Prof Cecile King finishing her #ARNASydney2025 talk on biomolecular condensates by promoting the upcoming (free) symposium on the topic in November
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Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky
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MD tells us a lot more on drugging microRNAs, cancer RNAs and many more. So many options. Also discusses Chem-CLIP to interrogate molecular recognition events in live cells. And advancement on this is ChemCLIP-Map-Seq, which allows direct identification using NGS.
#ARNASydney2025 #RNASky
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Small molecules can also be used to affect #RNA lifetime, by triggering degradation. Their main target is diseases triggered by intronic RNA repeats that impair splicing. They found multiple ways to do this. For references see pic 👇🏼
#ARNASydney2025 #RNASky
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Once they could identify these interactions, they developed Inforna, which mines secondary structures within target RNAs, and compares them to their database of known RNA motif–small molecule binding partners. Latest Inforna update 👇🏼
pubs.acs.org/doi/10.1021/...
#ARNASydney2025 #RNASky
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To identify targets they developed an #RNA encoded motif library and tested it against a DNA encoded library, allowing them to test > 300 million interactions through FACS sorting.
Full paper:
www.pnas.org/doi/full/10....
#ARNASydney2025 #RNASky
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His lab is aiming to take human RNAs that cause disease, specifically:
- How to target human RNAs with small molecules/chemical proves in scalable and defined ways?
How to find these molecules, how to test for binding, how to assess how/if they are working?
#ARNASydney2025 #RNASky
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We are now listening to our Keynote speaker, Matt Disney, from The Scripps Research Institute 🇺🇸, who due to unforseen circumstances could not join us in-person. Matt's presentation was generously sponsored by the UNSW RNA Institute (@unswrna.bsky.social)
#ARNASydney2025 #RNASky
🧵👇🏼
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Closing the session, we have Alexander Gillis from @scottbscience.bsky.social lab, talking about their latest insights on transcriptional homeostasis. Interestingly, despite triggering a Pol II accumulation in human cells, there is no increase in transcription.
#ARNASydney2025 #RNASky
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Now's the turn of Sebastian Leidel, from the University of Bern 🇩🇪, discussing how m6A mediates mRNA decay. Rapidly degraded mRNAs tend to have more m6A in their CDS, a signal that's generally missed in metagene plota of m6A. Codon choice & mRNA mods tune mRNA decay rates.
#ARNASydney2025 #RNASky
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After some technical issues, we are now hearing from @traudebeilharz.bsky.social, on polyadenylation across the mRNA lifecycle. The shape of the Poly(A) tail is a marker of RNA fate and can be assessed using techniques such as PATTERNseq.
#ARNASydney2025 #RNASky
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Starting the last day of #ARNASydney2025 with the RNA Processing and Modifications session. First, @edueyras.bsky.social, who is developing pipelines to identify #RNA modifications in using @nanoporetech.com
👀 this preprint on the conservation of RNA modifications:
www.biorxiv.org/content/10.1...
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Yesterday, after our 2nd poster session and a stunning sunset seen from the Aerial UTS, we closed the day at our Evening Social at the Old Clare Hotel 🥂
Glad Sydney weather has been cooperating 🌤️
#ARNASydney2025
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We wrap up the non-coding #RNA session with Sayanthooran Saravanabavan telling us about the computational discovery of TDP-43-Responsive Circular RNA:DNA Hybrids (circR-loops) in neuronal cells, particularly in the context of ALS.
#ARNASydney2025 #RNASky
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Now is the turn of @stacedw.bsky.social telling us about a #lncRNA as a therapeutic for ER+ breast cancer. Cannot share more details, but I can say seeing the promise of #lncRNAs starting to bear fruit is very exciting!
#ARNASydney2025 #RNASky
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Now Yuchen Feng @sydney.edu.au, tells us about the pan-cancer #lncRNA MILIP, which interacts with and enables the repression of p53 by c-Myc in cancer cells. MILIP also binds the elongation factor eEF1alpha1, promoting protein synthesis, by enhancing tRNA type II interaction
#ARNASydney2025 #RNASky
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We are now in the non-coding #RNA session at #ARNASydney2025. We heard a fascinating story on other functions of the TERRA #lncRNA, which binds ATRX and gene promoters. It also is more abundant in the aging brain. A great talk by Hsueh-Ping Chu from the National Taiwan University.
#RNASky
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Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠
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I particularly want to highlight the excellent talk by Elizabeth Chen @sydney.edu.au, showcasing a clever construct to dissect LNP formulation immunogenicity and vaccine expression. Clear presentation and detailed answers to questions 👏🏽👏🏽👏🏽
#RNASky #ARNASydney2025
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We had a set of amazing talks in the #RNA in immunity session at #ARNASydney2025. Presentations by Stacey Horner, @drnatsampaio.bsky.social, Elizabeth Chan and Kitty McCaffrey. From viral infections to bacterial toxins, a really great session.
#RNASky
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Key messages from the 2nd session:
Molecular complexes and RNAs are highly dynamic and function in complex and crowded contexts (think EEAO) @nilswalterlab.bsky.social
#RNA Modifications are important, structures are important and heterogeneous
#ARNASydney2025
#RNASky
@unswrna.bsky.social
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Day 2 of #ARNASydney2025 started with the #RNA in disease session, sponsored by RNA Australia, with talks by Sandra Cooper, Glen Reid, Lachlan Jolly & Agin Ravindran. Now focusing on Nucleic Acids Structure, Chemistry & Dynamics with @nilswalterlab.bsky.social, Jacob Munro & Vincent Corbin. #RNASky
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We continued with our first #RNA in plants 🌱 session, hearing from Neena Mitter, Ian Small, Jakub Dolata & Soumitra Patekar telling us about the enormous potential of RNA for bio-pesticides and sequence editing. So much to do in this area!
#ARNASydney2025 @plants4space.bsky.social
#RNASky #AgSky
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Prof Nils Walter from U.Michigan back in Sydney, mentions it's his favourite place!
Opening up the #ARNASydney2025 structure, chemistry and dynamics session.
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Yesterday we had a brilliant start to #ARNASydney2025. We kicked off with the #RNA in neuroscience & RNA tech, AI & Bioinformatics sessions. Speakers included @sergiuppasca.bsky.social, Mike Clark, @sabaaltaf.bsky.social, Nicole Green and several others
#RNASky @unswrna.bsky.social
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The annual meeting of the Australasian RNA association is on for the next 3 days at UTS.
Possibly one of the longest hashtags ever #ARNASydney2025
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Speed dating - Tuesday, September 2nd, after AGM, Informal EMCR Dinner - Monday, September 1st, after welcome reception. Bingo & Exhibitor card challenge - ask at the registration desk!
If you are an EMCR at #ARNASydney2025, join special events by EMCRs for EMCRs!
Meet new colleagues at Speed-dating and join the Informal EMCR Dinner. You can also play some Bingo and win a prize by joining our Exhibitor Card Challenge!
Visit our sponsors to participate. All details 👇
#RNASky
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Career Development Panel for A-RNA - Dr Natalia Sampaio, A/Prof Glen Reid, A/Prof Martin Smith
RNA Commercialisation Workshop, sponsored by BioNTech. Panel: Prof Sue Fletcher, Prof Nils Walter, Dr Noelia Nebot
Only 3 sleeps until #ARNASydney2025!!! Excited to host two special panels:
💼 Career Development Panel - organised by our outstanding A-RNA EMCR team
💊 RNA Commercialisation Workshop - generously sponsored by BioNTech Australia
Register at www.a-rnameeting.org.au
#RNASky @unswrna.bsky.social
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