Illustration depicting the treatment and research findings on Teplizumab therapy in two individuals with Stage 2 Type 1 Diabetes associated with Autoimmune Polyendocrine Syndrome Type 1 (APS-1). The image shows molecular interactions, treatment action, and improved glucose measures, alongside effects on immune cells and thymus size. Notable elements include AIRE mutation, specific genes — GAD, IA-2, ZNT8A, and changes in CD4+ and CD8+ cell counts in the peripheral blood.
Two individuals with distinct, APS-1 associated mutations and stage 2 type 1 diabetes showed improved BG & reverted to earlier stage T1D after teplizumab. More research needed! #T1D #APS1 #Teplizumab
Read here ➡️ doi.org/10.2337/dc25-1444
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