A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...

☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp

📢 New @cp-cellstemcell.bsky.social study!

Investigators showed that methyltransferase-like 3 deficiency reverts naive hESCs to a #totipotent-like state with reactivation and chromatin resetting of 8C-associated genes, eRNAs, and long terminal repeats.

https://bit.ly/4ns8ZaY

Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the two-cell blastomeres differ reciprocally from the start Abstract. Recent advances in embryology have shown that the sister blastomeres of two-cell mouse and human embryos differ reciprocally in potency. An open

🧐 For a long time, we believed that the first #2cells of the mammalian #embryo were identical, both #totipotent.
Recent advances have shown that this is not entirely accurate.

Here, Nolte et al. explain the reasons behind this event and suggest a new model 🔗
academic.oup.com/molehr/artic...