ABT-737 | Bcl-2 Family Inhibitor/BH3 Mimetic | MedChemExpress ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and…

🔸Targeting this pathway or applying senolytic strategies significantly reduces tumor burden in preclinical models

🌟ABT-737, a widely used #BH3 mimetic was cited in this paper
www.medchemexpress.com/abt-737.html
🔗Read the full paper: www.nature.com/articles/s43...
#Bcl2 #CellularSenescence #ABT737