⏪ G&D RECAP ⏪

🗓️ February 2025
RESEARCH PAPER: LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells
By Ataei et al. and Miguel Ramalho-Santos
➡️ https://genesdev.cshlp.org/content/39/3-4/280.full

#retrotransposons #genome #chromosome

Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence - Mobile DNA Long Interspersed Nuclear Elements-1 (LINE-1 or L1) make up approximately 21% of the human genome, with some L1 loci containing intact open reading frames (ORFs) that facilitate retrotransposition. Be...

New paper out!
We show that APOBEC3B, a key repressor of retrotransposons, is downregulated in senescent cells — unleashing LINE-1 activity and fueling genomic instability and aging.
🔗 doi.org/10.1186/s13100-025-00378-5
#Retrotransposons #APOBEC3B #Senescence #Aging

DNA methylation at #retrotransposons protects the #germline by preventing NRF1-mediated #activation.

-> www.embopress.org/doi/full/10....

If you are at #AAIC25 and want to see new, unpublished data on #tau, #retrotransposons and circular DNA, check out poster #847 by Morgan Lambert @BrownUniversity from 3:30-4:15 today!

Now online!
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:

5/ Curious to hear why SINE transcription is specifically affected?
Check out our companion preprint by @jakobschnabl.bsky.social , Fabio, and @xxxmichixxx.bsky.social :
📘 bsky.app/profile/jako...
📄 www.biorxiv.org/content/10.1...
#RNApolIII #TFIIIB #Transcription #Retrotransposons

5/ Curious to hear why SINE transcription is specifically affected?
Check out our companion preprint by @jakobschnabl.bsky.social , Fabio, and Michi @xxxmichixxx.bsky.social :
📘 bsky.app/profile/jako...
📄 www.biorxiv.org/content/10.1...
#RNApolIII #TFIIIB #Transcription #Retrotransposons

Featured today by @msklibrary.bsky.social
Double trouble: two retrotransposons triggered a cascade of invasions in Drosophila species within the last 50 years

#GenomicEvolution #Retrotransposons #DrosophilaGenetics #MolecularBiology #GeneticInvasion #TransposableElement

dx.doi.org/10.1038/s414...

MSN

'Jumping gene' caught in the act: Advanced imaging provides new insights into retrotransposons www.msn.com/en-us/news/t...
"Now, for the first time, a retrotransposon has been caught in action inside a cell"
#aging #retrotransposons #cryo-ET
Science/progress marches on - in spite of it all.

'Jumping gene' caught in the act: Advanced imaging provides new insights into retrotransposons An arms race is unfolding in our cells: Transposons, also known as jumping genes or mobile genetic elements as they can replicate and reinsert themselves in the genome, threaten the cell's genome inte...

' #Jumping_gene' caught in the act: Advanced #imaging provides new insights into #retrotransposons.

#cryo-electron_tomography

phys.org/news/2025-03...

Transposable element 5mC methylation state of blood cells predicts age and disease - Nature Aging Transposable elements activate during aging with negative consequences. Morandini et al. show that transposons show rapid loss of methylation in peripheral blood mononuclear cells during aging and tha...

Transposable element 5mC methylation state of blood cells predict age and disease #aging #clocks #5mC #cancer #retrotransposons #THE1A #THE1C #LINEs #SINEs #LTR
www.nature.com/articles/s43...

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration ERV suppression is an essential pathway to protect adult stem cells in somatic regenerative tissues. Stem cell activity-coupled ERV silencing enables lineage progression during adult tissue regeneration.

Ever since hearing about #retrotransposons these elements fascinate me. Here a new study on the role of jumping genes in #aging.

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration | @cellcellpress.bsky.social

www.cell.com/cell/abstrac...

Original post on scicomm.xyz

Happy to spread the word about our new paper in BioData Mining, mostly based on the work of my former student Jakub Horváth. We trained 3 different ML models to detect/classify long terminal repeats (LTR) from plant #retrotransposons, then looked at features that influenced their predictive […]

+ This adaptability resembles a conscious-like adjustment to systemic needs.
So, is it possible at all to say that each stem cell carries the knowledge and will power to perform these activities themselves?
#Retrotransposons #science

Insight into #centromere formation, suggesting crucial roles for #gypsy #retrotransposons moving into #satelliteDNA -dominated neocentromeres

Looking forward to have a more detailed look 🔍🧬

a person is holding a crocheted toy with googly eyes and red arms . ALT: a person is holding a crocheted toy with googly eyes and red arms .

3/ Arc genes evolved from retrotransposons, forming virus-like capsids that help neurons share RNAs and proteins — an unusual and fascinating way for cells to communicate in nervous systems. 🦠🧠📡 #retrotransposons #weirdgenes

Vera Gorbunova at ARDD2023: Transcriptomic and proteomic signatures of longevity
youtu.be/DjYHihUfHq8?...
I ❤️ Dr Gorbunova
I ❤️ fucoidan

#LINE1 #retrotransposons #SIRT6 #fucoidan #aging #inflammation #NaturalProducts #FunctionalFoods

Submit a paper on #transposons #retrotransposons in Frontiers!
#mobileDNA

frontiersin.org/research-topic…