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Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First‐Degree Relatives of Patients With Bipolar Disorder Introduction Prior research suggests structural brain abnormalities and cognitive difficulties in patients with bipolar disorder. Although there is some evidence that similar structural and cognitiv...

Excited to share a new paper from our collaboration with Danish Bipolar Illness Onset Study. Read more: onlinelibrary.wiley.com/doi/10.1111/... #BipolarResearch #BIOStudy #Neuroscience #Psychiatry

Fine-mapping genomic loci refines bipolar disorder risk genes | Nature Neuroscience Bipolar disorder is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 bipolar disorder risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci and prioritized 17 likely causal SNPs for bipolar disorder. We mapped these SNPs to genes and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci and results from rare variant exome sequencing in bipolar disorder. Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment, including SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, FKBP2, RASGRP1, FURIN, FES, MED24 and THRA among others in bipolar disorder. These represent promising candidates for functional experiments to understand biological mechanisms and ther

Fine-mapping 64 loci IDs 17 causal SNPs linked to bipolar disorder, refining risk genes & function. #BipolarResearch PMID:40562893, Nat Neurosci 2025, @NatureNeuro @broadinstitute https://doi.org/10.1038/s41593-025-01998-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Dr. Johnson explains how time-restricted eating may help manage bipolar symptoms. 🍽️🧠
Watch the full video by CREST.BD ➡️ youtu.be/h_ERXf7TleM
Participate in related research: calm.berkeley.edu/participate-... #BipolarResearch #MentalHealth