Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the two-cell blastomeres differ reciprocally from the start Abstract. Recent advances in embryology have shown that the sister blastomeres of two-cell mouse and human embryos differ reciprocally in potency. An open

🧐 For a long time, we believed that the first #2cells of the mammalian #embryo were identical, both #totipotent.
Recent advances have shown that this is not entirely accurate.

Here, Nolte et al. explain the reasons behind this event and suggest a new model 🔗
academic.oup.com/molehr/artic...