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Symbiotic relationships BMC Biology is calling for submissions to our Collection on Symbiotic relationships. Symbiotic relationships are fundamental interactions between different ...

📢 Call for papers - Symbiotic relationships 📢
#BMCBiology

Guest Editors:
@yjluo.bsky.social
@schwarzergnoto.bsky.social
Thomas Bosch Dr rer nat, Kiel University
Anil Kumar PhD, Chandigarh University
Michael Sinvula Lukubwe BA, MSc, University of Namibia

link.springer.com/collections/...

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📢 Call for papers - Epigenetic therapies 📢
#BMCBiology
Submission Deadline: 23 Dec 2026

Guest Editors:
Rene Cortese PhD, University of Kansas Medical Center
Bozena Smolkova PhD, Biomedical Research Center of the Slovak Academy of Sciences

link.springer.com/collections/...

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Nictation behavior in nematodes - BMC Biology Nictation is a dispersal behavior in nematodes, aiding movement and host-finding under stress. This review explores its diversity, genetic and neuronal basis, regulation, and ecological relevance. Nic...

C. elegans. They wiggle forward. They wiggle backwards. And occasionally they...stand up and wiggle?

Learn more about this hitchhiking-like behavior, nictation, in not just C. elegans, but many species of nematodes in this #BMcBiology Review

link.springer.com/article/10.1... #WormSky #AcademicSky

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Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates - BMC Biology Background Drosophila melanogaster has been a valuable model for dissecting the molecular architecture of innate immunity. However, the family Drosophilidae encompasses over 4000 species, spanning dee...

Move over Drosophila melanogaster

@pankajd.bsky.social & @darrenobbard.bsky.social examine 3 non-model drosophilid species, H. cameraria, H. confusa, & S. deflexa, and show striking lineage-specific differences in immune gene repertoire & expression

link.springer.com/article/10.1...
#BMCBiology

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Cellular uptake of extracellular dsRNA is tissue-dependent in insects - BMC Biology Background RNA interference (RNAi), a naturally occurring gene silencing mechanism found in almost all eukaryotic organisms, has proven to be an adaptable and powerful tool in therapeutics, bioenginee...

RNAi is a naturally occurring gene silencing mechanism but the differential responses to RNAi is a limiting factor.

This multi-omics study in #BMCBiology characterized dsRNA uptake mechanisms across tissues in the migratory locust, Locusta migratoria (Orthoptera).
link.springer.com/article/10.1...

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FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models - BMC Biology Background Protein aggregation is indicative of the loss of proteostasis associated with neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Pr...

From the lab of Martin Duennwald, new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

link.springer.com/article/10.1...
#BMCBiology #Yeast #Aging #Neurodegeneration

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Metabolomic and microbiome integration of Han-Tibetan and plain-plateau populations - BMC Biology Background Recent studies focus on the genetic and physiological characteristics of the plains Han, plateau Han, and Tibetan populations. However, systematic studies on the differences in metabolic an...

How does your microbiome and metabolism help you adapt to different environments such as higher altitudes?

Li et al. studied this in humans in their recent paper in #BMCBiology
link.springer.com/article/10.1...
#MicroSky 🦠 🧪

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Synonymous codon usage defines functional gene families - BMC Biology Background The degeneracy of the genetic code is increasingly recognized for roles in regulating translation rate, protein folding, and cell response. However, the functional genomics of codon usage p...

Codons might be synonymous codons but they are not equal.

In this study, authors test the hypothesis that functional gene families have distinct values of codon bias in the S. cerevisiae genome by modeling isoacceptor codon distributions.
link.springer.com/article/10.1...
#BMCBiology

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Horizontal transfer of post-translational modifiers brings evolutionary opportunity and challenges to a conserved translation factor - BMC Biology Background Horizontal gene transfer (HGT) is a major driver of microbial evolution, yet the influence of host cellular context on the integration and functionality of transferred genes remains underex...

Brewer et al. investigated how host background impacts the horizontal acquisition of post-translational modifications in E. coli.

They found that different EF-P variants are impacted in different ways by off-target rhamnosylation.

link.springer.com/article/10.1...
#BMCBiology #MicroSky 🦠🧬

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Influence of developmental diet on adult energy reserves in Drosophila - BMC Biology Background Nutrition during early life often has lasting consequences for adult physiology. However, it remains unclear how developmental diet shapes both the initial energetic state and subsequent ch...

How does what you eat in early life shape your energy stores later as an adult?

That's TBD in humans. But Peter Klepsatel & co showed there is an effect in fruit flies and it is modulated by sex and reproductive status 🪰

link.springer.com/article/10.1...
#BMCBiology

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Systems genetics of lifespan and senescence in Drosophila melanogaster - BMC Biology Background As populations age, the number of people with age-related chronic diseases increases, causing significant social, economic and health problems. Natural variation in lifespan depends on mult...

