Super excited to announce The Matrix: Adipose Remodelled 🧬Join us in Nottingham 📍| 7–8 December 2026 🗓️
Register your interest👇
www.biochemistry.org/events-and-t...

#NTU #SHiMR_NTU #NTUResearch #NTUMetabolic #Adipose #AdiposeTissue #conference #organoid #metabolism #OMICS #ExtracellularMatrix

Skin wound healing depends on more than structure alone. 🩸This review explores how matricellular proteins fine-tune #ExtracellularMatrix signalling to coordinate cell migration, proliferation and tissue repair, highlighting their central role in #RegenerativeMedicine. doi.org/10.1002/1873...

Collagen Hybridizing Peptides now available from Ilex Life Sciences! 3Helix appoints Ilex Life Sciences as a worldwide distributor of Collagen Hybridizing Peptides! Ilex Life Sciences LLC and 3Helix, Inc. have entered a distribution agreement to expand global access to...

Ilex Life Sciences LLC and 3Helix, Inc. have entered a distribution agreement to expand global access to 3Helix, Inc.'s 𝗖𝗼𝗹𝗹𝗮𝗴𝗲𝗻 𝗛𝘆𝗯𝗿𝗶𝗱𝗶𝘇𝗶𝗻𝗴 𝗣𝗲𝗽𝘁𝗶𝗱𝗲𝘀 (𝗖𝗛𝗣𝘀) technology 🔬🧪

ilexlife.com/blogs/news/3...

#collagen #extracellularmatrix #regenerativemedicine #fibrosis #cellculture #tissueengineering

JHC was at the ASMB Biennial Meeting in Baltimore!

Check out the ASMB abstracts that are published in the Nov/Dec 2025 issue of JHC!

🔗 journals.sagepub.com/doi/abs/10.1...

@amsocmatbio.bsky.social #histochemistry #cellbiology #extracellularmatrix

Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in colorectal cancer - Molecular Biomedicine Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with its heterogeneous molecular profiles complicating prognosis prediction. Multi-omics profiling of clinical CR...

#Research
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in #ColorectalCancer doi.org/10.1186/s435...

#Myofibroblasts #ExtracellularMatrix #TNS1 #FERMT2

JHC was at the ASMB Biennial Meeting in Baltimore!

Check out the ASMB abstracts that are published in the Nov/Dec 2025 issue of JHC!

🔗 journals.sagepub.com/doi/abs/10.1...

@amsocmatbio.bsky.social #histochemistry #cellbiology #extracellularmatrix

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation Summary: The key adhesion protein focal adhesion kinase (FAK) transduces adhesion signals to enhance glycolysis and oxidative phosphorylation in a glioblastoma stem-cell model, highlighting a…

Roza Masalmeh, @margaretframe.bsky.social & co uncover a FAK–ROCK-driven mechanism that links #ExtracellularMatrix mechanical cues to the rewiring of energy #metabolism, affecting mitochondrial function and malignant behaviour.
#mitochondria #cancer

Read doi.org/10.1242/dmm....

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...

Mechanoenhancers regulate how cells translate mechanical cues into gene activity and functional behaviors ➡️ www.science.org/doi/10.1126/...
#enhancer #generegulation #mechanotransduction #extracellularmatrix

JHC was at the ASMB Biennial Meeting in Baltimore!

Check out the ASMB abstracts that are published in the Nov/Dec 2025 issue of JHC!

🔗 journals.sagepub.com/doi/abs/10.1...

@amsocmatbio.bsky.social #histochemistry #cellbiology #extracellularmatrix

JHC was at the ASMB Biennial Meeting in Baltimore!

Check out the ASMB abstracts that are published in the Nov/Dec 2025 issue of JHC!

🔗 journals.sagepub.com/doi/abs/10.1...

@amsocmatbio.bsky.social #histochemistry #cellbiology #extracellularmatrix

This review highlights how #MesenchymalStemCells exert therapeutic effects through #ParacrineSignaling—releasing #GrowthFactors, #cytokines, #chemokines, #ExtracellularMatrix components, & extracellular vesicles shaped by the #microenvironment.

