Use of #baloxavir as adjunctive #antiviral #therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with #influenza

Use of #baloxavir as adjunctive #antiviral #therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with #influenza, etidiohnew.blogspot.com/2026/03/use-...

Nature Comms: Baloxavir outperforms oseltamivir, favipiravir, and amantadine in treating lethal influenza A(H5N1) HA clade 2.3.4.4b infection in mice CDC Influenza Antiviral Medications:  Summary for Clinicians - Jan 2026 #19,062 During any novel influenza pandemic - even one as long ant...

Which drug should countries be stockpiling in case of an #H5N1 pandemic? Maybe #baloxavir? afludiary.blogspot.com/2026/02/natu... #birdflu

#Baloxavir outperforms #oseltamivir, #favipiravir, and #amantadine in treating lethal #influenza #H5N1 HA clade 2.3.4.4b #infection in #mice

#Baloxavir outperforms #oseltamivir, #favipiravir, and #amantadine in treating lethal #influenza #H5N1 HA clade 2.3.4.4b #infection in #mice, etidiohnew.blogspot.com/2026/02/balo...

Impaired #host shutoff is a fitness cost associated with #baloxavir marboxil #resistance #mutations in #influenza A virus PA/PA-X nuclease domain

Impaired #host shutoff is a fitness cost associated with #baloxavir marboxil #resistance #mutations in #influenza A virus PA/PA-X nuclease domain, etidiohnew.blogspot.com/2026/02/impa...

Baloxavir Monotherapy Superior to Oseltamivir for the Treatment of H5N1 Influenza in Ferrets Neuraminidase inhibitors (NAIs) and cap-dependent endonuclease inhibitors (CENIs) represent two classes of antiviral drugs recommended for early treatment of patients with seasonal influenza A virus (IAV) infections. However, only limited human data, particularly on combination antiviral treatment, are available to inform optimal dosing regimens against novel IAVs, including highly pathogenic avian influenza A(H5N1) virus, associated with severe disease. Clade 2.3.4.4b A(H5N1) viruses have caused outbreaks in avian and mammalian species worldwide, highlighting the need to assess antiviral drug efficacy against these strains. We challenged ferrets with a D1.1 genotype A(H5N1) virus and treated infected animals with the NAI oseltamivir phosphate (OST) and the CENI baloxavir acid (BXA), alone or in combination, with treatment onset commencing pre- or post-symptom onset (24- or 48-hours post-inoculation (p.i.), respectively).   When administered pre- or post-illness onset, BXA, but not OST, monotherapy provided significant reduction of clinical signs and significantly decreased infectious viral levels (in both respiratory and extrapulmonary specimens) compared with mock-treated animals. Combination OST/BXA treatment, when administered pre- or post-symptom onset, resulted in significant improvements in both metrics versus OST monotherapy. These data support continued investigation of antiviral treatment modalities that include both NAI and CENI for patients with mild and severe A(H5N1) disease. Combination treatment with two antiviral drugs (oseltamivir and baloxavir) effectively limits clade 2.3.4.4b A(H5N1) influenza virus replication and disease severity in ferrets.   Published January 26, 2026: https://doi.org/10.1038/s42003-026-09607-w   

The findings highlight the better therapeutic profile of BXA as compared to oseltamivir for the treatment of avian influenza in a small animal model. #H5N1 #baloxavir

#Oseltamivir and #baloxavir monotherapy and combination #therapy efficacy against clade 2.3.4.4b #H5N1 #influenza virus infection in #ferrets

#Oseltamivir and #baloxavir monotherapy and combination #therapy efficacy against clade 2.3.4.4b #H5N1 #influenza virus infection in #ferrets, etidiohnew.blogspot.com/2026/01/osel...

Comprehensive evaluation of #therapeutic #effectiveness and #safety profiles of #baloxavir marboxil for managing #influenza virus infection in #pediatric populations: a systematic #review with pooled ...

Comprehensive evaluation of #therapeutic #effectiveness and #safety profiles of #baloxavir marboxil for managing #influenza virus infection in #pediatric populations: a systematic #review with pooled meta-analytic data, etidiohnew.blogspot.com/2026/01/comp...

Study links #baloxavir to lower hospitalization risk in flu outpatients

The antiviral medication significantly reduced hospitalizations among females and patients under 50.

www.cidrap.umn.edu/i...

