Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy - PubMed Titer improvement has driven process intensification in mAb manufacture. However, this has come with the drawback of high cell densities and associated process related impurities such as cell debris, host cell protein (HCP), and DNA. This affects the capacity of depth filters and can lead to carryov …

🤖 Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy.
Biotechnology progress(2022)
#Biotechnology #Science

Excerpts from Superconvergence, by best-seller Jamie Metzl Select excerpts from the pages of the new book, Superconvergence, by Jamie Metzl, best-selling author of Hacking Darwin.

Sometimes spoilers are irresistable invitations:
superconvergencebook.com/quotes-from-...
#books #future #biotechnology

Rapid serum-free/suspension adaptation: Medium development using a definitive screening design for Chinese hamster ovary cells - PubMed The biopharmaceutical industry prefers to culture the mammalian cells in suspension with a serum-free media (SFM) due to improved productivity and process consistency. However, mammalian cells preferentially grow as adherent cells in a complete medium (CM) containing serum. Therefore, cells require …

🤖 Rapid serum-free/suspension adaptation: Medium development using a definitive screening design for Chinese hamster ovary cells.
Biotechnology progress(2021)
#Biotechnology #Science

Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor - PubMed The CDK4/6 inhibitor has been shown to increase recombinant protein productivity in Chinese hamster ovary (CHO) cells. Therefore, we investigated the mechanism that couples cell-cycle inhibitor (CCI) treatment with protein productivity utilizing proteomics and phosphoproteomics. We identified mTORC1 …

🧫 Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor.
Biotechnology and bioengineering(2022)
#Biotechnology #Science

Three PhD students in lab coats aim a handheld device that emits an orange flame at a campus building.

Young woman in pink sweater leans over bowls, assisting a child; pink label indicates a researcher from di Michele Lab.

Smiling researcher in a lab coat and purple gloves holding a wash bottle and a clear cup during a lab demonstration.

Person in lab coat leaning on railing inside modern atrium, with a caption identifying them as a bionanotechnology researcher.

Our 2026 Cambridge Festival Open Day wouldn't have been possible without our amazing volunteers 📸

#CamFest

🧪⚙️🌱🔋

#ChemicalEngineering #Biotechnology #CambridgeUniversity

✨ Thrilled to welcome Vera Meyer (TU Berlin) as a #PYFF9 speaker!
🧬 A leader in #fungal #genetics, #biotechnology & #molecular #microbiology.
Don’t miss her talk! 🚀
#Biotech #FungalScience
Join us in Valencia! 🇪🇸

#Valencia2026

MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle - PubMed Chinese hamster ovary (CHO) cells represent the most widely utilized host system for industrial production of high-quality recombinant protein therapeutics. Novel CHO cell line development is achieved through genetic and cellular engineering approaches, effectively addressing limitations such as clo …

🧬 MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle.
Biotechnology and bioengineering(2025)
#Biotechnology #Science

A Multi Clone Kinetic Model for characterizing Chinese hamster ovary cell line variability - PubMed This paper presents the Multi Clone Kinetic Model (MCKM), a novel generalized kinetic mechanistic model for fed-batch cultivations of diverse Chinese hamster ovary (CHO) cell lines, producing different recombinant monoclonal antibodies (mAbs). Unlike traditional kinetic models requiring multiple cul …

💻 A Multi Clone Kinetic Model for characterizing Chinese hamster ovary cell line variability.
Journal of industrial microbiology & biotechnology(2024)
#Biotechnology #Science

Protein A and CaptureSelect FcXP Affinity Resins Possess the Capability of Differentiating Hole-hole Homodimer Isoforms - PubMed Our data suggest that Protein A and CaptureSelect FcXP affinity resins both possess the capability of differentiating hole-hole homodimer isoforms and, therefore, can be used for monitoring isoform conversion under various conditions.

