American Trypanosomiasis (#ChagasDisease) could be treated using newly developed #Benznidazole (BNZ) orally disintegrating tablets.

Check out the full study in #JPP:

🔗 doi.org/10.1093/jpp/...

#OrphanDrugs

Long-term follow-up of individuals with Chagas disease treated with posaconazole and benznidazole in a non-endemic region: the CHAGASAZOL cohort The CHAGASAZOL trial compared posaconazole and benznidazole for treating chronic Chagas Disease. Posaconazole showed poor short-term efficacy by means of qPCR compared to benznidazole, but few studies...

#Benznidazole demonstrated a 94% parasitological negativization of #Chagas disease rate compared to posaconazole, which showed 95% parasitological failure.

Cardiac progression occurred in 5.5 % of participants after 3 to 10 years.
www.clinicalmicrobiologyandinfection.com/article/S119...

#trypanosoma cruzi PCR test+
patient received #benznidazole (200 mg 2×/d for 60 d), and had complete resolution of clinical disease by the fifth week of treatment.