Evaluation of #therapeutic effect of #baloxavir marboxil against high pathogenicity avian #influenza virus infection in #duck model

Evaluation of #therapeutic effect of #baloxavir marboxil against high pathogenicity avian #influenza virus infection in #duck model, etidiohnew.blogspot.com/2025/10/eval...

Impaired host shutoff is a #fitness cost associated with #baloxavir marboxil #resistance mutations in #influenza A virus PA/PA-X nuclease domain.

Impaired host shutoff is a #fitness cost associated with #baloxavir marboxil #resistance mutations in #influenza A virus PA/PA-X nuclease domain, etidiohnew.blogspot.com/2025/09/impa...

#Global #update on susceptibilities of #influenza viruses to #neuraminidase #inhibitors and the cap-dependent endonuclease inhibitor #baloxavir, 2020–2023

#Global #update on susceptibilities of #influenza viruses to #neuraminidase #inhibitors and the cap-dependent endonuclease inhibitor #baloxavir, 2020–2023, etidiohnew.blogspot.com/2025/06/glob...

Efficacy of #baloxavir marboxil against #bovine #H5N1 virus in mice

Efficacy of #baloxavir marboxil against #bovine #H5N1 virus in mice, etidiohnew.blogspot.com/2025/06/effi...

Efficacy of Baloxavir Marboxil Against Bovine H5N1 Virus in Mice - Nature Communications Since the first detection of highly pathogenic avian influenza (HPAI) H5N1 (clade 2.3.4.4b) in U.S. dairy cattle in early 2024, the virus has spread rapidly, posing a major public health concern as the number of human cases continues to rise. Although human-to-human transmission has not been confirmed, experimental data suggest that the bovine H5N1 virus can transmit via respiratory droplets in ferrets, highlighting its pandemic potential. With no vaccines currently available, antiviral drugs remain the only treatment option. Here, we investigate the efficacy of the polymerase inhibitor baloxavir marboxil (BXM) against this virus in mice.   We find that early treatment post-infection is effective, but delayed treatment significantly reduces BXM efficacy and increases the risk of BXM resistance, underscoring the importance of timely BXM administration for effective treatment. This study shows that early treatment with baloxavir marboxil is effective against the bovine H5N1 influenza virus, but delayed treatment significantly reduces its effectiveness and increases the risk of emergence of resistant viruses.   Published in Nat. Comm (June 20, 2025): https://doi.org/10.1038/s41467-025-60791-5

The endonuclease inhibitor potently suppresses viral replication and prevents death in animals exposed to lethal doses. However, its effectiveness drops significantly when administered one or more days after infection. #H5N1 #avianinfluenza #baloxavir

#Influenza #H1N1pdm09 Virus #Resistance to #Baloxavir, #Oseltamivir and Sialic Acid Mimetics in Single and Dual #therapies: Insights from Human Airway Epithelia and Murine Models

#Influenza #H1N1pdm09 Virus #Resistance to #Baloxavir, #Oseltamivir and Sialic Acid Mimetics in Single and Dual #therapies: Insights from Human Airway Epithelia and Murine Models, etidiohnew.blogspot.com/2025/05/infl...

Efficacy of #Baloxavir #Treatment in Preventing #Transmission of #Influenza

Efficacy of #Baloxavir #Treatment in Preventing #Transmission of #Influenza, etidiohnew.blogspot.com/2025/04/effi...

to explore the potential of combining diltiazem with direct acting antiviral targeting viral polymerase such as #baloxavir and #molnupiravir. The IFN-λ-driven cellular antiviral state induced by diltiazem confers broad-spectrum antiviral activity against influenza A...

Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow’s milk Nature Microbiology - The FDA-approved antiviral baloxavir improves disease outcomes in mice compared with oseltamivir after ocular and intranasal challenge with A(H5N1)-contaminated cow milk.

#IDSky in 🐁 , the study demonstrate that @fda.gov -approved #baloxavir Tx mediates improved disease outcomes (survival & viral dissemination) over #oseltamivir after lethal intranasal & ocular challenge with A(H5N1)-contaminated cow milk.
@naturemicrobiol.bsky.social
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Existing anti-viral could be used to treat bird flu, mouse study says

💉 Existing antiviral #baloxavir appears to be effective at treating #birdflu, according to international researchers who tested the drug in infected mice