Human #APOBEC3B (A3B) is a single-stranded DNA cytidine deaminase and innate restriction factor predicted to restrict #DNAviruses. Yet mice expressing human A3B showed no decrease in murine papillomavirus replication or disease, in primary keratinocytes or in vivo. 🔗 bit.ly/4bc4374

Dr Pan Jia Wern representing #Malaysian Soc for #Biochemistry & #Molecular #Biology talks on #BreastCancer / role of parity, microbiome, & germline variants/ #APOBEC3B deletion has increased RR to anti-PD-1 #WIC2025 #SITC2025

Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence - Mobile DNA Long Interspersed Nuclear Elements-1 (LINE-1 or L1) make up approximately 21% of the human genome, with some L1 loci containing intact open reading frames (ORFs) that facilitate retrotransposition. Be...

New paper out!
We show that APOBEC3B, a key repressor of retrotransposons, is downregulated in senescent cells — unleashing LINE-1 activity and fueling genomic instability and aging.
🔗 doi.org/10.1186/s13100-025-00378-5
#Retrotransposons #APOBEC3B #Senescence #Aging