Kanupriya Pande's group in #BioMBIB has an opening for a postdoctoral fellow to work on the development of computational methods and software for protein structure determination.
Learn more and apply: jobs.lbl.gov/jobs/computa...
A cross-section of the crystal structure for the enzyme Pks13 (the surface colored pink and blue by hydrophobicity) as it interacts with CMX410 (shown as stick-like structure), a new drug candidate for TB.
X-ray diffraction data collected at #BioMBIB beamlines at the @als.lbl.gov revealed the structure of a new compound that targets a key enzyme in the cell membrane of the bacterium responsible for tuberculosis. Led by @tamu.bsky.social & @scripps.edu. @berkeleylab.lbl.gov Read more: go.lbl.gov/TB
A postcard with headshots of the awardees in hexagonal shapes and the Director's Award logo.
Congratulations to the Biosciences Area's 2025 @berkeleylab.lbl.gov Director's Award recipients: Kateryna Zhalnina (Early Career), Jonelle Tamara Basso (Mentorship), Kjiersten Fagnan (Organizational Impact), Graham Fleming (Scientific), and Bruce Cohen (Scientific)!
@jgi.doe.gov #BioEGSB #BioMBIB
Congratulations to the 21 researchers from the Biosciences Area @berkeleylab.lbl.gov who are among @clarivateag.bsky.social's #HighlyCited2025! View the full list: clarivate.com/highly-cited-researchers
@jgi.doe.gov @jbei.lbl.gov @ucberkeleyofficial.bsky.social #BioBSE #BioEGSB #BioMBIB
To advance the fight against antibiotic resistance, a team led by @fraserlab.com developed a compound that could help restore the effectiveness of a class of antibiotics known as streptogramins. They used data collected at @als.lbl.gov & SSRL. #BioMBIB @berkeleylab.lbl.gov
go.lbl.gov/streptogramins
Left: The Protein Society 2025 Fellows logo. Right: Woman with short auburn hair wearing a colorful scarf and black top.
Congratulations to #BioMBIB faculty scientist Susan Marqusee, who was named to The Protein Society's inaugural Fellows class. Susan is a professor of biochemistry, biophysics and structural biology @ucberkeleyofficial.bsky.social and Director of @qb3-berkeley.bsky.social .
We are hiring! Come join #TeamBioSci and help us bring science solutions to the world @berkeleylab.lbl.gov.
Kanupriya Pande's group in #BioMBIB has an opening for a Computational Postdoctoral Fellow (cryo-EM).
lbl.taleo.net/careersection/2/jobdetai...
A nurse shark against a background of clear blue water.
Researchers @scripps.edu used the BCSB macromolecular crystallography beamline 5.0.2 @als.lbl.gov to characterize a protein from a modern shark gene that explains the evolution of the adaptive immune system shared by all vertebrates. #BioMBIB
🦈 go.lbl.gov/bcsb-shark
#BioMBIB faculty scientist Markita Landry's lab @ucberkeleyofficial.bsky.social developed a novel nanosensor for #oxytocin that was recently used in a collaboration with Cal colleague Annaliese Beery's lab to show that the "love hormone" is important for friendships, too. go.lbl.gov/oxytocin
Photo showing three potato plants growing in soil: the ones on the left and right are healthy; the one in the middle is wilted due to the bacterium Ralstonia solanacearum. Credit: Amilcar Sanchez
A team led by scientists @ucdavis.bsky.social, that included Daniil Prigozhin of #BioMBIB, used AI to help plants recognize a wider range of bacterial threats. The approach may lead to new ways to protect crops like tomatoes and potatoes from devastating diseases. go.lbl.gov/plant-immune-upgrade
A card with two illustrated scientists that reads, "We are hiring! Join #TeamBioSci Learn more at go.lbl.gov/bioscijobs."
Join #TeamBioSci & help us bring science solutions to the world at @berkeleylab.lbl.gov!