💊 Protein A and CaptureSelect FcXP Affinity Resins Possess the Capability of Differentiating Hole-hole Homodimer Isoforms.
Protein and peptide letters(2023)
#Biotechnology #Science

Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media - PubMed Polyamines such as putrescine (PUT), spermidine (SPD), and spermine (SPM) are amine group-containing biomolecules that regulate multiple intracellular functions such as proliferation, differentiation, and stress response in mammalian cells. Although these biomolecules can be generated intracellularl …

🦠 Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media.
Applied microbiology and biotechnology(2023)
#Biotechnology #Science

Electrochemiluminescence Loss in Photobleaching - PubMed The effects of photobleaching on electrochemiluminescence (ECL) was investigated for the first time. The plasma membrane of Chinese Hamster Ovary (CHO) cells was labeled with a [Ru(bpy)<sub>3</sub> ]<sup>2+</sup> derivative. Selected regions of the fixed cells were photobleached using the confocal m …

🌱 Electrochemiluminescence Loss in Photobleaching.
Angewandte Chemie (International ed. in English)(2021)
#Biotechnology #Science

Scale-up issues for commercial depth filters in bioprocessing - PubMed Significant increases in cell density and product titer have led to renewed interest in the application of depth filtration for initial clarification of cell culture fluid in antibody production. The performance of these depth filters will depend on the local pressure and velocity distribution withi …

💊 Scale-up issues for commercial depth filters in bioprocessing.
Biotechnology and bioengineering(2022)
#Biotechnology #Science

Driving towards digital biomanufacturing by CHO genome-scale models - PubMed Genome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analy …

🔬 Driving towards digital biomanufacturing by CHO genome-scale models.
Trends in biotechnology(2024)
#Biotechnology #Science

Design libraries, optimize sequences, and close DBTL cycles 10x faster — connecting to your ELN/LIMS, database or our platform.

#AI Agents That Accelerate Biological R&D: From antibody optimization to fermentation scale-up, Tesela AI accelerates discovery across the full spectrum of #biotechnology.
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Scalable Biotech Manufacturing Opens Up a $14 Billion Market Opportunity The global cell therapy manufacturing sector is poised for massive growth, forecasted to reach $14 billion by 2035. Insights into recent regulatory changes and industry advancements highlight emerging opportunities.

Scalable Biotech Manufacturing Opens Up a $14 Billion Market Opportunity #USA #Vancouver,_BC #biotechnology #Cell_Therapy #Avaí_Bio

Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells - PubMed With the advent of novel therapeutic proteins with complex structures, cellular bottlenecks in secretory pathways have hampered the high-yield production of difficult-to-express (DTE) proteins in CHO cells. To mitigate their limited secretory capacity, recombinant CHO (rCHO) cells were engineered to …

🦠 Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells.
Metabolic engineering(2022)
#Biotechnology #Science

Pate's Grammar School winners of the 2026 Davidson Inventors Challenge, students in uniform holding certificates and a trophy.

Congratulations to Semper Sanare, Nil Nocere from Pate's Grammar School for winning the 2026 Davidson Inventors Challenge!

Full story on our website 👇

🧪⚙️🌱🔋

#ChemicalEngineering #Biotechnology #CambridgeUniversity #DavidsonInventorsChallenge

#Tech-oligarchs want to #bio-engineer humans like computer programs, move fast and break things. A near future more #inhuman than #neo-colonialism & #slavery.

—
#China & #USA are racing ahead on #AI dev & #biotechnology while the market is overflowing with new #neurotechnology start ups & patents.

Two-Dimensional Gel Electrophoresis and 2D-DIGE - PubMed Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) continues to be one of the most versatile and widely used techniques to study the proteome of a biological system, particularly in the separation of intact proteins. A modified version of 2D-PAGE, two-dimensional difference gel electrophor …

📈 Two-Dimensional Gel Electrophoresis and 2D-DIGE.
Methods in molecular biology (Clifton, N.J.)(2023)
#Biotechnology #Science

Original post on politico.eu

Iran war threatens a global recession, Finland’s Stubb warns The U.S. president’s European golf buddy calls for extra efforts to stop regional conflicts from spiraling toward World War III. Ira...

#Airports #Americas #Artificial #Intelligence #Baltics […]

[Original post on politico.eu]

Original post on politico.eu

Iran war threatens a global recession, Finland’s Stubb warns The U.S. president’s European golf buddy calls for extra efforts to stop regional conflicts from spiraling toward World War III. Ira...