Can we learn about aging from flies? 👵🪰

Trudy Mackay & co performed whole genome sequencing on young and old flies and found many human orthologs associated with senescence and lifespan, indicating translational potential to human populations.

link.springer.com/article/10.1...
#BMCBiology

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Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition - BMC Biology Background Several intercellular signalling pathways (including wingless (Wnt), hedgehog (Hh), and bone morphogenetic protein (BMP)) are used repeatedly in animals throughout development and evolution...

Check out this study from @ntorresag.bsky.social & co in #BMCBiology that shows how an increase in isoform diversity of the transcription factors in major signalling pathways have a disproportionate role in the evolutionary origin & diversification of vertebrates

link.springer.com/article/10.1... 🧪

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The key role of cheaters in the persistence of cooperation - BMC Biology Background Evolution of cooperation is a major, extensively studied problem in evolutionary biology. Cooperation is beneficial for a population as a whole but costly for the bearers of social traits s...

I tell my students cheating is bad but what about when it comes to evolution?

Read this article from Sansar Babajanyan, Yuri Wolf, Eugene Koonin & Nash Rochman in #BMCBiology to find out 🔍

The key role of cheaters in the persistence of cooperation
link.springer.com/article/10.1...
#AcademicSky 🧪

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Immune cell-resolved transcriptomics provides insights into the basis for variations of fish genetic resistance to viral disease - BMC Biology Background The genetic basis of host resistance to viral infections is generally shaped by complex interactions between host genetic variations affecting antiviral immunity and the rapid evolutionary ...

Immune cell-resolved transcriptomics provides insights into the basis for variations of fish genetic resistance to viral disease

link.springer.com/article/10.1...
#BMCBiology #Ichthyology 🐟

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Axolotls retain fertility throughout lifespan - BMC Biology Background Salamanders such as axolotls exhibit exceptional regenerative abilities and longevity. While many ectothermic species reproduce into old age, axolotls have been proposed to experience post-...

The Yun Lab shows that Axolotls exhibit limited reproductive senescence and retain fertility throughout lifespan

link.springer.com/article/10.1...
#BMCBiology

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Agathis vs. Hymenaea—trapping biases to interpret arthropod assemblages in ambers - BMC Biology Background The genera Agathis (Coniferales: Araucariaceae) and Hymenaea (Fabales: Fabaceae) contain resin-producing tree species that are crucial for actuotaphonomic studies. While certain Cretaceous ...

Hymenaea resin traps EVERYTHING, while Agathis resin says ‘no thanks’ to bugs.

Me too. Agathis, me too.

link.springer.com/article/10.1... #BMCBiology #FossilFriday

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a man is holding a piece of rock that is glowing Alt: Scene from the original Jurassic Park movie zooming in on amber resin that trapped the mosquito that the dinosaur DNA was extracted from

This is an iconic scene (at least for all us "old" people).

This #BMCBiology study shows different types of resins have different biases of what they trap.

So if you're hoping to clone dinosaurs this weekend look for Hymenaea resin not Agathis #FossilFriday 🦟🦕

link.springer.com/article/10.1...

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A foul odor from the mesozoic: early evolution of scent gland defense in pentatomomorphan true bugs (Hemiptera: Heteroptera) - BMC Biology Background Insects have evolved various antipredator defenses, some of which produce copious chemicals when threatened, such as ants, beetles, butterflies, moths, stick insects, and true bugs. The tru...

Check out the #BMCBiology article to learn about the OG stink bugs and this smelly evolutionary tradition #FossilFriday
link.springer.com/article/10.1...

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Insights into the molecular determinants of host specificity in Pseudomonas aeruginosa-infecting phages: a structural and functional analysis of tail fibre proteins - BMC Biology Background Bacteriophages and bacteria frequently occupy the same ecological niches, driving complex and dynamic host–virus interactions. In Pseudomonas aeruginosa, phages from the Migulavirinae subfa...

When we think about host-pathogen interactions we often forget about the fact, bacteria can be the hosts too! This study looks into the molecular basis of host specificity in Litunavirus and Luzseptimavirus phages
link.springer.com/article/10.1...
#BMCBiology #MicroSky #ViroSky🦠 🧪

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Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens - BMC Biology Background Pseudomonas fluorescens is a Gram-negative bacterium with a remarkable metabolic and physiological versatility that enables it to adapt and colonize diverse ecological niches, including the...

Usually when we think serotonin, we think about brains 🧠But this study in #BMCBiology shows how serotonin affects the bacteria, P. fluorescens.

Why is this important? Your gut! E.g. Celiac disease is a serotonin-rich environment
link.springer.com/article/10.1...
#MicroSky 🦠 🧪

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Butterfly brains change in morphology and in gene splicing patterns after brief pheromone exposure - BMC Biology How insect brains differ between the sexes and respond to sex-specific pheromones is still not well understood. Here we briefly exposed female Bicyclus anynana butterflies to wild type and modified ma...

