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Posts by Sibelle Vilaça

DNAharvester's workflow.

DNAharvester's workflow.

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We present DNAharvester 🎉🦴🚜🧬

A pipeline to process highly degraded ancient DNA data that integrates metagenomic filtering, competitive mapping, multiple alignment strategies, reference bias evaluation and much more.

GitHub: github.com/NBISweden/DN...

Preprint: www.biorxiv.org/content/10.6...

5 hours ago 26 15 0 1
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Can you believe that until now there were more genomes sequenced for the woolly mammoth than for living African elephants?

Today, we bring you the first genomic, continent-scale analyses of 232 high-quality genomes of both species, the savanna and forest elephant.

www.nature.com/articles/s41...

5 days ago 144 49 5 2
Heatmaps of climate variables in southwestern United States

Heatmaps of climate variables in southwestern United States

The endangered Pacific pocket mouse

The endangered Pacific pocket mouse

Climate change is a huge challenge for endangered species because genetic variation needed to adapt is often lacking.

Our new study in Science Advances highlights the potential for conservation breeding and reintroduction to boost resilience to climate change. @science.org

doi.org/10.1126/scia...

3 days ago 20 8 1 0
Decision tree for the selection of the most suitable materials for passive sampling based on different matrices, targets and study conditions.

Decision tree for the selection of the most suitable materials for passive sampling based on different matrices, targets and study conditions.

📖Published📖

Passive environmental DNA sampling: A review of current practices, limitations and future directions for biodiversity monitoring 🧬

buff.ly/fB6NKeH

1 week ago 4 2 0 0
Figure 1 from the article, a summary of the IUCN Red List criteria for assessing species into one of the threatened categories: Vulnerable (marked in yellow), Endangered (marked in orange), and Critically Endangered (marked in red). The criteria are demarcated into five categories, with further subcategorization on the basis of each criterion: 

"(A) Population size reduction. Population reduction (measured over the longer of 10 years or 3 generations based on any of A1 to A4)

(B) Geographic range in the form of either B1 (extent of occurrence) AND/OR B2 (area of occupancy)

(C) Small population size and decline

(D) Very small or restricted population

(E) Quantitative Analysis"

Figure text below:
"Figure 1. The IUCN Red List criteria summary sheet. This document, provided by the IUCN, summarizes the five criteria
(A–E) and the associated thresholds for assigning species to one of the ‘threatened’ risk categories: Vulnerable (VU), Endangered (EN), or Critically Endangered (CE). The full details for applying the criteria or assigning species to other threat classes can be found in the Guidelines for Using the IUCN Red List Categories and Criteria (IUCN 2024)
. Use of this summary sheet requires a full understanding of the IUCN Red List Categories and Criteria [11] and the Guidelines for Using
the IUCN Red List Categories and Criteria
. Please refer to both documents for explanations of terms and concepts used here."

Figure 1 from the article, a summary of the IUCN Red List criteria for assessing species into one of the threatened categories: Vulnerable (marked in yellow), Endangered (marked in orange), and Critically Endangered (marked in red). The criteria are demarcated into five categories, with further subcategorization on the basis of each criterion: "(A) Population size reduction. Population reduction (measured over the longer of 10 years or 3 generations based on any of A1 to A4) (B) Geographic range in the form of either B1 (extent of occurrence) AND/OR B2 (area of occupancy) (C) Small population size and decline (D) Very small or restricted population (E) Quantitative Analysis" Figure text below: "Figure 1. The IUCN Red List criteria summary sheet. This document, provided by the IUCN, summarizes the five criteria (A–E) and the associated thresholds for assigning species to one of the ‘threatened’ risk categories: Vulnerable (VU), Endangered (EN), or Critically Endangered (CE). The full details for applying the criteria or assigning species to other threat classes can be found in the Guidelines for Using the IUCN Red List Categories and Criteria (IUCN 2024) . Use of this summary sheet requires a full understanding of the IUCN Red List Categories and Criteria [11] and the Guidelines for Using the IUCN Red List Categories and Criteria . Please refer to both documents for explanations of terms and concepts used here."

A big focus of the article is on the groundbreaking work of extending the IUCN Red List Criteria to assess parasite taxa while considering their unique ecological conditions, such as their reliance on one or more host species and their possible limited distribution compared to hosts.

