A molecular rendering of the engineered graft of IL-10 with an antibody (GFT-IL10M). Structural analysis of GFT-IL10M using x-ray crystallography at the ALS provided insight into its improved anti-inflammatory properties. The schematic illustrates that the designed biotherapeutic minimized pro-inflammatory signaling observed in wild-type IL-10. (Credit: Michael DiDonato/Novartis Biomedical Research)

Researchers from Novartis Biomedical Research used a #BioMBIB -run beamline at the @als.lbl.gov to confirm the structure of an engineered immune system protein that could open new opportunities to treat inflammatory bowel disease.

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