This study by Dion et al. showed extensive sexual dimorphism in gene splicing in male and female butterfly brains after pheromone exposure 🦋🧠
link.springer.com/article/10.1...
#BMCBiology

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Parental fasting effects on offspring immune gene expression, epigenetic patterns, and gut microbiota in a species with male pregnancy (Syngnathus typhle) - BMC Biology Background Intermittent fasting is widely promoted for its potential to improve health and extend lifespan, yet these benefits may come at a reproductive cost, potentially reducing parental fitness an...

From the lab of @oliviaroth.bsky.social, an examination of the effects of parental intermittent fasting on offspring in Syngnathus typhle (a model for male pregnancy)

link.springer.com/article/10.1...
#BMCBiology

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#FossilFriday #BMCBiology

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#FossilFriday #BMCBiology

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Cancer metabolism BMC Biology is calling for submissions to our Collection on Cancer metabolism. Cancer metabolism is a developing field that explores the biochemical and ...

📢 Call for papers - Cancer metabolism 📢
Submission Deadline: 30 October 2026
#BMCBiology

Guest Editors:
Eyal Gottlieb, @mdanderson.bsky.social
Zeping Hu, @tsinghuauniversity.bsky.social

Details: link.springer.com/collections/...
#MedSky #CancerSky

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Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti - BMC Biology Background Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signali...

Y Kato, A Oi, N Dohmae, F Obata & C Sakuma systematically profiled #aminoacids in the #mosquito body, ovaries and excreta over time after blood feeding and found distinct temporal dynamics across amino acids, balancing demands of egg maturation and survival.
In #BMCBiology
doi.org/10.1186/s129...

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Calling for your papers for the upcoming #BMCBiology collection “Regeneration: Wound Healing, Reprogramming, and Tissue Engineering.”
Excited to serve as Guest Editor and can’t wait to read your submissions!
🔗 www.biomedcentral.com/collections/...

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Again a good experience with the process at #BMCBiology

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Fig. 3 of linked article
Figure description:
Hypothesis of reduction of Phoridae radial veins. a Proximal wing, long fork of RP fork ①. b Recent wing, short fork of RP vein ②. c Wing with an important reduction of venation, lost fork of RP vein ③, and distal reduction of RA vein ④. d Zoom of possibility of reduction of RP1+2, lost of RP1+2 vein either distally or proximally Ⓐ, or by the fusion of RP1+2 and RP3+4 veins Ⓑ

Fig. 3 of linked article Figure description: Hypothesis of reduction of Phoridae radial veins. a Proximal wing, long fork of RP fork ①. b Recent wing, short fork of RP vein ②. c Wing with an important reduction of venation, lost fork of RP vein ③, and distal reduction of RA vein ④. d Zoom of possibility of reduction of RP1+2, lost of RP1+2 vein either distally or proximally Ⓐ, or by the fusion of RP1+2 and RP3+4 veins Ⓑ

Veins are crucial for phylogenetic and taxonomy studies. This study examined Cretaceous fossils and modern humpbacked flies (scuttle flies) to propose new wing models for rapid ID of Phoridae wing veins based on their degree of reduction. #FossilFriday #PaleoSky #BMCBiology 🧪 🪰
buff.ly/e5VLx00

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Fig 1 of the article linked. Figure description:
A Independent evolution of gut-sampling lymphoid tissue across vertebrates, giving rise to unique organs such as the pancreas of Aselli in shrews and the sacculus rotundus in lagomorphs. B Both the pancreas of Aselli and cloacal bursa are prominent early in life, suggesting an important role in early immunity. However, unlike the cloacal bursa, the pancreas of Aselli persists into adulthood, emphasizing function beyond early-life immunity. C Shrews operate near their maximum energy allowance due to their exceptionally high basal metabolic rates. As they approach reproductive age, their energy demands may exceed sustainable levels, creating trade-offs between physiological functions. The pancreas of Aselli may represent an adaptive strategy that minimizes energetic cost of immune function during reproduction by serving as an early-life investment in immunity

Fig 1 of the article linked. Figure description: A Independent evolution of gut-sampling lymphoid tissue across vertebrates, giving rise to unique organs such as the pancreas of Aselli in shrews and the sacculus rotundus in lagomorphs. B Both the pancreas of Aselli and cloacal bursa are prominent early in life, suggesting an important role in early immunity. However, unlike the cloacal bursa, the pancreas of Aselli persists into adulthood, emphasizing function beyond early-life immunity. C Shrews operate near their maximum energy allowance due to their exceptionally high basal metabolic rates. As they approach reproductive age, their energy demands may exceed sustainable levels, creating trade-offs between physiological functions. The pancreas of Aselli may represent an adaptive strategy that minimizes energetic cost of immune function during reproduction by serving as an early-life investment in immunity

From the @labdavalos.bsky.social lab
Gene expression reveals the pancreas of Aselli as a critical organ for plasma cell differentiation in the Eurasian common shrew
buff.ly/qaNBmwF
#BMCBiology #EvoSky #ImmunoSky 🧪

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