2 weeks ago 2 2 1 0
A cover to the March 2026 edition of Trends in Parasitology, showing a yellow-brown snail infected with bright green Leucochloridium worms in its eyestalks, perched on the leaf of a plant. The background is black and speckled with droplets of rain or mist.
"Trends in Parasitology
A Cell Press Journal
Parasite coloration
Volume 42 | Number 3 | March 2026 | ISSN 1471–4922"

A cover to the March 2026 edition of Trends in Parasitology, showing a yellow-brown snail infected with bright green Leucochloridium worms in its eyestalks, perched on the leaf of a plant. The background is black and speckled with droplets of rain or mist. "Trends in Parasitology A Cell Press Journal Parasite coloration Volume 42 | Number 3 | March 2026 | ISSN 1471–4922"

A screenshot of the header of the article as it appears on the Science Direct website.
"Opinion
Parasite conservation now: turning knowledge into action
Skylar R. Hopkins, Chelsea L. Wood
https://doi.org/10.1016/j.pt.2026.03.009"

A screenshot of the header of the article as it appears on the Science Direct website. "Opinion Parasite conservation now: turning knowledge into action Skylar R. Hopkins, Chelsea L. Wood https://doi.org/10.1016/j.pt.2026.03.009"

The Parasite Specialist Group has published a new paper on assessing and conserving wild parasite species! The first link below is a DOI, while the second link will allow you to view and download the whole paper until May 23rd.
doi.org/10.1016/j.pt...
authors.elsevier.com/a/1mtNP5Eb1x...

2 weeks ago 8 4 1 0
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New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...

2 weeks ago 161 66 8 7
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De Novo Chromosome-Level Assembly of the Endangered Pilocarpus Microphyllus Highlights Genomic Resources for Conservation and Sustainable Pilocarpine Extraction Abstract. Pilocarpus microphyllus (jaborandi) is an endangered plant species with significant bioeconomic relevance, as it is the main known source of pilo

Sobreiro, @sibellevilaca.bsky.social A. Vidal et al. present a chromosome-level genome assembly for the jaborandi, an endangered tropical American plant species with significant bioeconomic relevance.

🔗 doi.org/10.1093/gbe/...

#genome #evolution #PlantSky

3 weeks ago 3 1 0 0
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Hello beautiful people, remember to send your abstracts before April 15th.
We are looking forward seeing you all in Peru.

4 weeks ago 2 3 0 0
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In the High-level Segment at #CMSCOP15, Marina Silva, Minister of the Environment, Brazil, reiterated Brazil's commitment to working with all countries to conserve migratory species & their habitats, & called for making COP15 “a resounding defence of multilateralism.” #ConnectingNature @cms.int

4 weeks ago 5 5 0 0
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Ne Does Not Provide Sufficient Information on Allelic Variation: Suggestions to Fill the Gap Conservation success depends on translating theory into practical guidance and tools that are relevant and useful for non-scientists. While the complexity of population genetics has challenged the us...

Ne Does Not Provide Sufficient Information on Allelic Variation: Suggestions to Fill the Gap
onlinelibrary.wiley.com/doi/10.1111/...

4 weeks ago 9 7 0 0
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Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 t...

"This observation supports the error hypothesis and suggests that metazoan transcript diversity is largely deleterious." Love this since it matches my priors :-) dx.plos.org/10.1371/jour...

1 month ago 12 5 0 1

#consgen

1 month ago 6 1 0 0
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🐳🧬8 years in the making! 🐳🧬

Our new paper in Cell explores how bowhead whales responded to past climate change - and how commercial whaling reshaped their future.

Check it out here: doi.org/10.1016/j.ce...

#aDNA #PopGen

1 month ago 29 9 1 0
Bugs in a box-an analogy
We can make a physical analogy (if a somewhat fanciful one) by considering a box containing hyperactive, indiscriminate, voracious, and insatiable bugs. We put k bugs into the box. They run about without paying any attention to where they are going. Occasionally two bugs collide. When they do, one instantly eats the other.
Being insatiable, it then resumes running as quickly as before. It is obvious what will happen. The number of bugs in the box gradually falls from k to k - 1, to k-2, as the bugs coalesce, until finally only one bug is left.
The analogy is actually fairly precise. The number of pairs of bugs that can collide is k(k - 1) /2. If there are 2N "places" in the box that can be occupied, the probability of a collision will be proportional to k(k - 1)/4N. The size of the population corresponds to the size of the box. A box with twice as many "places" will slow the coalescence process down by a factor of two. So a simpleminded physical analysis of the bugs-in-a-box process will have the Kingman coalescent distribution as the probability distribution of its outcomes.

Bugs in a box-an analogy We can make a physical analogy (if a somewhat fanciful one) by considering a box containing hyperactive, indiscriminate, voracious, and insatiable bugs. We put k bugs into the box. They run about without paying any attention to where they are going. Occasionally two bugs collide. When they do, one instantly eats the other. Being insatiable, it then resumes running as quickly as before. It is obvious what will happen. The number of bugs in the box gradually falls from k to k - 1, to k-2, as the bugs coalesce, until finally only one bug is left. The analogy is actually fairly precise. The number of pairs of bugs that can collide is k(k - 1) /2. If there are 2N "places" in the box that can be occupied, the probability of a collision will be proportional to k(k - 1)/4N. The size of the population corresponds to the size of the box. A box with twice as many "places" will slow the coalescence process down by a factor of two. So a simpleminded physical analysis of the bugs-in-a-box process will have the Kingman coalescent distribution as the probability distribution of its outcomes.