We are #hiring an Advanced Analysis Manager & Research Associate Principal at @jgi.doe.gov, DevOps Software Engineer at @kbase.us & a computational postdoc for #cryoEM in #BioMBIB.
go.lbl.gov/bioscijobs
A molecular rendering of the engineered graft of IL-10 with an antibody (GFT-IL10M). Structural analysis of GFT-IL10M using x-ray crystallography at the ALS provided insight into its improved anti-inflammatory properties. The schematic illustrates that the designed biotherapeutic minimized pro-inflammatory signaling observed in wild-type IL-10. (Credit: Michael DiDonato/Novartis Biomedical Research)
Researchers from Novartis Biomedical Research used a #BioMBIB -run beamline at the @als.lbl.gov to confirm the structure of an engineered immune system protein that could open new opportunities to treat inflammatory bowel disease.
go.lbl.gov/atg38j
#IBD #AcceleratingScience @berkeleylab.lbl.gov
James Fraser, with graying hair and short beard wearing two black shirts and jeans, in front of a curtain holding the award. He is flanked by a man with very little hair wearing a light blue dress shirt and dress pants and and a woman with shoulder-length blond hair and glasses wearing a black top and predominantly red and orange multi-colored and patterned scarf.
Congrats to #BioMBIB faculty scientist James Fraser! He received the Carl Brändén Award during the #PS39 @proteinsociety.bsky.social meeting for outstanding contributions to #ProteinScience that span research, education & service.
@fraserlab.com @berkeleylab.lbl.gov @ucsfmedicine.bsky.social
A headshot of Graham Fleming, senior faculty scientist in Berkeley Lab's Molecular Biophysics and Integrated Bioimaging Division, and his quote, "Photosystem II doesn't just collect sunlight––it makes incredibly smart decisions about what to do with that energy. We've uncovered how nature balances two goals: getting the most from every photo while also protecting itself from too much light."
Photosystem II produces the air we breathe and protects the plant from too much energy. Graham Fleming & his team have pieced together how energy moves through this complex system. Their work has big implications for #bioenergy and #agriculture.
👉 go.lbl.gov/PSII
#BioMBIB @berkeleylab.lbl.gov
Picture of MBIB senior scientist Vittal Yachandra and his quote from the press release overlaid on a picture from the study, "Femtosecond laser pulses let us study atomic bonds breaking and forming. Now we’re going inside to look at not just the making or breaking of a bond, but what actually is a bond?
A team from @berkeleylab.lbl.gov, @uwmadison.bsky.social, SLAC Nat'l Lab, SACLA, and others, has invented an X-ray laser approach so fast and powerful that it can capture details about quantum-scale phenomena like the movement of electrons.
Read more: go.lbl.gov/attosecond-imaging
#BioMBIB
Congratulations to #BioMBIB Eva Nogales on her election as a Foreign Member of the Fellowship of the @royalsociety.org. She was recognized for her pioneering electron microscopy work and joins the ranks of Einstein, Newton, and Darwin! go.lbl.gov/nogales-royal-society
📷 by @christophermichel.com
Undergraduate laboratory intern Lauren Blake and Banu Sankaran, a research scientist and Collaborative Crystallography program lead, load samples into the dewar at ALS beamline 8.2.2 to collect diffraction data for for 2024 Nobel laureate David Baker. (Credit: Roy Kaltschmidt/Berkeley Lab)
Learn how scientists within our #BioMBIB Division are leveraging the capabilities of @berkeleylab.lbl.gov's @als.lbl.gov to unravel the 3D structure of proteins, aiding cancer therapy development and the nation’s efforts to tackle emerging health threats. 👉 go.lbl.gov/ALSimpact
Renderings of RNA structures used to evaluate the accuracy of the new process. (Credit: Michal Hammel/Berkeley Lab)
#BioMBIB scientists have collaborated with researchers at @hebrewuniversity.bsky.social on an open-source process for uncovering the 3D structures of RNA molecules, unlocking new possibilities for understanding how noncoding RNAs could be harnessed in science and medicine. go.lbl.gov/SCOPER
The crystal structure of a peptidyl carrier protein (green) and its neighboring E domain (gray). The larger cryo-EM structure (yellow) is also shown for context. Finally, the movement of the PCP is highlighted as it moves between the bound state with the E domain and the bound state with the C domain.
