Pleased to get this project funded (second attempt!) by the @fwf-at.bsky.social - looking forward to collaborating with a Swiss partner on #Caenorhabditis mutants affecting Golgi trafficking!
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In the December issue of #G3journal, Rockman et al. investigated the utility of obligately outcrossing #Caenorhabditis #nematodes as models for inbreeding depression, showing it is universal but highly variable among species and populations. buff.ly/BDIPbcZ
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Cel-gon-14 and Cel-ivph-3 mutants exhibit similar defects in gonad development and fertility, and are phenotypically distinct from Cbr-gon-14 and Cbr-ivph-3 mutants. (A-D) Gonad arm outgrowth is defective in Cel-gon-14 and Cel-ivph-3 mutants. (A) In wild-type hermaphrodites, two gonad arms develop from the gonad primordium in the animal midbody. In L4 larvae, the arms have developed toward the animal ends, completed a U-turn, and migrated back toward the midbody along the dorsal side of the body cavity. Asterisk indicates the position of the developing vulva opening, and a single gonad arm (posterior) is shown. (B) Cel-gon-14 mutants derived from heterozygous mothers exhibit defects in distal tip cell (DTC) differentiation and subsequent outgrowth of the gonad arms (Siegfried et al., 2004), and the gonad cells fail to migrate and frequently form a single mass of cells in the center of the animal. (C) While the gonads of Cel-ivph-3 mutants derived from heterozygous mothers are generally normal in morphology (not shown), Cel-ivph-3 mutant offspring produced by mutant mothers (m-z-) likewise exhibit gonad arm defects.
Nikita Jhaveri & co identify genetic & genomic hallmarks of the taxonomically restricted genes gon-14 and ivph-3 in #Caenorhabditis, highlighting changes that correlate when a new gene integrates into important biological processes. doi.org/10.1242/bio....
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The November issue of #G3journal highlights a #nematode model for the fitness of inbred population, showing high variability and strain-specific effects in fitness depression, where #Caenorhabditis becei had modest inbreeding depression compared to #Celegans. buff.ly/gyUWDUG
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Much of my working time yesterday was spent „chunking“ worms.
First managing to pour 39 plates from 1L NGM-agar (on Wednesday), plating a bit of E. coli OP50 (on Thursday) and finding worms on old plates, cutting the relevant pieces of agar out & transferring to a new plate (Friday).
#Caenorhabditis
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In #G3journal, Rockman et al. investigated the utility of obligately outcrossing #Caenorhabditis #nematodes as models for inbreeding depression, showing it is universal but highly variable among species and populations. buff.ly/0yeIi24
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The latest study in #G3journal shows five newly discovered and characterized #Caenorhabditis species from Indonesia. Learn more about how these closely related species are good genetics models for studies of incompatibilities arising during speciation. buff.ly/oxRFQNo
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Using #Caenorhabditis genes to reengineer insect cells to better mimic nematode glycosylation
academic.oup.com/glycob/advan...
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Intestinal #bacterium allows #microbiome-mediated protection against #pathogens ...
| #microbes | #bacteria | #Caenorhabditis | #nematode | #Pseudomonas | #sphingolipids | Via @sciencex.bsky.social
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New research on #Caenorhabditis elegans shows that cold survival involves transcriptional regulation through the #UPR, with #IRE-1/XBP-1 pathway activation benefiting cell adaptation to #cold stress.
With Melanie Engelfriet, Yanwu Guo, Eivind Valen, Rafal Ciosk from @biovitenskap.bsky.social
#eLife
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Caenorhabditis
An unidentified species of #Caenorhabditis from the Atacama desert in Chile is growing now in my lab :-)
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Unos pocos días más para aplicar a la beca #JAE-Intro-ICU que financia @microbiomacsic.bsky.social en nuestro grupo #microbiota #postbiotics #bioinformatics #caenorhabditis
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Marking NIA’s 50th anniversary Monica Driscoll, Gordon Lithgow & Patrick Phillips review #Caenorhabditis Intervention Testing Program. Conducting >725,000 animal assays over 891 trials CITP ID’d robust & reproducible interventions that extend lifespan. Which worked? link.springer.com/article/10.1...
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I think they’re here for the worm meeting #Celegans #Caenorhabditis
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