#ArterialAging

Age-related ⏬SRF/Myocardin & ⏬#YAP/TAZ in human arteries 20 ~79 y/o @GTExPortal

Itga8+ #SmoothMuscleCell SRF KO in young adult🐭
#Aorta within 12~16 wk
👉⏬Contractile force generation
👉⏫Aggrecan
👉⏫YAP/TAZ activity

MYOCD OE➡️⏫MOB1 LATS1/2

#JBC 2025
www.jbc.org/article/S002...

#ExtraCellularMatrix #ArterialAging Sox9

#SmoothMuscleCell Sox9➡️#ExtracellularVesicle (PLOD3)➡️ECM Stiffness➡️SMC #Senescence & likely #ArterialStiffening

Senescent #SmoothMuscleCell, seeded on ECM deposited by Sox9-KD SMCs, can proliferate again!

#CircRes 2024
www.ahajournals.org/doi/abs/10.1...