#OpenAccess: doi.org/10.1016/j.ge...

TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...

Please check out our latest publication showing that activated #muscle stem cells depend on a niche-restricted, autoregulatory #fibronectin splice variant that is strongly affected by #aging.

🔗 www.nature.com/articles/s41...

#StemCells #SkeletalMuscle #MuSCs #ExtracellularMatrix #Splicing

Read the latest in JHC: "Immunohistochemical Assessment of Cardiac Macrophages in the Aged Fischer 344 Rat."

Click to read: bit.ly/4qvjnl8

#immunohistochemistry #extracellularmatrix #macrophages

New in JHC: "Stromal Cells, Extracellular Matrix Components, and Adenosine A3 Receptor in Prostate Biopsies: Association With Histological Grade, PSA Levels, and Clinical Tumor Stage."
Click to read: bit.ly/3VEmrNr

#extracellularmatrix #prostatecancer #stromalcells

Making tracks: microglia and the extracellular matrix - Molecular Neurodegeneration Microglia are resident immune cells of the central nervous system (CNS) and critical regulators of neural homeostasis, mediating immune surveillance, synaptic remodeling, debris clearance, and inflammatory signaling. Emerging evidence highlights the extracellular matrix (ECM) as important to microglial behavior in both physiological and pathological contexts. The CNS ECM is a dynamic and bioactive scaffold composed of three primary compartments: interstitial matrix, basement membranes at neurovascular and neuroepithelial interfaces, and perineuronal nets (PNNs). Each compartment exhibits distinct molecular architectures, ranging from fibrillar collagens and glycoproteins in basement membranes to chondroitin sulfate proteoglycans and hyaluronan-rich structures in PNNs. In this review we examine how microglia engage with and reshape the ECM to dynamically respond to disruptions in homeostasis with aging and disease. We discuss the concept of the microglial–ECM “interactome”, which may represent a molecular interface through which microglia sense, modify, and respond to their extracellular environment. This interactome enables microglia to enact fine-scale ECM remodeling during routine surveillance, as well as large-scale alterations under pathological conditions to help preserve function and motility. In aging and disease, dysregulation of the microglial-ECM interactome is characterized by aberrant mechanotransduction, elevated proteinase activity, remodeling of the ECM, and sustained pro-inflammatory cytokine release. These pathological changes compromise ECM integrity, challenge microglial activity, and contribute to progressive neurovascular and synaptic dysfunction. Deciphering the molecular mechanisms underpinning microglial–ECM interactions is essential for understanding region-specific vulnerability in neurodegeneration and may reveal new therapeutic targets for preserving ECM structure and countering CNS disorders.

'Making tracks: #microglia and the #ExtracellularMatrix'

Lauren K. Wareham & David J. Calkins #neurodegeneration

molecularneurodegeneration.biomedcentral.com/articles/10....

New in JHC: "Stromal Cells, Extracellular Matrix Components, and Adenosine A3 Receptor in Prostate Biopsies: Association With Histological Grade, PSA Levels, and Clinical Tumor Stage."
Click to read: bit.ly/3VEmrNr

#extracellularmatrix #prostatecancer #stromalcells

New in JHC: "Stromal Cells, Extracellular Matrix Components, and Adenosine A3 Receptor in Prostate Biopsies: Association With Histological Grade, PSA Levels, and Clinical Tumor Stage."

Click to read: bit.ly/3VEmrNr

#extracellularmatrix #prostatecancer #stromalcells

New in JHC: "Stromal Cells, Extracellular Matrix Components, and Adenosine A3 Receptor in Prostate Biopsies: Association With Histological Grade, PSA Levels, and Clinical Tumor Stage."

Click to read: bit.ly/3VEmrNr

#extracellularmatrix #prostatecancer #stromalcells

#LongRangeBiomechanics #ActiveNematics

Use liquid crystalline (LC, RM257) polymer to segregate mechanical/stiffness anisotropy from contact guidance of #ExtraCellularMatrix

Myotubes+ECM align with nematic director of anisotropic monodomain LC network

#SciAdv 2024
www.science.org/doi/10.1126/...

