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“ATP synthase & Ca²⁺ disruption impairs contractility in aging cardiomyocytes”

GCAG 2026
🗓Apr 20–21, 2026 |📍Dubai, UAE

Register: agingcongress.com/edition2//re...

#CardiovascularAging #Mitochondria #ATPSynthase #CalciumSignaling

Angle‑Clamp Technique Boosts Efficiency of Cellular ATP Motors

Angle‑clamp control of an F₁ ATP synthase motor from a thermophilic Bacillus improves efficiency over constant torque, cutting futile dissipation (Physical Review Letters, 2025). Read more: getnews.me/angle-clamp-technique-bo... #atpsynthase #angleclamp

Our ATP Synthase paper model actually turns, just like the real thing! Seeing how protons drive the production of ATP makes concentration gradients & membranes in the mitochondria make sense! Learn more here: bit.ly/2r6UV03

#EduSky #ATPSynthase #ATP #biochemistry #biochem #iteachbio

❄️ #Mitochondrial #ATPsynthase in the glacier ice worm Mesenchytraeus solifugus:
a unique domain in the ATP6 subunit increases #ATPsynthesis

➡️ bit.ly/3DhREAC

More #MitochondrialBiology at
➡️ bit.ly/3IK3UbG

What you can see here is a screenshot of ChimeraX showing the protein databank PDB: 5ARA of an ATP Synthase multi-subunit protein machine used for producing ATP from the flow of Hydrogen ions down the concentration gradient from the high concentration in the inter membrane space into the lower concentration mitochondrial matrix. All subunits except the F) Beta subunits that are used in the mitochondrial membrane are coded for on nuclear chromosomes. The F0 component ATP6,ATP8 are coded for on the mitochondrial circular genome. All others have been relocated into the nuclear genome as it has better error correction, break repair and is less exposed to oxidative damage. The F0 subunit encoding was kept on the mitochondrial genome as it allows the mitochondria to react quicker to changes in energy requirements by being able to maintain local protein production inside the mitochondria. All other subunits' proteins have to have mitochondrial targeting signals to allow them to be transported to the mitochondrial. This allows the mitochondria to quickly shut off ATP synthesis by halting the synthesis of the F0 subunit. Since all components are needed for it to function it can switch off operation by simply removing one crucial subunit.

What you see here in the Chimera-X software package is the 5ARA cattle (Bovine) ATP Synthase obtained by X-Ray crystallography and the proteins to the left and right are predicted protein structures that I created by passing the 22 amino acid sequences to Alphafold3. (11 distinct sequences with some components such as AT5G1 repeating). I basically just threw the FASTA sequences into a JSON file and uploaded it. Alphafold 3 was able to accurately combine the predicted folded proteins into the correct multi subunit enzyme structure. Amazing! Alphafold 3 can be found at https://golgi.sandbox.google.com/

These are the amino acid subunit sequences I uploaded to Alphafold 3 to obtain the multi subunit predicted structure.

One of the most universal protein machines across all domains of life. Here is the ATP Synthase of cattle (PDB: 5ARA). Image on the left shows that all subunits except the F0 Beta subunit (which is found on CHRM) are coded on the nuclear genome.
#PDB #bioinformatics #atpsynthase

Pieniä pyöriviä sähkömoottoreita löytyy myös sinun jokaisesta solustasi tuhansittain

ATP-syntaasi #ATPsynthase www.youtube.com/watch?v=kXpz...