Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate.
It is an honour to have contributed to this 20y struggle ⛰️.
Nanopore duplex sequencing reveals patterns of asymmetric states of 5hmC and 5mC in the medaka brain genome. #AsymetricMethylation #5hmC #5mC #MedakaGenome #Nanopore #LongRead #Sequencing @biorxiv-genomic.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...
Something for #5mC aficionados in this work: I always wondered what ctenophores were using their methylation for, as they don't have "gene body methylation" as most other invertebrates. It seems that methylation is found around TE-rich "promoter" regions that loop to distal enhancers. 1/2
Transposable element 5mC methylation state of blood cells predict age and disease #aging #clocks #5mC #cancer #retrotransposons #THE1A #THE1C #LINEs #SINEs #LTR
www.nature.com/articles/s43...
Needless to say that I’m thrilled to see this happening and -of course- get my hands on this data when the time comes 👩🏼💻 #Epigenetics #DNAmethylation #5mC #5hmC #Strokegenomics #Strokeepigenomics
