#Leukocyte exploring the microenvironment videoed under a #microscope
This is what immune cells do in your body every day, they explore it in search of microbes and other danger signals
#CellMigration @cellcommlab.bsky.social @focalplane.bsky.social #BskySci 🧪🔬
re-intro to #BskySci 🧪🔬
I'm a cell biologist in love with microscopy, moving cells & organelles. I lead the @cellcommlab.bsky.social, so you know what we study ;)
I'll be posting #cellfies & movies of #cells
Let's make a nice community here!
We start with a classic: actin during #CellMigration
Not sure if the 1st time was posted as a video.
So, here we go again 👇🏽
#BskySci #scicomm 🧪🔬 @cellcommlab.bsky.social @biologists.bsky.social
The movie shows a cell moving towards the right. The actin cytoskeleton is shown in orange a cell-lenght long actin fiber is observed.
OMG finally home made .gifs are allowed here !!
Let's start the party then, with a classic of #CellMigration & #cytoskeleton
#BskySci #scicomm 🧪🔬 @cellcommlab.bsky.social @biologists.bsky.social
Want to know how the microenvironment control immune cell responses?
Zahraa Alraies & co. show that confinement-induced changes in cell shape after cytoskeleton remodeling trigger #cellmigration in leukocytes
Full here @natureportfolio.bsky.social www.nature.com/articles/s41...
#BskySci #scicomm 🧪🔬
Now that we can finally enjoy .gif in @bsky.app, let's start with a classic of #CellMigration
Here a movie of collective cell migration during wound healing videoed under a microscope.
#scicomm #bskysci 🧪🔬 @pjsaez.bsky.social
The figure shows a scheme of a branched cell migrating on a hexagonal network. Different cells in a simulation are shown in the network spanning 1-4 junctions. The bottom panels show macrophages with similar shapes to those of the simulation.
#preprint for #CellMigration lovers
We expanded our recently published model but now for cell moving a more complex network and spanning several junctions.
Spoiler: immune cells explore better the network than slow moving cells.
Full: www.biorxiv.org/content/10.1...
#scicomm #bskysci 🧪🔬
Cool paper for #BioImaging !
The multimodality cell segmentation challenge: toward universal solutions
Full: www.nature.com/articles/s41... #BskySci 🧪🔬
The image composite shows a cell migrating over a line, then facing a bifurcation with 2 possible new directions the cell has 2 arms of similar lenght, then eventually one arm grows more and the cells takes that new direction and has a linear shape again.
How do #cells decide where to go @ a symmetrical junction?
In a HFSP founded project we found that @ a junction the membrane oscillates & actin #cystoskeleton accumulation define the new direction.
+ cancer cells decide much faster!
Full rdcu.be/dwj8o
Short www.hfsp.org/hfsp-news/os...
#bskysci 🧪🔬
The figure shows brain cancer cells migrating in a tissue ex vivo. This glioma cells move on top of blood vessels that presents branches. The picture also shows cells migrating in vitro over micropatterns that mimic the same situation.
For #CellMigration lovers
How do cells decide when facing a symmetric junction?
The membrane oscillates exploring both directions until one arm wins.
TLDR: this depends on the actin cytoskeleton & cancer cells decide faster than healthy cells #scicomm #bskysci 🧪🔬
Full www.nature.com/articles/s41...
The scheme shows a migrating cell and t he dry friction as the explanation of its motility
#hotfromthepress
Super cool data showing that #CellMigration of pericytes follows a dry friction model.
One of the most interesting cells I have recently worked with.
Sagnimorte et al full: www.biorxiv.org/content/10.1...
#scicomm @cellcommlab.bsky.social #bskysci 🧪🔬
