Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism Renalase (Rnls), annotated as an oxidase enzyme, is a GWAS gene associated with Type 1 diabetes (T1D) risk. We previously discovered that Rnls inhibit…

MacDonald et al. found that inhibition of the oxidase enzyme Renalase defends against loss of β cell mass and islet dysfunction in chronically stressed Akita mice in vivo.

#Pancsky #Betacellsky

www.sciencedirect.com/science/arti...

Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes - Diabetologia Aims/hypothesis The organisation and cellular architecture of islets of Langerhans are critical to the physiological regulation of hormone secretion but it is debated whether human islets adhere to th...

Verschueren van Rees et al. exploited advances in immunostaining, spatial biology and machine learning to undertake a detailed, systematic analysis of adult human islet architecture in health and #type1diabetes. 🧪
#Pancsky #Betacellsky

link.springer.com/article/10.1...

Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes This study addresses the limitations of intrahepatic islet transplantation in type 1 diabetes by repurposing decellularized lungs into a human iPSC-based vascularized endocrine pancreas (iVEP). Campo ...

Campo et al. bioengineered an induced pluripotent stem cell-based version, fabricating a human iPSC-based vascularized endocrine pancreas using iPSC-derived β cells and endothelial cells. 🧪
#Diabetesresearch #T1D #PancSky #BetaCellSky

tinyurl.com/rkaunnv9

To conclude the session, our PI, Laura Marroquí, presents our findings on protecting beta cells by modulating the innate immune system. 🧪
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky

Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function | The EMBO Journal imageimagePancreatic δ-cells secrete somatostatin, a paracrine factor that inhibits insulin secretion from the islet β-cells. This study shows that somatostatin is locally detected by primary cilia on...

Nilsson et al. show that islet cell primary cilia constitute an important target of somatostatin action, which endows somatostatin with the ability to regulate islet cell function beyond acute suppression of hormone release. 🧪
#PancSky #BetaCellSky #diabetes

www.embopress.org/doi/full/10....

Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations 3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.

Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky

elifesciences.org/articles/103...

Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment Adaptable human blood vessel cells enable functional engraftment of pancreatic islets under the skin to treat diabetes.

Li et al. show that human-reprogrammed vascular endothelial cells vascularize #islets, support dynamic function in microfluidic chambers, and enable subcutaneous cotransplantation to reverse hyperglycemia in diabetic mice.
#PancSky #BetaCellSky #Diabetes

www.science.org/doi/10.1126/...

Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Have a look at our latest summary of chemical biology tools and approaches for pancreatic beta-cell biology studies together with @o-andersson-lab.bsky.social at @nchembio.bsky.social.
@www.helmholtz-munich.de #Uppsalauniversity #BetaCellsky. 🧪

www.nature.com/articles/s41...

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice Intermittent fasting (IF) is generally associated with improved metabolism, but whether there are age-dependent limitations of IF needs to be explored. Matta et al. now demonstrate that while IF impro...

Interesting data on intermittent fasting and #BetacellSky! www.cell.com/cell-reports... Would be interesting if there was any Neurog3 reawakening in this model similar to previous observations from fasting that can account for the reduced islet cell mass! www.cell.com/cell-reports...

I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!

bsky.app/profile/did:...