#AgeingandCancer

Ageing, immune fitness and cancer - Nature Reviews Cancer Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

🥳 First up in #NRCtop10of2025:

#10) Ageing, immune fitness and cancer

#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
#NRCtop10of2025

The evolution of cancer and ageing: a history of constraint - Nature Reviews Cancer In this Perspective, de Magalhães explores the evolutionary relationship between cancer and ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration later on, representing a trade-off that constrains the evolution of longer lifespans.

ICYMI 🚨

In this month's #Focus issue on #AgeingandCancer, de Magalhães explores the evolutionary relationship between cancer & ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration later.

#PERSPECTIVE 📖 👇

ICYMI 🚨

In this month's #Focus issue on #AgeingandCancer, McAllister & colleagues discuss recent insights derived from age-resolved immunoprofiling of the TME and how ageing haematopoiesis affects immune cells and cancer progression.

#REVIEW 📖 👇
https://bit.ly/440R8

ICYMI 🚨

In this month's #Focus issue on #AgeingandCancer, Easwaran & Weeraratna outline how ageing leads to epigenetic alterations in the tissue microenvironment, enhancing clonal expansion of mutations + increasing cancer risk.

#REVIEW 📖 👇
https://bit.ly/4o6dk

Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:

- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing

Check it out 👇
http://bit.ly/4oUyzq

Tissue specificity of ageing in cancer risk prediction - Nature Reviews Cancer Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. In this Comment, LaBarge and Binder explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues.

In our current Focus issue, #AgeingandCancer, LaBarge & Binder explore how tissue-specific ageing biomarkers can enhance cancer risk stratification, and highlight the need for tailored approaches in assessing susceptibility across different tissues.

Cancer treatments accelerate ageing - Nature Reviews Cancer While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.

In our current Focus issue, #AgeingandCancer, Marco Demaria outlines how understanding the underlying molecular mechanisms of cancer treatment induced premature ageing-related conditions is crucial for developing integrated strategies to improve survivor health.