My 5 Raw Truths About Regeneration: Why Stem Cell Science Isn't Magic Uncover the 5 raw truths about stem cells and tissue repair. A 40-something professional shares personal insights on regenerative medicine and develop

Uncover the 5 raw truths about stem cells and tissue repair. A 40-something professional shares personal insights on regenerative medicine and developmental biology. #RegenerativeMedicine #StemCells #TissueRepair #DevelopmentalBiology #ExtracellularMatrix pedesinfo.blogspot.com/2025/08/my-5...

Mechanobiology of the Extracellular Matrix This Collection aims to highlight fundamental and translational advances in ECM mechanobiology.

🔔🧪 Call for Papers – #Mechanobiology of the #ExtracellularMatrix 🧬🛠️

Excited to serve as Guest Editor — together with Jacopo di Russo and Jennifer Young — of a new 𝐧𝐩𝐣 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐏𝐡𝐲𝐬𝐢𝐜𝐬 𝐚𝐧𝐝 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐬 Collection on “Mechanobiology of the ECM”.

Deadline: 14 May 2026!

www.nature.com/collections/...

Anti-isoDGR immunotherapy stabilizes Aged 🐭 #BloodBrainBarrier

#ExtraCellularMatrix Protein Deamidation
Asn-Gly-Arg/NRG➡️isoaspartate-Gly-Arg/isoDGR
⏫in #Aging

isoDGR on #EndothelialCell in vitro
👉Actin cytoskeletal alterations
👉Inflammation
👉Senescence

bioRxiv 2025
www.biorxiv.org/content/10.1...

De novo perineural nets (PNNs) develop in the SR and SLM layers of the CA1 hippocampus following pilocarpine-induced status epilepticus.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #CA1 #epileptogenesis #extracellularmatrix #hippocampus #perineuronalnets

Happened today at @gliameeting.bsky.social #GLIA2025

#ExtracellularMatrix and #Glia.

#SiegertLab (ISTA, Austria) and Sabina Berretta (#harvard), and co-chaired by Dityatev (DZNE Magdeburg) and @soriafn.bsky.social (#ACHUCARRO)

#ThrowbackThursday in JHC: "DCM-Spheroid Morphs Express PADs and Citrullinated Cytoskeletal Proteins."

Click to read for FREE: bit.ly/4eqIgZ7

#citrullinatedECM #extracellularmatrix #immunofluorescence

Join us at #AGEAnnualMeeting2025 for Session 7: Extracellular Matrix on May 13, 2025, 1:30–3 PM at Tikahtnu Ballroom.
Speakers: Andrew Dillin, Subhasri Biswas, Katarzyna Cieslik, Jessica Proulx, and Elizabeth Harper.
bit.ly/4cJx8Gd
#ExtracellularMatrix #AgingResearch #MitochondrialAging

Tomorrow!!! Hear Karan's success story with 3DBioFibR and get inspired!!! #ECM #MatrixIsEverywhere #ExtracellularMatrix #startup #scicom
Register here: forms.gle/m58YVKTATq8y...

Profibrotic role of the SOX9–MMP10–ECM biosynthesis axis in the tracheal fibrosis after injury and repair

This study demonstrates the profibrotic activity of #SOX9 in fibroblast activation, cell proliferation, #ExtracellularMatrix (ECM) deposition, and cell #apoptosis in rat tracheal fibroblast (RTF) cells through activation of Wnt/β-catenin signaling. #medsky

#OpenAccess: buff.ly/yyIx9P2

#ThrowbackThursday Special Topic: Endothelial Cell and Pericyte Homeostasis and Pathogenesis article in JHC: "Diabetes as a Pancreatic Microvascular Disease—A Pericytic Perspective."

Click to read for FREE: bit.ly/3TVF13C

#diabetes #extracellularmatrix #ecmatrix

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

➡️ buff.ly/iUdoq6J

🖊️ @StigOveBoe @sngrelli

#ZNF469 #ExtracellularMatrix