In adults with moderate to severe #ARDS, inhaled sevoflurane sedation produced fewer ventilator-free days and lower 90-day survival than intravenous propofol, raising safety concerns including acute kidney injury.

🎥 Watch the video and read the full article:

ja.ma/4bNuPlu

Taken together, our results support an underlying landscape of genetic heterogeneity in the spectrum of rare variants influencing #ARDS susceptibility.

Most notable genetic associations were observed for variants in gene clusters enriched in the Toll-like receptor cascades and the Interferon signaling. We also found no overlap between the genetic risk for #ARDS and patient survival.

We show that rare variants with predicted impact in gene function and affecting biologically proximal gene clusters are associated with #ARDS risk among sepsis patients.

Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndrome - Respiratory Research Respiratory Research - Acute respiratory distress syndrome (ARDS) is a complex, heterogeneous, and deadly condition often resulting from pulmonary lesions due to sepsis, among other causes. There...

Here, we identified rare genetic risk factors of sepsis-associated #ARDS using a gene-clustering approach by leveraging a large exome sequencing of the GEN-SEP study and information from biological processes for adapting to patient heterogeneity. link.springer.com/article/10.1...

To date, sequencing-based studies assessing rare genetic variant effects on #ARDS have been conducted with small cohorts or with affected families with immune defects.

It has been shown that common genetic variants (>1% population frequency) in genes involved in cellular adhesion, platelet activation, vascular permeability, and immune-inflammatory processes have a role in #ARDS susceptibility.

Host genetic variation influence responses to infections. Sepsis is a severe response to infection and these patients can develop acute respiratory distress syndrome #ARDS

Alt: aerial view of Chicago skyscrapers covered in cloud, with orange to blue sunset colours Credit: Razvan Sera/Amazing Aerial Agency/Science Photo Library

📊 Round up of The Lancet Respiratory Medicine content presented at #SCCM

🏥 Wonderful to see so many advances presented during the congress, continuing progress in #CriticalCare

#ARDS #SEPSIS #BRONCHIOLITIS @sccmcriticalcare.bsky.social

🚨 Conference Alert: New Article Available Open Access @sccmcriticalcare.bsky.social

📊 Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study

#ARDS #Sepsis #SCCM

🔓 tinyurl.com/mwvtjub3

📰 Linked Comment: tinyurl.com/yy2aps7m

🎥 Don't miss the 𝘀𝗲𝗰𝗼𝗻𝗱 𝗘𝗦𝗜𝗖𝗠–𝗜𝗦𝗖𝗖𝗠 𝗕𝗿𝗶𝗱𝗴𝗲 𝗪𝗲𝗯𝗶𝗻𝗮𝗿 focusing on 𝗔𝗥𝗗𝗦 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗶𝗻𝗷𝘂𝗿𝗲𝗱 𝗹𝘂𝗻𝗴!

💡 Expect a real-life case study, rich clinical insights, and a dynamic expert discussion with our faculty.

🗓️ 𝗧𝗵𝘂𝗿𝘀𝗱𝗮𝘆, 𝟮𝟲 𝗠𝗮𝗿𝗰𝗵, 𝟭𝟲:𝟬𝟬 𝗖𝗘𝗧👉 shorturl.at/yisTe

#ESICM #ISCCM #ARDS #IntensiveCare #ESICMWebinar

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JAMA Network Open presents RCT: Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery. Population: 210 men, 172 women. Intervention: 424 patients randomized, 382 analyzed. Findings show Sivelestat reduced ARDS compared to placebo.

In patients undergoing cardiovascular surgery with cardiopulmonary bypass, postoperative infusion with #Sivelestat significantly reduced the incidence of #ARDS and 90-day mortality compared with placebo.

ja.ma/3NzsK4q

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Pulmonary hemodynamics in #ARDS pts in VV #ECMO
PAH highly prevalent, and early upward trajectories in mPAP predicted mortality
🫁 invasive pulmonary hemodynamic monitoring may provide relevant insights in selected pts at higher risk of RV dysfunction or with early signs of RV failure
🔓 rdcu.be/e7Dof

#ECMO without systemic anticoagulation? Editorial
🔗 bit.ly/4u6yqUd

🩸 Refers to study investigating association between systemic anticoagulation & outcomes in patients with #ARDS receiving VV #ECLS. Authors observed no link between systemic anticoagulation and
short-term survival.
🔗 bit.ly/3P1pkrv

COVID-19 ARDS survivors face lasting disability and high late mortality, researchers report In this single-center ambispective cohort of 283 Polish patients with COVID-19–related ARDS requiring invasive mechanical ventilation, cumulative mortality reached 44.5% at four years after ICU admiss...

😷 Four years after ICU, nearly half of ventilated COVID-19 ARDS patients have died, and survivors still battle fatigue, insomnia, and disability. The long-term toll is stark. www.news-medical.net/news/2026030... #Covid19 #LongCovid #ARDS

VT-109, an EB3 inhibitor, restores endothelial integrity in #ARDS by blocking #CalciumSignaling, reannealing VE-cadherin, and activating #FOXM1; it improves #LungFunction and reduces #inflammation.

#OpenAccess in #STTT: doi.org/10.1038/s413...

ARDS (Acute Respiratory Distress Syndrome): Pathophysiology, Stages, Diagnosis & ICU Management
#ARDS #AcuteRespiratoryDistressSyndrome #CriticalCare #ICU #RespiratoryFailure #MechanicalVentilation #PulmonaryEdema #RefractoryHypoxemia #Sepsis #MedicalEducation

Prone positioning in VV #ECMO?? no net physiological benefit after #ECLS initiation in this animal model 🐖 with severe #ARDS randomized after VV initiation to prone or supine positioning for 48 h, receiving an ultraprotective MV strategy 🫁
Open access #FOAMcc #FOAMecmo
🔓 rdcu.be/e28tP

Prone positioning in VV #ECMO
🐖 8 pigs with severe #ARDS randomized after VV initiation
🫁 PP did not reduce the overall extent/severity of lung injury but shifted distribution of damage, with greater involvement of dependent regions and relative preservation of non-dependent areas.
🔓 rdcu.be/e28tP

Tomorrow we welcome Dr. Angela Meier to Grand Rounds. #MedEd #PCCM #ARDS
@ucsdmedschool.bsky.social

#VT109, a synthetic EB3 inhibitor, shows efficacy in murine #ARDS by restoring endothelial barriers, activating #FOXM1 repair, reducing #inflammation, and improving #LungFunction—emerging as a strong candidate for clinical testing.

#OpenAccess in #STTT: doi.org/10.1038/s413...

🏁 FULLTIME — Ards 0–0 Institute. Championship #ards #institute

🏁 FULLTIME — Ards 0–0 Institute. Championship

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