Thought I would share this famous analogy from Felsentein’s book I just re-stumbled on. Just in case you’re bug in a box and missed it 😜

1 month ago 15 8 0 0

Genomic estimates of inbreeding with runs of homozygosity often outperform pedigree-based F, even from long-term datasets. They integrate occasional gene flow and are less sensitive to underlying pedigree assumptions.
Congrats @marcofesta.bsky.social and co!
#consgen

1 month ago 15 5 1 0
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A widespread gap in U.S. Endangered Species Act implementation: Risk of genetic erosion within populations
doi.org/10.32942/X2K...

1 month ago 4 3 0 2
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7th European Conservation Genetics meeting THEMES | KEYNOTE SPEAKERS | PRELIMINARY PROGRAM |

interested in Conservation Genetics ? #consgen
Then this is THE place to go in 2026 - August in Antwerp
www.zooscience.be/en/7th-europ...

1 month ago 5 4 0 0
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Did you know that Evolution Letters now publishes reviews?! Our inaugural one is fantastic! Deep learning is opening new doors for evolutionary genomics, especially for nonmodel organisms with sparse or uncertain genomic data. doi.org/10.1093/evle...

1 month ago 30 18 0 1

Check out Endemixit's latest paper! The 🦎 Aeolian wall lizard 🦎has the lowest genome-wide heterozygosity observed in wild eukaryotes (one polymorphic site every 300 kb!), but comparable realized genetic load to a large population!

1 month ago 2 1 0 0
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📣 If you are interested in processes, #biodiversity science, policy & implementation related to the Convention on Biological Diversity (UN CBD) - join CO-OP4CBD’s dedicated UN CBD expert database!

📝 Register here: coop4cbd-expert-database.limesurvey.net/236295?lang=...

#Science4Biodiversity

1 month ago 2 1 0 0

Thank you, Anil for this excellent summary of the two @pnas.org papers on #biodiversity measurement and monitoring that came out this week. I love your rallying call to the computer science community to help build the federated system we need. This is firmly in the realm of the doable.

1 month ago 10 3 0 0
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Pangenomes, really?

Most early “pangenomes” = oligogenomes (oligo, Gr., few).

More recent “pangenomes” generally = poligenomes (polis, Gr., many).

True pangenomes (pas, Gr., every/all) would be rare indeed.

🙏🏼 @zbao.bsky.social for pointing out his review.

www.nature.com/articles/s41...

1 month ago 36 13 3 0
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Conserving Genetic and Genomic Diversity in Accordance with the Global Biodiversity Framework Adopted in December 2022, the Kunming–Montreal Global Biodiversity Framework (KMGBF) under the Convention on Biological Diversity outlines a visionary road map guiding humanity's relationship wit...

2026 Annual Review of Animal Biosciences now online! Most read article - Conserving Genetic and Genomic Diversity in Accordance with the Global Biodiversity Framework arevie.ws/3MLGitv
@jess-dasilva.bsky.social @lauradbertola.bsky.social @testeeves.bsky.social @sibellevilaca.bsky.social

1 month ago 6 2 0 0
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Professorship in population genetics in the field of evolutionary anthropology and medicine (W2) Faculties & Facilities

Leipzig U and the MPI for Evolutionary Anthropology (MPI-EVA) have an open faculty position (W2) in evolutionary population genetics! This position is tenured and comes with generous core funding. We are eager to welcome a new colleague! Deadline March 11.
www.uni-leipzig.de/en/newsdetai...

1 month ago 60 98 0 0
PearTree — Phylogenetic Tree Viewer

So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the “Example...” button for immediate candy and then click every button you can find).

1 month ago 166 101 5 4
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The deadline for applying to be an Associate Editor has been extended to the 8th March!

MEE are looking for expertise across a range of topics, including stable isotopes, ecophysiology, mark-recapture methods and modelling, and more!

Find out more and apply here 👇
buff.ly/MzIXj6U

1 month ago 6 5 0 3
Comparison of read mappings at HG002 chr4:40,294,825-40,295,700, showing conventional (pbmm2) read mappings (above) and portello mappings (below). The same set of unaligned input reads were input into each mapping process.

Comparison of read mappings at HG002 chr4:40,294,825-40,295,700, showing conventional (pbmm2) read mappings (above) and portello mappings (below). The same set of unaligned input reads were input into each mapping process.

What if you could improve small variant accuracy, CNV inference, and interpretability of your HiFi WGS data by taking a different approach to read mapping? Our new preprint describes portello, a method which demonstrates the potential for such improvements. (1/5)

2 months ago 25 11 1 1
Photo of nesting sea turtle on a beach with the title of the special superimposed on it.

Photo of nesting sea turtle on a beach with the title of the special superimposed on it.

🐢🦤🧪 ESR Special #26. Initiated at the end of the 20th century, many #MarineTurtle monitoring programs have been ongoing for two or more decades and provide valuable insights into population dynamics and conservation. Contribute now! bit.ly/esr_special26
@brendangodley.bsky.social

2 months ago 2 2 0 0

This recently-accepted study highlights the critical need to incorporate genomic erosion—the loss of genetic diversity, accumulation of harmful mutations, maladaptation, and introgression—into conservation assessments.
1/3

2 months ago 6 4 1 2