Fighting Back: Unmasking SARS-CoV-2 PLpro's Drug Resistance Hotspots The global battle against SARS-CoV-2, the virus behind COVID-19, continues to evolve. While the pandemic may be winding down, the virus and its capacity to mutate remain a significant challenge to pub...

COVID-19's not done evolving. New research from Wang Lab @Rutgers identifies resistance mutations in SARS-CoV-2’s papain-like protease—E167, Y268, Q269—that weaken PLpro inhibitors like Jun12682 & PF-07957472. go.njmicrobe.org/i8Ff4M #COVID19 #AntiviralResistance #PLpro #Rutgers #SARSCoV2

11/12 MUTATION RACE: "We'll never catch up with Mother Nature. We're never gonna catch up with the virus and how it mutates."

Goal: detect mutations that make virus resistant to antivirals or "more mammalian adaptable" before it's too late.
#MutationRace #AntiviralResistance #Adaptation

7/8 Resistance mutation emerges: some infected poultry carried NA-H275Y, linked to antiviral resistance. Found only in domestic birds, not wild ones, suggesting selective pressure from treatment attempts or different viral evolutionary paths.
#AntiviralResistance #Mutation #SelectivePressure

US study uncovers antiviral resistance in swine-origin influenza, urging enhanced pandemic surveillance Researchers in the US analyzed swine-origin influenza viruses, identifying key mutations that could reduce antiviral drug effectiveness and threaten pandemic preparedness.

US study uncovers antiviral resistance in swine-origin influenza, urging enhanced pandemic surveillance 🐖🦠💉 www.news-medical.net/news/2024100... #pandemicpreparedness #antiviralresistance #swineflu #influenza #virus #publichealth #epidemiology