifts Green Push With Plan to Double Clean Energy by 2035 China will seek to double its supply of non-fossil fuel energy by 2035, in a plan that analysts see as a boost to Beijing’s green targets.

If you are worried that China is beating us, then take a look at this. China is investing heavily in renewable energy. The USA is fighting all forms of green energy.

Reducing dependence on fossil fuels, and diversifying our energy sources could help us get ahead.

It could prevent wars over oil.

Synthetic routes to advancing perovskite solar cells through interface design - Nature Synthesis Interface engineering is promising for advancing perovskite solar cell (PSC) performance and longevity. This Review highlights three emerging strategies for interfacial optimization in PSCs: multifunctional molecular passivation, heterostructures and self-assembled monolayers. The authors discuss relevant materials, assess their limitations and outline challenges and prospective directions for future research.

Now online:

Review article by Bin Chen, Mercouri G. Kanatzidis, Edward H. Sargent & co-workers

Synthetic routes to advancing perovskite solar cells through interface design

www.nature.com/articles/s44... ($)
#Chemsky

Artisanal Academia: changing the titles in the bibliography from title case to lower case letter by letter.

Sigenergy Marks a Significant Milestone With Successful HKEX Listing Sigenergy Technology Co., Ltd. has officially listed on the Hong Kong Stock Exchange, a pivotal achievement backed by global investors.

Sigenergy Marks a Significant Milestone With Successful HKEX Listing #AI_Solutions #Hong_Kong #HKEX #Sigenergy

736 Days

Read the Behind the Paper post from @rhodamine110.bsky.social here:

communities.springernature.com/posts/736-da...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Spontaneous blinking dyes in the far-red range facility single-molecule localization microscopy. @rhodamine110.bsky.social

www.nature.com/articles/s41...

Person functionally cured of HIV after bone marrow transplant from sibling A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to. spklr.io/63324EJmf0

Zara owner Inditex reports unauthorised access to transaction databases Zara owner Inditex said it had ​identified unauthorised access ‌to databases hosted by a third party containing ​information on transactions ​with customers.

Zara owner Inditex reports unauthorised access to transaction databases reut.rs/4mAmiHy

Tesla’s AI Chip Surge Lifts China’s EV Supply Chain

The market's reaction underscores how China's deep integration into global tech supply chains means domestic fortunes are increasingly tied to the AI and automation roadmaps of Western giants. A significant announcement from Tesla sent ripples…

On the point last sentence of the discussion:
"Still, for the specific case of B. subtilis growing on agar plates, we have provided a resolution for the sorites paradox; so how many bacteria make a swarm? Roughly 3,500."

Wow - Faraday meets Jacob & Monod!

Laparoscopic vs Open Adhesiolysis for Small Bowel Obstruction This prespecified analysis of the Laparoscopic vs Open Adhesiolysis for Adhesive Small Bowel Obstruction (LASSO) randomized clinical trial investigates if laparoscopic surgery for adhesive small bowel obstruction decreases small bowel obstruction recurrence rate or incidence of incisional hernias...

Laparoscopic adhesiolysis for #SmallBowelObstruction was not superior to open surgery for long-term recurrence, incisional hernia incidence, or quality of life at 5-year follow-up, confirming both as viable options. ja.ma/41PIzYg

Anisotropic lattice distortion makes ultrastrong martensitic steel ductile - Nature Materials The brittleness of as-quenched carbon martensitic steel is overcome by introducing severe lattice distortion through the addition of high concentrations of substitutional solutes and carbon. This latt...

Anisotropic lattice distortion makes ultrastrong martensitic steel ductile

go.nature.com/4mAqBmc

#preprint by postdoc Billy Haws reveals the determinants of how UBQLN2 forms puncta under heat stress conditions - using both in vitro and in cell experiments, turns out the substrate-binding / chaperone-binding STI1-I and STI1-II domains are the driving forces! www.biorxiv.org/content/10.6...

China’s battery champion pushes deeper into mining CATL puts $4.4bn into new subsidiary to strengthen supply chain self-sufficiency

China’s battery champion pushes deeper into mining ft.trib.al/f1URVLi

Mechanisms of Introspective Awareness Recent work has shown that LLMs can sometimes detect when steering vectors are injected into their residual stream and identify the injected concept -- a phenomenon termed "introspective awareness." W...

New model introspection research! They find evidence that “introspective awareness” emerges in posttraining, in particular DPO

arxiv.org/abs/2603.21396

New work from Gen He Lab at Ocean University of China 🐟🇨🇳

Phage-assisted evolution of allosteric protein switches - Nature Communications Allostery enables proteins to respond to signals but remains difficult to engineer. Here, Southern et al. developed a phage-assisted evolution framework for allosteric protein switches yielding high-p...

www.nature.com/articles/s41...

#phage #phagesky #microsky

Single-cell proteomics by mass spectrometry: Technological overview and recent progress YouTube video by Nikolai Slavov

Single-cell proteomics by mass spectrometry: Technological overview and recent progress

From uncertain possibility to robust and rapidly advancing technologies:

1/2
youtu.be/tibkXV6NblI?...

Judging from the abstracts submitted to the single-cell proteomics conference, SCP2026 is shaping to be an exceptional meeting.

A convergence of new technologies, deep questions, and inventive experimental designs is poised to unlock answers to long standing puzzles.

Abstract deadline: May 1st

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution go.nature.com/3GfqrzL
rdcu.be/faNLM