L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes - PubMed Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction. T...

L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes #citrulline #ARG1 #ARG2 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/33414716/

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? #ARG1 #ARG2 #MECFS #LongCovid

bsky.app/profile/rene...

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart Key points Exposure to environmental hypoxia, at high altitude or in a chamber, impairs cardiac energetics and alters mitochondrial function. Inorganic nitrate, a ubiquitous dietary constituent, im.....

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart #ARG1 #ARG2 #MECFS #LongCovid

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Validate User

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? #ARG1 #ARG2 #MECFS #LongCovid

academic.oup.com/cardiovascre...

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs."

"Arginase type 1 ( #ARG1) is a cytosolic enzyme, and arginase type 2 ( #ARG2) is a mitochondrial one."

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase typ...

Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2 #ARG1 #ARG2 #candesartan #metformin #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...