Scientists at @ucsandiego.bsky.social brought their work to @berkeleylab.lbl.gov's @als.lbl.gov to learn more about molecular assembly lines. Their results could help scientists design and create new and improved medicines (like antibiotics) using synthetic biology. #BioMBIB go.lbl.gov/NRPS
Work by #BioMBIB 's James Holton and James Fraser – who used the @als.lbl.gov to bridge the gap between prediction and actual structure of an artificial enzyme dreamt up by a chatbot-style #AI – mentioned at timestamp 2:15.
Check it out! 👇
Delayed initiation of hormone therapy for menopausal symptoms was associated with faster accumulation of tau tangles in the brain—a biomarker for #Alzheimer’s disease—in a study led by #MassGeneralBrigham that included #BioMBIB ‘s Suzanne Baker as a collaborator. Read more 👉 go.lbl.gov/HTtau
🎉 Kudos to the researchers and operators of @als-lbnl.bsky.social's 9 structural biology beamlines on depositing 10k macromolecular structures solved by users in the @rcsbpdb.bsky.social to date! From fundamental insights 🧬 to drug discovery 💊 to de novo design 🧩, here’s to the next 10k! #BioMBIB
Check out a new short docu that follows #BioMBIB staff scientist Aaron Brewster and his collaborators from @uconn.bsky.social as they travel to Japan to study the atomic structure of #materials … Crystals! Beamlines! And travel, oh my!
biosciences.lbl.gov/2025/04/09/n...
@berkeleylab.lbl.gov
Congratulations to #BioMBIB faculty scientist, Markita Landry, for being awarded a 2025 Guggenheim fellowship! Learn more about how her fellowship research that will focus on an aspect of the high-altitude Bolivian Altiplano.
biosciences.lbl.gov/2025/04/18/l...
@berkeleylab.lbl.gov
Introducing the nitroplast! 🧪🌱 🎧
"Scientists may use this information in the future to help plants make their own fertilizer from nitrogen in the environment" - Junko Yano, #BioMBIB Division Director at Berkeley Lab
@als-lbnl.bsky.social
@biosci.lbl.gov
@npr.org
#BioMBIB
The NPR Morning Edition recently interviewed Valentina Loconte about how #BioMBIB researchers used the @als-lbnl.bsky.social to help solve a research mystery - how a single-celled algae can fix nitrogen.
Learn more with this 4-minute listen:
www.npr.org/2025/03/13/n...
@berkeleylab.lbl.gov
Science magazine's 2024 Breakthrough of the Year was lenacapavir. Phenix software developed in #BioMBIB was used to determine 3D structures of the HIV capsid protein bound with lenacapavir. (https://pmc.ncbi.nlm.nih.gov/articles/PMC7831379/
https://bsky.app/profile/berkeleylab.lbl.gov
https://bsk…
#BioMBIB affiliate faculty scientist Gary F. Moore was selected by President Biden to receive the PECASE, the highest honor bestowed by the U.S. government on outstanding scientists and engineers early in their careers. Congratulations Gary!
newscenter.lbl.gov/2025/01/16/t...
@berkeleylab.lbl.gov
New #BioMBIB research offers clues to understanding the potential role of unrepaired DNA damage in the progression of #NeurodegenerativeDiseases and could help inform the development of therapies. @berkeleylab.lbl.gov @harvardchanschool.bsky.social
newscenter.lbl.gov/2025/01/13/u...
#Aging
