🧬 SCOPE: Breaking DNA's secret code! New chemical tool reveals protein-DNA interactions with mind-blowing precision. Genomic detective work just got a serious upgrade! 🔬 #Genomics #ScientificBreakthrough #CRISPRtech https://emmecola.github.io/genomics-daily

🧬 CRISPR breakthrough in cattle breeding! 50% gene editing efficiency unlocks new agricultural frontiers. Precision genomics FTW! 🐄 #GenomicInnovation #CRISPRtech #AgBiotech https://emmecola.github.io/genomics-daily

🧬 Prime editing game-changer! 60x fewer DNA errors = precision genome editing breakthrough. Sci-fi level accuracy for genetic research 🔬 #GenomicMedicine #CRISPRtech #GeneEditing https://emmecola.github.io/genomics-daily

CRISPR-Cas13d-mediated targeting of a context-specific essential gene enables selective elimination of uveal melanoma
Lawanprasert, A., Ma, Y. et al.
Paper
Details
#CRISPRTech #CancerResearch #UvealMelanomaTreatment

Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection | Nature Communications The CRISPR-based detection methods have been widely applied, yet they remain limited by the non-universal nature of one-pot diagnostic approaches. Here, we report a universal one-pot fluorescent method for the detection of epidemic pathogens, delivering results within 15-20 min. This method uses heparin sodium to precisely tunes the cis-cleavage capability of Cas12 via interference with the Cas12a-crRNA binding process, thereby generating significant fluorescence due to the accumulation of isothermal amplification products. Additionally, this universal assay accommodates both classic and suboptimal PAMs, as well as various Cas12a subtypes such as LbCas12a, AsCas12a, and AapCas12b. Such a robust method demonstrates sensitivity and specificity exceeding 95% in the detection of monkeypox pseudovirus, influenza A virus, and SARS-CoV-2 from saliva or wastewater samples, when compared with qPCR or RT-qPCR. Moreover, the cost of heparin sodium per thousand uses is $0.01 to $0.04 only. Collect

Breakthrough! CRISPR-based method detects pathogens in 15-20 mins using heparin for tunable Cas12 activity in a universal one-pot format. #CRISPRTech PMID:39885211, Nat Commun 2025, @NatureComms @OTSociety https://doi.org/10.1038/s41467-025-56516-3 #Medsky 🧪

Researchers use CRISPR gene-editing to create 'DNA dominos' in living cells, mimicking blockchain's append-only structure. This biological blockchain could enable new forms of data storage and computation. 🧫🔢 #CRISPRTech #BiologicalComputing