#Airports #Americas #Artificial #Intelligence #Baltics […]

[Original post on politico.eu]

Engineering death resistance in CHO cells for improved perfusion culture - PubMed The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors, this leads to the necessity of a bleed …

🧫 Engineering death resistance in CHO cells for improved perfusion culture.
mAbs(2022)
#Biotechnology #Science

Insight Molecular Diagnostics: $2B Market for GraftAssureDx Insight Molecular Diagnostics projects a $2.0B annual addressable market for GraftAssureDx (Seeking Alpha, Mar 27, 2026) and signals a rapid commercialization push.

Insight Molecular Diagnostics: $2B Market for GraftAssureDx: Insight Molecular Diagnostics projects a $2.0B annual addressable market for GraftAssureDx (Seeking Alpha, Mar 27, 2026) and… 👈 Read full analysis #MolecularDiagnostics #HealthcareInnovation #GraftAssureDx #MarketResearch #Biotechnology

ExocubeBio: An In-situ Fluidic Platform For Microbial Exposure On The International Space Station - Astrobiology Space-based platforms currently represent the most accurate means to experimentally assess the influence of the space environment on biological systems

ExocubeBio: An In-situ Fluidic Platform For Microbial Exposure On The International Space Station
astrobiology.com/2026/03/exoc... #astrobiology #microgravity #biotechnology #ISS

https://www.icgeb.org/fellowship/ There’s still time to apply for ICGEB Fellowships! ⌛ Join a global scientific community and develop your research in an international environment. 📌 Deadline: 31 March 🔗 Apply now #ICGEB #GlobalScience #Biotechnology #LifeSciences #icgebfellowships

There’s still time to apply for ICGEB Fellowships! ⌛
Join a global scientific community and develop your research in an international environment.

📌 Deadline: 31 March
🔗 Apply now: www.icgeb.org/fellowship/

#ICGEB #GlobalScience #Biotechnology #LifeSciences #icgebfellowships

N-glycosylation regulates MET processing and signaling - PubMed MET, the receptor for the hepatocyte growth factor (HGF), is strongly associated with resistance to tyrosine kinase inhibitors, key drugs that are used in the therapy of non-small cell lung cancer. MET contains 11 potential N-glycosylation sites, but the site-specific roles of these N-glycans have n …

🧬 N-glycosylation regulates MET processing and signaling.
Cancer science(2022)
#Biotechnology #Science

Evaluation of precursor MicroRNA (pre-miRNA) as a powerful tool for robust CHO production cell line platform development - PubMed Chinese hamster ovary (CHO) cells are the most widely used host for the commercial production of recombinant therapeutic proteins. The rapidly growing demand for large quantities of biologics at controllable cost-of-goods requires continuous cell engineering and process optimization of the CHO host …

📈 Evaluation of precursor MicroRNA (pre-miRNA) as a powerful tool for robust CHO production cell line platform development.
Bioprocess and biosystems engineering(2025)
#Biotechnology #Science

Averna Therapeutics Strengthens Leadership Team to Drive Growth in Gene Insertion Technology Averna Therapeutics enhances its leadership with the appointments of Robert Mabry, Ph.D., as CSO and Richard Morris as CFO, aiming for significant advancements in genomic medicine.

Averna Therapeutics Strengthens Leadership Team to Drive Growth in Gene Insertion Technology #USA #Boston #biotechnology #Averna_Therapeutics #genomic_medicines

¿Sabías que Cuba creó un sector biotecnológico único que produjo la primera vacuna del mundo contra la meningitis B y la primera vacuna terapéutica contra el cáncer de pulmón?

Defendamos a Cuba de los intentos de EE. UU. por aplastarla El gobierno de EE. UU. bajo el mandato de Trump y Rubio está intensificando el bloqueo económico que lleva décadas imponiendo a Cuba con el fin de provocar deliberadamente condiciones de hambruna y co...

El Mundo Necesita a Cuba

A pesar de todos sus defectos, Cuba demostró que, tras siglos de colonialismo y dominación imperialista, un pueblo subyugado puede tomar el control de su tierra y sus recursos y trazar su propio camino en materia de desarrollo, relaciones internacionales y valores.